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Targeted therapies in cancer

Author: Marc Lacroix
Publisher: New York : Nova Biomedical, [2014] ©2014
Series: Cancer etiology, diagnosis, and treatments.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
Since the year 2000, exciting developments in cancer therapy have occurred. For decades in the 20th century, the hallmark of medical treatment for cancer had been cytotoxic chemotherapy, with drugs targeting rapidly dividing cells, including cancer cells but also certain normal tissues. As a result, many patients experienced the ""classic"" toxicities of alopecia, gastrointestinal symptoms and/or myelosuppression.  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Targeted therapies in cancer
(OCoLC)883649715
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Marc Lacroix
ISBN: 9781633216877 163321687X
OCLC Number: 891076489
Description: 1 online resource (xi, 233 pages).
Contents: TARGETED THERAPIES IN CANCER; TARGETED THERAPIES IN CANCER; Library of Congress Cataloging-in-Publication Data; Contents; Preface; Chapter 1: Innovation in the Biopharmaceutical Pipeline; Abstract; Introduction; Drug Discovery and Development Process; Discovery and Preclinical Testing; Clinical Testing in Human Subjects; Regulatory Review and Approval; Post-Approval Research and Monitoring; References; Chapter 2: The Diversity of Targeted Cancer Drugs Recently Approved by the FDA; Abstract; Introduction; 1) Tyrosine Kinase (TK) Inhibitors (TKIs) 2) Serine/Threonine Kinase Inhibitors (STKIs)3) Monoclonal Antibodies (MAbs); 4) Decoy Vascular Endothelial Growth Factor Receptor; 5) Immunomodulatory Agents; 7) Antimetabolites; 8) Enzymes; 9) Histone Deacetylase (HDAC) Inhibitors; 10) Proteasome Inhibitors; 11) Hedgehog Pathway Inhibitor; 12) Protein Translation Inhibitor; 13) Hormone (Androgen Deprivation) Therapy; 14) Microtubule Targeting Agents; 15) Autologous Cellular Immunotherapy; 16) Radiopharmaceutical Compound; References; Chapter 3: Chronological List of Targeted Cancer Drugs Approved by the FDA; Abstract; Introduction ReferenceChaper 4: Targeted Therapies: Detailed Description; Abstract; Introduction; Rituximab; Trastuzumab; Imatinib; Alemtuzumab; Ibritumomab; Gefitinib; Tositumomab; Azacitidine; Pemetrexed; Cetuximab; Bevacizumab; Erlotinib; Nelarabine; Sorafenib; Pegaspargase; Lenalidomide; Sunitinib; Dasatinib; Panitumumab; Vorinostat; Bortezomib; Decitabine; Lapatinib; Temsirolimus; Ixabepilone; Nilotinib; Degarelix; Everolimus; Pralatrexate; Pazopanib; Ofatumumab; Romidepsin; Cabazitaxel; Sipuleucel-T; Eribulin; Denosumab; Ipilimumab; Vandetanib; Abiraterone; Vemurafenib; Brentuximab; Crizotinib Asparaginase Erwinia chrysanthemiAxitinib; Vismodegib; Pertuzumab; Carfilzomib; Ziv-aflibercept; Enzalutamide; Bosutinib; Regorafenib; Omacetaxine; Cabozantinib; Ponatinib; Pomalidomide; Ado-trastuzumab Emtansine; Radium Ra223; Trametinib; Dabrafenib; Afatinib; Obinutuzumab; Ibrutinib; Ramucirumab; Ceritinib; Chapter 5: Targeted Therapy for Chronic Lymphocytic Leukemia (CLL); Abstract; Introduction; Rituximab; Rituximab As a Single Agent; Chemoimmunotherapy with Rituximab; Alemtuzumab; Ofatumumab; Ofatumumab and Chlorambucil; Obinutuzumab; Ibrutinib; Conclusion; References Chapter 6: Targeted Therapy for HER-2-Positive Breast CancerAbstract; Introduction; Trastuzumab; Lapatinib; Approved for HER-2-Overexpressing Breast Cancer; Approved for Hormone-Positive and HER-2-Positive Advanced Breast Cancer; Pertuzumab; Ado-Trastuzumab Emtansine; Conclusion; References; Chapter 7: Targeted Therapy for Metastatic Breast Cancer: Varia; Abstract; Introduction; Ixabepilone; Eribulin; Everolimus; Conclusion; References; Chapter 8: Targeted Therapy for Chronic Myelogenous Leukemia (CML); Abstract; Introduction; Imatinib; Imatinib and Resistance; Nilotinib; Dasatinib; Bosutinib
Series Title: Cancer etiology, diagnosis, and treatments.
Responsibility: Marc Lacroix, Ph. D.

Abstract:

Since the year 2000, exciting developments in cancer therapy have occurred. For decades in the 20th century, the hallmark of medical treatment for cancer had been cytotoxic chemotherapy, with drugs targeting rapidly dividing cells, including cancer cells but also certain normal tissues. As a result, many patients experienced the ""classic"" toxicities of alopecia, gastrointestinal symptoms and/or myelosuppression. In the last years, however, clinical research has been strongly occupied with the identification of mutations and aberrations concerning molecular pathways in cancer and their altera.

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