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Ten years of progress in GW P body research

Author: Edward K L Chan; Marvin J Fritzler
Publisher: New York [u.a.] : Springer, 2013.
Series: Advances in experimental medicine and biology, 768.
Edition/Format:   Print book : EnglishView all editions and formats
Database:WorldCat
Summary:

This book investigates GW bodies, novel cytoplasmic foci known to be involved with a new gene regulation process mediated by microRNA, that leads to translational repression and mRNA degradation.  Read more...

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Genre/Form: Aufsatzsammlung
Document Type: Book
All Authors / Contributors: Edward K L Chan; Marvin J Fritzler
ISBN: 146145106X 9781461451068 9781461451075 1461451078
OCLC Number: 826601440
Description: XI, 276 S. : Ill., graph. Darst.
Contents: Preface.- The GW body Story as an Example of Autoantibodies with Significant Impacts to Molecular Cell Biology.- The Discovery of GW Bodies.- The Discovery and Analysis of P Bodies.- Autoantibodies to Argonaute 2 (Su antigen).- GW/P Bodies and Autoimmune Disease.- Function of GW182 and GW Bodies in siRNA and miRNA Pathways.- Post-Transcriptional Stimulation of Gene Expression by MicroRNAs.- Gawky (Gw) is the Drosophila Melanogaster GW182 Homologue.- The Role of GW182 Proteins in miRNA-mediated Gene Silencing.- Quantifying Argonaute Proteins in and out of GW/P-bodies: Implications in microRNA Activities.- Deadenylation and P-bodies.- Relationship of GW/P-bodies with Stress Granules.- Relationship of other Cytoplasmic Ribonucleoprotein (RNP) Bodies to GW/P Bodies.- A SNP in the Trinucleotide Repeat Region of the TNRC6A Gene Maps to a Major TNGW1 Autoepitope in Patients with Autoantibodies to GW182.- Reflections on Ten Years of History of, and Future Prospects for, GW182 and GW/P Body Research.- Index.
Series Title: Advances in experimental medicine and biology, 768.
Responsibility: Edward K. L. Chan ; Marvin J. Fritzler ed.

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