skip to content
Test No. 405: Acute Eye Irritation/Corrosion Preview this item
ClosePreview this item
Checking...

Test No. 405: Acute Eye Irritation/Corrosion

Author: Organisation for Economic Co-operation and Development.
Publisher: [Paris] : OECD Publishing, 2002.
Series: OECD Guidelines for the Testing of Chemicals, Section 4: Health Effects
Edition/Format:   eBook : Document : International government publication : EnglishView all editions and formats
Summary:
This method provides information on health hazard likely to arise from exposure to test substance (liquids, solids and aerosols) by application on the eye. This Test Guideline is intended preferably for use with albino rabbit. The test substance is applied in a single dose in the conjunctival sac of one eye of each animal. The other eye, which remains untreated, serves as a control. The initial test uses an animal;  Read more...
Rating:

(not yet rated) 0 with reviews - Be the first.

Subjects
More like this

Find a copy online

Links to this item

Find a copy in the library

&AllPage.SpinnerRetrieving; Finding libraries that hold this item...

Details

Genre/Form: Electronic books
Material Type: Document, Government publication, International government publication, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Organisation for Economic Co-operation and Development.
ISBN: 9789264070646 9264070648
OCLC Number: 702617765
Language Note: English.
Description: 1 online resource.
Series Title: OECD Guidelines for the Testing of Chemicals, Section 4: Health Effects
Responsibility: Organisation for Economic Co-operation and Development.

Abstract:

This method provides information on health hazard likely to arise from exposure to test substance (liquids, solids and aerosols) by application on the eye. This Test Guideline is intended preferably for use with albino rabbit. The test substance is applied in a single dose in the conjunctival sac of one eye of each animal. The other eye, which remains untreated, serves as a control. The initial test uses an animal; the dose level depends on the test substance nature. A confirmatory test should be made if a corrosive effect is not observed in the initial test, the irritant or negative response should be confirmed using up to two additional animals. It is recommended that it be conducted in a sequential manner in one animal at a time, rather than exposing the two additional animals simultaneously. The duration of the observation period should be sufficient to evaluate fully the magnitude and reversibility of the effects observed. The eyes should be examined at 1, 24, 48, and 72 hours after test substance application. The ocular irritation scores should be evaluated in conjunction with the nature and severity of lesions, and their reversibility or lack of reversibility. The individual scores do not represent an absolute standard for the irritant properties of a material, as other effects of the test material are also evaluated.

Reviews

User-contributed reviews
Retrieving GoodReads reviews...
Retrieving DOGObooks reviews...

Tags

Be the first.

Similar Items

Related Subjects:(1)

Confirm this request

You may have already requested this item. Please select Ok if you would like to proceed with this request anyway.

Linked Data


Primary Entity

<http://www.worldcat.org/oclc/702617765> # Test No. 405: Acute Eye Irritation/Corrosion
    a schema:CreativeWork, schema:Book, schema:MediaObject ;
    library:oclcnum "702617765" ;
    library:placeOfPublication <http://id.loc.gov/vocabulary/countries/fr> ;
    library:placeOfPublication <http://experiment.worldcat.org/entity/work/data/793866696#Place/paris> ; # Paris
    rdfs:comment "Unknown 'gen' value: igp" ;
    schema:about <http://id.worldcat.org/fast/853225> ; # Chemical tests and reagents
    schema:bookFormat schema:EBook ;
    schema:creator <http://viaf.org/viaf/136637910> ; # Organisation for Economic Co-operation and Development.
    schema:datePublished "2002" ;
    schema:description "This method provides information on health hazard likely to arise from exposure to test substance (liquids, solids and aerosols) by application on the eye. This Test Guideline is intended preferably for use with albino rabbit. The test substance is applied in a single dose in the conjunctival sac of one eye of each animal. The other eye, which remains untreated, serves as a control. The initial test uses an animal; the dose level depends on the test substance nature. A confirmatory test should be made if a corrosive effect is not observed in the initial test, the irritant or negative response should be confirmed using up to two additional animals. It is recommended that it be conducted in a sequential manner in one animal at a time, rather than exposing the two additional animals simultaneously. The duration of the observation period should be sufficient to evaluate fully the magnitude and reversibility of the effects observed. The eyes should be examined at 1, 24, 48, and 72 hours after test substance application. The ocular irritation scores should be evaluated in conjunction with the nature and severity of lesions, and their reversibility or lack of reversibility. The individual scores do not represent an absolute standard for the irritant properties of a material, as other effects of the test material are also evaluated."@en ;
    schema:exampleOfWork <http://worldcat.org/entity/work/id/793866696> ;
    schema:genre "Government publication"@en ;
    schema:genre "Electronic books"@en ;
    schema:inLanguage "en" ;
    schema:isPartOf <http://worldcat.org/issn/2074-5788> ; # OECD Guidelines for the Testing of Chemicals, Section 4: Health Effects,
    schema:name "Test No. 405: Acute Eye Irritation/Corrosion"@en ;
    schema:productID "702617765" ;
    schema:publication <http://www.worldcat.org/title/-/oclc/702617765#PublicationEvent/paris_oecd_publishing_2002> ;
    schema:publisher <http://experiment.worldcat.org/entity/work/data/793866696#Agent/oecd_publishing> ; # OECD Publishing
    schema:url <http://proxy.library.carleton.ca/login?url=http://dx.doi.org/10.1787/9789264070646-en> ;
    schema:url <http://dx.doi.org/10.1787/9789264070646-en> ;
    schema:url <https://dx.doi.org/10.1787/9789264070646-en> ;
    schema:url <http://dx.doi.org/10.1787/9789264070653-fr> ;
    schema:workExample <http://worldcat.org/isbn/9789264070646> ;
    schema:workExample <http://dx.doi.org/10.1787/9789264070646-en> ;
    wdrs:describedby <http://www.worldcat.org/title/-/oclc/702617765> ;
    .


Related Entities

<http://dx.doi.org/10.1787/9789264070646-en>
    a schema:IndividualProduct ;
    rdfs:comment "to access electronic resource" ;
    .

<http://dx.doi.org/10.1787/9789264070653-fr>
    rdfs:comment "OECD-iLibrary Books, Papers & Statistics" ;
    .

<http://experiment.worldcat.org/entity/work/data/793866696#Agent/oecd_publishing> # OECD Publishing
    a bgn:Agent ;
    schema:name "OECD Publishing" ;
    .

<http://id.worldcat.org/fast/853225> # Chemical tests and reagents
    a schema:Intangible ;
    schema:name "Chemical tests and reagents"@en ;
    .

<http://viaf.org/viaf/136637910> # Organisation for Economic Co-operation and Development.
    a schema:Organization ;
    schema:name "Organisation for Economic Co-operation and Development." ;
    .

<http://worldcat.org/isbn/9789264070646>
    a schema:ProductModel ;
    schema:isbn "9264070648" ;
    schema:isbn "9789264070646" ;
    .

<http://worldcat.org/issn/2074-5788> # OECD Guidelines for the Testing of Chemicals, Section 4: Health Effects,
    a bgn:PublicationSeries ;
    schema:hasPart <http://www.worldcat.org/oclc/702617765> ; # Test No. 405: Acute Eye Irritation/Corrosion
    schema:issn "2074-5788" ;
    schema:name "OECD Guidelines for the Testing of Chemicals, Section 4: Health Effects," ;
    .


Content-negotiable representations

Close Window

Please sign in to WorldCat 

Don't have an account? You can easily create a free account.