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Systematic evaluation of the mouse eye : anatomy, pathology, and biomethods

Author: Richard S Smith
Publisher: Boca Raton : CRC Press, ©2002.
Series: Research methods for mutant mice series.
Edition/Format:   Print book : CD for computer : Document   Computer File : EnglishView all editions and formats
Summary:
The high degree of similarity between mouse and human genomes and physiology has made mice the laboratory animals of choice in the search for models of human disease. In recent years, significant advances in our ability to examine the mouse eye and to view vascular and neural structures in vivo has led to a marked increase in interest in mouse ocular pathology and development. This book provides the first  Read more...
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Material Type: Document, Internet resource
Document Type: Book, Computer File, Internet Resource
All Authors / Contributors: Richard S Smith
ISBN: 084930864X 9780849308642
OCLC Number: 48098547
Description: 366 pages : illustrations ; 26 cm + 1 CD-ROM (4 3/4 in.).
Details: System requirements for disc: Windows: Pentium I processor; MS Windows 95, 98, ME, or NT 4.x. Macintosh: PowerPC processor; Mac OS v. 8.6 or higher. Both systems: 64 MB RAM; 24 MB free space on hard drive; 4-speed CD-ROM drive; SVGA monitor (800 x 600, 256 colors); Adobe Acrobat 5.x (included on disc).
Contents: Sect. I. Regional Anatomy and Development. Ch. 1. The Anterior Segment and Ocular Adnexae / Richard S. Smith, John P. Sundberg and Simon W. M. John. Ch. 2. The Posterior Segment and Orbit / Richard S. Smith, Simon W. M. John and Patsy M. Nishina. Ch. 3. Ocular Development / Richard S. Smith, Winston W.-Y. Kao and Simon W. M. John --
Sect. II. Issues in Mutant Mouse Evaluation. Ch. 4. Strain Background Disease Characteristics / Richard S. Smith and John P. Sundberg. Ch. 5. Selection of Controls / John P. Sundberg, Richard S. Smith and Simon W. M. John. Ch. 6. Genetic Approaches to Identifying QTL and Modifiers of Hereditary Ocular Phenotypes / Juergen Naggert and Patsy M. Nishina. Ch. 7. Mutagenesis and Genetic Screens in the Mouse / Timothy O'Brien --
Sect. III. Regional Ocular Pathology. Ch. 8. The Anterior Segment / Richard S. Smith, John P. Sundberg and Simon W. M. John. Ch. 9. Choroid, Lens, and Vitreous / Richard S. Smith. Ch. 10. Retina / Richard S. Smith, Norman L. Hawes and Bo Chang / [et al.]. Ch. 11. Optic Nerve and Orbit / Richard S. Smith, Simon W. M. John and John P. Sundberg --
Sect. IV. Biomethods. Ch. 12. Photography and Necropsy / Richard S. Smith, Norman L. Hawes and James Miller / [et al.]. Ch. 13. General and Special Histopathology / Richard S. Smith, Adriana Zabaleta and Simon W. M. John / [et al.]. A. Light Microscopy / Richard S. Smith, Adriana Zabaleta and Simon W. M. John. B. Electron Microscopy / Lesley S. Bechtold and Richard S. Smith. C. Immunohistochemistry / Sakae Ikeda, Melissa J. Relyea and John P. Sundberg. D. Northern and in Situ Hybridization / Sakae Ikeda, Chia-Yang Liu and Winston W.-Y. Kao. Ch. 14. Other Techniques / Gregory Martin, Richard S. Smith and Simon W. M. John / [et al.]. A. Cell Kinetics, Morphometrics, and Confocal Microscopy / Gregory Martin, Richard S. Smith and Olga V. Savinova. B. Intraocular Pressure Measurement in Mice: Technical Aspects / Simon W. M. John and Olga V. Savinova. C. Electrophysiological Testing of the Mouse Visual System / Steven Nusinowitz, William H. Ridder III and John R. Heckenlively. Ch. 15. Resources / Carol C. Linder.
Series Title: Research methods for mutant mice series.
Responsibility: editor-in-chief, Richard S. Smith ; co-editors, Simon W.M. John, Patsy M. Nishina, John P. Sundberg.
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Abstract:

Summarizes information on mouse eye anatomy, development, and pathology. This book describes the normal anatomy, pre- and postnatal development, regional pathology, and methodology for evaluation of  Read more...

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