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Structure-based drug design targeting infectious disease

Author: Erin M Duffy
Publisher: London : Henry Stewart Talks, 2008.
Series: Henry Stewart talks., Biomedical & life sciences collection., Mechanisms of ribosome function : insights into protein synthesis.
Edition/Format:   eVideo : Clipart/images/graphics : EnglishView all editions and formats
Database:WorldCat
Summary:
Audio-visual presentation: Many antibiotics inhibit the ribosome -- Intelligent engine builds perpetual pipeline -- Crystallography shows 50S is a target-of-targets -- From new X-ray crystals to new leads -- Analog(Trade Mark) -- LINKER essentials: tethering two binding features -- BOMB essentials -- MUSIC essentials: core-swapping -- QikProp: calculating drug-like properties -- Structures + Analog(Trade Mark):  Read more...
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Material Type: Clipart/images/graphics, Internet resource, Videorecording
Document Type: Internet Resource, Computer File, Visual material
All Authors / Contributors: Erin M Duffy
OCLC Number: 310381960
Notes: Title from title frames.
Animated audio-visual presentation with synchronized narration.
Description: 1 streaming video file (45 min.) : digital, mono, SWF file, sound, color.
Details: Mode of access: World Wide Web.; System requirements: Operating System: PC Windows 2000+, Mac OSX+ 3.2. Browser Compatibility: IE6+, Firefox 2+, Opera 9+, Safari 2+ 3.3. Browser settings: enable JavaScript, enable popups from the Henry Stewart Talks site. 3.4. Required Browser Plugins & Viewers: Adobe (Macromedia) Flash Player 7+, Adobe Acrobat Reader6.0+.
Contents: Many antibiotics inhibit the ribosome --
Intelligent engine builds perpetual pipeline --
Crystallography shows 50S is a target-of-targets --
From new X-ray crystals to new leads --
Analog(Trade Mark) --
LINKER essentials: tethering two binding features --
BOMB essentials --
MUSIC essentials: core-swapping --
QikProp: calculating drug-like properties --
Structures + Analog(Trade Mark): balanced compounds --
Case study: enhanced oxazolidinones --
Structural foundations --
Path to enhanced oxazolidinones --
Pi contributions represent key interactions --
Probing selectivity of sparsomycin --
Seeking a new lead --
Difference density map showing rib-X prototype --
Perfect match --
A minimal scaffold for lead optimization --
Minimal scaffold binds effectively in A-site --
Activity against H. influenzae --
H. influenzae activity with time evolution --
H. flu model delivers differentiable oxazolidinones --
Moderate in vivo activity measured --
Predictive model for rat oral bioavailability --
First pool of drug candidates --
Structures + predictive models = time-saving filters.
Series Title: Henry Stewart talks., Biomedical & life sciences collection., Mechanisms of ribosome function : insights into protein synthesis.
Other Titles: Use of computational chemistry and structures of ribosome complexes to design new antibiotics
Responsibility: Erin M. Duffy.
More information:

Abstract:

Audio-visual presentation: Many antibiotics inhibit the ribosome -- Intelligent engine builds perpetual pipeline -- Crystallography shows 50S is a target-of-targets -- From new X-ray crystals to new leads -- Analog(Trade Mark) -- LINKER essentials: tethering two binding features -- BOMB essentials -- MUSIC essentials: core-swapping -- QikProp: calculating drug-like properties -- Structures + Analog(Trade Mark): balanced compounds -- Case study: enhanced oxazolidinones -- Structural foundations -- Path to enhanced oxazolidinones -- Pi contributions represent key interactions -- Probing selectivity of sparsomycin -- Seeking a new lead -- Difference density map showing rib-X prototype -- Perfect match -- A minimal scaffold for lead optimization -- Minimal scaffold binds effectively in A-site -- Activity against H. influenzae -- H. influenzae activity with time evolution -- H. flu model delivers differentiable oxazolidinones -- Moderate in vivo activity measured -- Predictive model for rat oral bioavailability -- First pool of drug candidates -- Structures + predictive models = time-saving filters.

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