skip to content
Test No. 475: Mammalian Bone Marrow Chromosomal Aberration Test Preview this item
ClosePreview this item
Checking...

Test No. 475: Mammalian Bone Marrow Chromosomal Aberration Test

Author: Organisation for Economic Co-operation and Development.
Publisher: Paris : OECD Publishing, 2016.
Series: OECD Guidelines for the Testing of Chemicals, Section 4.
Edition/Format:   eBook : Document : International government publication : EnglishView all editions and formats
Summary:
The mammalian in vivo chromosome aberration test is used for the detection of structural chromosome aberrations induced by test compounds in bone marrow cells of animals, usually rodents (rats, mice and Chinese hamsters). Structural chromosome aberrations may be of two types: chromosome or chromatid. Animals are exposed to the test substance (liquid or solid) by an appropriate route of exposure (usually by gavage  Read more...
Rating:

(not yet rated) 0 with reviews - Be the first.

Subjects
More like this

 

Find a copy online

Links to this item

Find a copy in the library

&AllPage.SpinnerRetrieving; Finding libraries that hold this item...

Details

Material Type: Document, Government publication, International government publication, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Organisation for Economic Co-operation and Development.
ISBN: 9789264264786 9264264787
OCLC Number: 961480799
Description: 1 online resource (18 pages).
Series Title: OECD Guidelines for the Testing of Chemicals, Section 4.
Responsibility: Organisation for Economic Co-operation and Development.

Abstract:

The mammalian in vivo chromosome aberration test is used for the detection of structural chromosome aberrations induced by test compounds in bone marrow cells of animals, usually rodents (rats, mice and Chinese hamsters). Structural chromosome aberrations may be of two types: chromosome or chromatid. Animals are exposed to the test substance (liquid or solid) by an appropriate route of exposure (usually by gavage using a stomach tube or a suitable intubation cannula, or by intraperitoneal injection) and are sacrificed at appropriate times after treatment. Prior to sacrifice, animals are treated with a metaphase-arresting agent. Chromosome preparations are then made from the bone marrow cells and stained, and metaphase cells are analysed for chromosome aberrations. Each treated and control group must include at least 5 analysable animals per sex. The limit dose is 2000 mg/kg/body weight/day for treatment up to 14 days, and 1000 mg/kg/body weight/day for treatment longer than 14 days.

Reviews

User-contributed reviews
Retrieving GoodReads reviews...
Retrieving DOGObooks reviews...

Tags

Be the first.

Similar Items

Confirm this request

You may have already requested this item. Please select Ok if you would like to proceed with this request anyway.

