skip to content
Test no. 416 : two-generation reproduction toxicity Preview this item
ClosePreview this item
Checking...

Test no. 416 : two-generation reproduction toxicity

Author: Organisation for Economic Co-operation and Development.
Publisher: [Paris] : OECD Pub., 2001.
Series: OECD Guidelines for the Testing of Chemicals, Section 4: Health Effects
Edition/Format:   eBook : Document : International government publication : EnglishView all editions and formats
Summary:
This Test Guideline for two-generation reproduction testing is designed to provide general information concerning the effects of a test substance on the integrity and performance of the male and female reproductive systems, and on the growth and development of the offspring. The test substance is administered daily in graduated doses to several groups of males and females. Males and females of the Parent generation  Read more...
Rating:

(not yet rated) 0 with reviews - Be the first.

Subjects
More like this

Find a copy online

Links to this item

Find a copy in the library

&AllPage.SpinnerRetrieving; Finding libraries that hold this item...

Details

Genre/Form: Electronic books
Material Type: Document, Government publication, International government publication, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Organisation for Economic Co-operation and Development.
ISBN: 9789264070868 9264070869
OCLC Number: 704447717
Language Note: English.
Description: 1 online resource (13 pages).
Series Title: OECD Guidelines for the Testing of Chemicals, Section 4: Health Effects
Responsibility: Organisation for Economic Co-operation and Development.

Abstract:

This Test Guideline for two-generation reproduction testing is designed to provide general information concerning the effects of a test substance on the integrity and performance of the male and female reproductive systems, and on the growth and development of the offspring. The test substance is administered daily in graduated doses to several groups of males and females. Males and females of the Parent generation (5-9 weeks old) should be dosed during growth, during their mating, during the resulting pregnancies, and through the weaning of their first generation offspring. The administration of the substance is continued to first generation offspring during their growth into adulthood, mating and production of a second generation (until the weaning). The rat is the preferred species for testing. Each test and control group should contain a sufficient number of animals to yield preferably not less than 20 pregnant females at or near parturition. At least three dose levels and a concurrent control shall be used. It is recommended that the test substance be administered orally (by diet, drinking water or gavage). A limit test may be performed if no effects would be expected at a dose of 1000 mg/kg bw/d. The results of this study include: measurements (weighing, sperm parameters, oestrus cycle parameters and offspring parameters), clinical daily observations, as well as gross necropsy and histopathology. The findings of this two-generation reproduction toxicity study should be evaluated in terms of the observed effects including necropsy and microscopic findings. A properly conducted reproductive toxicity test should provide a satisfactory estimation of a no-effect level and an understanding of adverse effects on reproduction, parturition, lactation, postnatal development including growth and sexual development.

Reviews

User-contributed reviews
Retrieving GoodReads reviews...
Retrieving DOGObooks reviews...

Tags

Be the first.

Similar Items

Related Subjects:(1)

Confirm this request

You may have already requested this item. Please select Ok if you would like to proceed with this request anyway.

