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  E-mail Message: I thought you might be interested in this item at http://www.worldcat.org/oclc/490311818 Title: SYNTHESE D'ANTAGONISTES DE PEPTIDOLEUCOTRIENES Author: BENAISSA BOUBIA; Charles Mioskowski Publisher: [S.l.] : [s.n.], 1990. OCLC:490311818

  
  

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Subjects

• CHIMIE : CHIMIE ORGANIQUE
• LEUCOTRIENE/ANALOGUE/COMPOSE AROMATIQUE/YLURE/OXYDO YLURE/ARSONIUM COMPOSE/ANTAGONISTE/EPOXYDE/COMPOSE VINYLIQUE/ANION

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SYNTHESE D'ANTAGONISTES DE PEPTIDOLEUCOTRIENES

Author:	BENAISSA BOUBIA; Charles Mioskowski
Publisher:	[S.l.] : [s.n.], 1990.
Dissertation:	Thèse Doctorat : CHIMIE : Strasbourg 1 : 1990.
Edition/Format:	Thesis/dissertation : Thesis/dissertation : French
Summary:	LES TRAVAUX DECRITS DANS CE MEMOIRE CONCERNENT LA SYNTHESE D'ANTAGONISTES DE PEPTIDOLEUCOTRIENES. TROIS SERIES D'ANALOGUES STABLES DE PEPTIDOLEUCOTRIENES ONT ETE DEVELOPPEES. CES STRUCTURES ONT ETE STABILISEES EN REMPLACANT LES DOUBLES LIAISONS 9,10 ET 11,12 PAR UN NOYAU AROMATIQUE PARA SUBSTITUE. DIFFERENTES MODIFICATIONS ONT ETE REALISEES SUR CES STRUCTURES, AU NIVEAU DE: LA PARTIE LIPIDIQUE, LA PARTIE POLAIRE, LA STEREOCHIMIE DE LA DOUBLE LIAISON STYRENIQUE, DU NOMBRE D'ATOMES DE CARBONE ENTRE LA FONCTION ACIDE CARBOXYLIQUE ET DU GROUPE HYDROXYLE. TOUS LES COMPOSES OBTENUS ONT ETE SOUMIS A UN TEST FONCTIONNEL VIS-A-VIS DU LTD4 SUR ILEON DE COBAYE ET A UN TEST DE LIAISON SUR LE RECEPTEUR DU LTD4.  Read more...
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