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Test no. 438 : isolated chicken eye test method for identifying. i), Chemicals inducing serious eye damage and. ii), Chemicals not requiring classification for eye irritation or serious eye damage Preview this item
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Test no. 438 : isolated chicken eye test method for identifying. i), Chemicals inducing serious eye damage and. ii), Chemicals not requiring classification for eye irritation or serious eye damage

Author: Organisation for Economic Co-operation and Development.
Publisher: Paris : OECD Publishing, 2013.
Series: OECD Guidelines for the Testing of Chemicals., Section 4.
Edition/Format:   eBook : Document : International government publication : EnglishView all editions and formats
Summary:
The Isolated Chicken Eye Test (ICE) Method is an in vitro test method that can be used to identify chemicals (substances or mixtures) as either 1) causing "serious eye damage" (category 1 of the Globally Harmonised System for the Classification and Labelling of chemicals (GHS)), or 2) not requiring classification for eye irritation or serious eye damage according to the GHS. The ICE uses eyes collected from chickens  Read more...
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Material Type: Document, Government publication, International government publication, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Organisation for Economic Co-operation and Development.
ISBN: 9789264203860 9264203869
OCLC Number: 856149530
Description: 1 online resource (20 pages) : color illustrations.
Series Title: OECD Guidelines for the Testing of Chemicals., Section 4.
Responsibility: Organisation for Economic Co-operation and Development.

Abstract:

The Isolated Chicken Eye Test (ICE) Method is an in vitro test method that can be used to identify chemicals (substances or mixtures) as either 1) causing "serious eye damage" (category 1 of the Globally Harmonised System for the Classification and Labelling of chemicals (GHS)), or 2) not requiring classification for eye irritation or serious eye damage according to the GHS. The ICE uses eyes collected from chickens obtained from slaughterhouses where they are killed for human consumption, thus eliminating the need for laboratory animals. The eye is enucleated and mounted in an eye holder with the cornea positioned horizontally. The test chemical and negative/positive controls are applied to the cornea. Toxic effects to the cornea are measured by a qualitative assessment of opacity, a qualitative assessment of damage to epithelium based on fluorescein retention, a quantitative measurement of increased thickness (swelling), and a qualitative evaluation of macroscopic morphological damage to the surface. The endpoints are evaluated separately to generate an ICE class for each endpoint, which are then combined to generate an Irritancy Classification for each test chemical.

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