Linked Data


Primary Entity

<http://www.worldcat.org/oclc/704447717> # Test no. 416 : two-generation reproduction toxicity
    a schema:Book, schema:CreativeWork, schema:MediaObject ;
    library:oclcnum "704447717" ;
    library:placeOfPublication <http://experiment.worldcat.org/entity/work/data/793868198#Place/paris> ; # Paris
    library:placeOfPublication <http://id.loc.gov/vocabulary/countries/fr> ;
    rdfs:comment "Unknown 'gen' value: igp" ;
    schema:about <http://id.worldcat.org/fast/853225> ; # Chemical tests and reagents
    schema:bookFormat schema:EBook ;
    schema:creator <http://viaf.org/viaf/136637910> ; # Organisation for Economic Co-operation and Development.
    schema:datePublished "2001" ;
    schema:description "This Test Guideline for two-generation reproduction testing is designed to provide general information concerning the effects of a test substance on the integrity and performance of the male and female reproductive systems, and on the growth and development of the offspring. The test substance is administered daily in graduated doses to several groups of males and females. Males and females of the Parent generation (5-9 weeks old) should be dosed during growth, during their mating, during the resulting pregnancies, and through the weaning of their first generation offspring. The administration of the substance is continued to first generation offspring during their growth into adulthood, mating and production of a second generation (until the weaning). The rat is the preferred species for testing. Each test and control group should contain a sufficient number of animals to yield preferably not less than 20 pregnant females at or near parturition. At least three dose levels and a concurrent control shall be used. It is recommended that the test substance be administered orally (by diet, drinking water or gavage). A limit test may be performed if no effects would be expected at a dose of 1000 mg/kg bw/d. The results of this study include: measurements (weighing, sperm parameters, oestrus cycle parameters and offspring parameters), clinical daily observations, as well as gross necropsy and histopathology. The findings of this two-generation reproduction toxicity study should be evaluated in terms of the observed effects including necropsy and microscopic findings. A properly conducted reproductive toxicity test should provide a satisfactory estimation of a no-effect level and an understanding of adverse effects on reproduction, parturition, lactation, postnatal development including growth and sexual development."@en ;
    schema:exampleOfWork <http://worldcat.org/entity/work/id/793868198> ;
    schema:genre "Electronic books"@en ;
    schema:genre "Government publication"@en ;
    schema:inLanguage "en" ;
    schema:isPartOf <http://worldcat.org/issn/2074-5788> ; # OECD Guidelines for the Testing of Chemicals, Section 4: Health Effects
    schema:name "Test no. 416 : two-generation reproduction toxicity"@en ;
    schema:productID "704447717" ;
    schema:publication <http://www.worldcat.org/title/-/oclc/704447717#PublicationEvent/paris_oecd_pub_2001> ;
    schema:publisher <http://experiment.worldcat.org/entity/work/data/793868198#Agent/oecd_pub> ; # OECD Pub.
    schema:url <http://dx.doi.org/10.1787/9789264070875-fr> ;
    schema:url <http://proxy.library.carleton.ca/login?url=http://dx.doi.org/10.1787/9789264070868-en> ;
    schema:url <http://dx.doi.org/10.1787/9789264070868-en> ;
    schema:url <https://dx.doi.org/10.1787/9789264070868-en> ;
    schema:workExample <http://worldcat.org/isbn/9789264070868> ;
    schema:workExample <http://dx.doi.org/10.1787/9789264070868-en> ;
    wdrs:describedby <http://www.worldcat.org/title/-/oclc/704447717> ;
    .


Related Entities

<http://dx.doi.org/10.1787/9789264070868-en>
    a schema:IndividualProduct ;
    rdfs:comment "to access electronic resource" ;
    rdfs:comment "e-book" ;
    .

<http://dx.doi.org/10.1787/9789264070875-fr>
    rdfs:comment "OECD-iLibrary Books, Papers & Statistics" ;
    .

<http://id.worldcat.org/fast/853225> # Chemical tests and reagents
    a schema:Intangible ;
    schema:name "Chemical tests and reagents"@en ;
    .

<http://viaf.org/viaf/136637910> # Organisation for Economic Co-operation and Development.
    a schema:Organization ;
    schema:name "Organisation for Economic Co-operation and Development." ;
    .

<http://worldcat.org/isbn/9789264070868>
    a schema:ProductModel ;
    schema:isbn "9264070869" ;
    schema:isbn "9789264070868" ;
    .

<http://worldcat.org/issn/2074-5788> # OECD Guidelines for the Testing of Chemicals, Section 4: Health Effects
    a bgn:PublicationSeries ;
    schema:hasPart <http://www.worldcat.org/oclc/704447717> ; # Test no. 416 : two-generation reproduction toxicity
    schema:issn "2074-5788" ;
    schema:name "OECD Guidelines for the Testing of Chemicals, Section 4: Health Effects" ;
    schema:name "OECD Guidelines for the Testing of Chemicals, Section 4: Health Effects," ;
    .


Content-negotiable representations

Close Window

Please sign in to WorldCat 

Don't have an account? You can easily create a free account.