Linked Data


Primary Entity

<http://www.worldcat.org/oclc/961480799> # Test No. 475: Mammalian Bone Marrow Chromosomal Aberration Test
    a schema:MediaObject, schema:Book, schema:CreativeWork ;
   library:oclcnum "961480799" ;
   library:placeOfPublication <http://id.loc.gov/vocabulary/countries/fr> ;
   library:placeOfPublication <http://experiment.worldcat.org/entity/work/data/3902550527#Place/paris> ; # Paris
   rdfs:comment "Unknown 'gen' value: igp" ;
   schema:about <http://experiment.worldcat.org/entity/work/data/3902550527#Topic/ecology> ; # Ecology
   schema:about <http://experiment.worldcat.org/entity/work/data/3902550527#Topic/nature_and_nurture> ; # Nature and nurture
   schema:about <http://experiment.worldcat.org/entity/work/data/3902550527#Topic/euthenics> ; # Euthenics
   schema:about <http://experiment.worldcat.org/entity/work/data/3902550527#Topic/adaptation_biology> ; # Adaptation (Biology)
   schema:bookFormat schema:EBook ;
   schema:creator <http://experiment.worldcat.org/entity/work/data/3902550527#Organization/organisation_for_economic_co_operation_and_development> ; # Organisation for Economic Co-operation and Development.
   schema:datePublished "2016" ;
   schema:description "The mammalian in vivo chromosome aberration test is used for the detection of structural chromosome aberrations induced by test compounds in bone marrow cells of animals, usually rodents (rats, mice and Chinese hamsters). Structural chromosome aberrations may be of two types: chromosome or chromatid. Animals are exposed to the test substance (liquid or solid) by an appropriate route of exposure (usually by gavage using a stomach tube or a suitable intubation cannula, or by intraperitoneal injection) and are sacrificed at appropriate times after treatment. Prior to sacrifice, animals are treated with a metaphase-arresting agent. Chromosome preparations are then made from the bone marrow cells and stained, and metaphase cells are analysed for chromosome aberrations. Each treated and control group must include at least 5 analysable animals per sex. The limit dose is 2000 mg/kg/body weight/day for treatment up to 14 days, and 1000 mg/kg/body weight/day for treatment longer than 14 days."@en ;
   schema:exampleOfWork <http://worldcat.org/entity/work/id/3902550527> ;
   schema:genre "Government publication"@en ;
   schema:inLanguage "en" ;
   schema:isPartOf <http://experiment.worldcat.org/entity/work/data/3902550527#Series/oecd_guidelines_for_the_testing_of_chemicals_section_4> ; # OECD Guidelines for the Testing of Chemicals, Section 4.
   schema:isPartOf <http://worldcat.org/issn/2074-5788> ; # OECD Guidelines for the Testing of Chemicals, Section 4,
   schema:name "Test No. 475: Mammalian Bone Marrow Chromosomal Aberration Test"@en ;
   schema:productID "961480799" ;
   schema:publication <http://www.worldcat.org/title/-/oclc/961480799#PublicationEvent/paris_oecd_publishing_2016> ;
   schema:publisher <http://experiment.worldcat.org/entity/work/data/3902550527#Agent/oecd_publishing> ; # OECD Publishing
   schema:url <http://dx.doi.org/10.1787/9789264264786-en> ;
   schema:url <http://www.oecd-ilibrary.org/environment/test-no-475-mammalian-bone-marrow-chromosomal-aberration-test_9789264264786-en> ;
   schema:url <https://login.proxy.lib.strath.ac.uk/login?url=http://dx.doi.org/10.1787/9789264264786-en> ;
   schema:url <http://dx.doi.org/10.1787/9789264264793-fr> ;
   schema:workExample <http://worldcat.org/isbn/9789264264786> ;
   schema:workExample <http://dx.doi.org/10.1787/9789264264786-en> ;
   wdrs:describedby <http://www.worldcat.org/title/-/oclc/961480799> ;
    .


Related Entities

<http://dx.doi.org/10.1787/9789264264793-fr>
   rdfs:comment "OECD-iLibrary Books, Papers & Statistics" ;
    .

<http://experiment.worldcat.org/entity/work/data/3902550527#Agent/oecd_publishing> # OECD Publishing
    a bgn:Agent ;
   schema:name "OECD Publishing" ;
    .

<http://experiment.worldcat.org/entity/work/data/3902550527#Organization/organisation_for_economic_co_operation_and_development> # Organisation for Economic Co-operation and Development.
    a schema:Organization ;
   schema:name "Organisation for Economic Co-operation and Development." ;
    .

<http://experiment.worldcat.org/entity/work/data/3902550527#Series/oecd_guidelines_for_the_testing_of_chemicals_section_4> # OECD Guidelines for the Testing of Chemicals, Section 4.
    a bgn:PublicationSeries ;
   schema:hasPart <http://www.worldcat.org/oclc/961480799> ; # Test No. 475: Mammalian Bone Marrow Chromosomal Aberration Test
   schema:name "OECD Guidelines for the Testing of Chemicals, Section 4." ;
    .

<http://experiment.worldcat.org/entity/work/data/3902550527#Topic/adaptation_biology> # Adaptation (Biology)
    a schema:Intangible ;
   schema:name "Adaptation (Biology)"@en ;
    .

<http://worldcat.org/isbn/9789264264786>
    a schema:ProductModel ;
   schema:isbn "9264264787" ;
   schema:isbn "9789264264786" ;
    .

<http://worldcat.org/issn/2074-5788> # OECD Guidelines for the Testing of Chemicals, Section 4,
    a bgn:PublicationSeries ;
   schema:hasPart <http://www.worldcat.org/oclc/961480799> ; # Test No. 475: Mammalian Bone Marrow Chromosomal Aberration Test
   schema:issn "2074-5788" ;
   schema:name "OECD Guidelines for the Testing of Chemicals, Section 4," ;
    .


Content-negotiable representations

Close Window

Please sign in to WorldCat 

Don't have an account? You can easily create a free account.