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Structure-Based Drug Design : Experimental and Computational Approaches

Author: Penelope W Codding
Publisher: Dordrecht : Springer Netherlands, 1998.
Series: NATO ASI series., Series E,, Applied sciences ;, 352.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Structure-Based Drug Design brings together scientists working on different aspects of the subject, demonstrating the necessary collaboration and interdisciplinary approach to this complex area. The focus is on X-ray crystallographic and computational approaches. The general aspects of these approaches are introduced in the first six articles. The remaining articles provide examples of the application of X-ray  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Penelope W Codding
ISBN: 9789401590280 9401590281
OCLC Number: 851386620
Description: 1 online resource (vii, 289 pages).
Contents: Steroid Hormone Structure, Receptor Binding and Activity: Empirical Drug Design --
The Cambridge Structural Database System: Conformational Analysis from Crystallographic Data --
SAR, Scope and Limitations of Molecular Design Approaches --
Computational Strategies for Modeling Receptor Flexibility in Studies of Receptor-Ligand Interactions --
Application of Machine Learning in Drug Design --
3D Molecular Similarity Methods: In Search of a Pharmacophore --
Collagenase and Family: Targets for Drug Design --
Drugs Targeting Influenza Virus Neuraminidase --
From Cyclohexane to FK506 --
Conformational Analysis by Molecular Dynamics --
The Use of Uncoded?-Amino Acids Residues in Drug Design --
Use of the Cambridge Structural Database to Study Non-Covalent Interactions: Towards a Knowledge Base of Intermolecular Interactions --
Immunoconjugates as Anti-Cancer Agents --
Database Searching using Protein Crystal Structures and Molecular Docking Procedures --
Recent Developments in Applying Machine Learning to Drug Design --
Structure-Based Design of Novel Heparin-like Anticoagulants --
Structure, Mechanism of Action and Inhibition of Dehydrogenase Enzymes --
In Search of Hypoglycaemic Agents for the Treatment of Non-Insulin Dependent Diabetes Mellitus --
3D Molecular Similarity Methods: Application to Modeling HIV-1 Reverse Transcriptase Inhibitor Binding --
Computational Approaches to Modeling Receptor Flexibility upon Ligand Binding: Application to Interfacially Activated Enzymes --
Exploring Drug Design Methods with Thymidylate Synthase --
Computational Tools for Structure-Based Drug Design --
Antibody-Antigen Interactions --
Lessons in Molecular Design --
Antibacterial Design Based on the Structures of Gyrase-Inhibitor Complexes --
Integrated Homology Modelling and X-ray Study of Herpes Simplex Virus I Thymidine Kinase.
Series Title: NATO ASI series., Series E,, Applied sciences ;, 352.
Other Titles: Proceedings of the NATO Advanced Study Institute on Experimental and Computational Approaches to Structure-Based Drug Design, Erice, Sicily, Italy, May 9-19, 1996
Responsibility: edited by Penelope W. Codding.

Abstract:

Proceedings of the NATO Advanced Study Institute on Experimental and Computational Approaches to Structure-Based Drug Design, Erice, Sicily, Italy, May 9-19, 1996  Read more...

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