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The function of dog models in developing gene therapy strategies for human health.
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The function of dog models in developing gene therapy strategies for human health.

Author: KL Nowend Affiliation: Department of Genetics and Biochemistry, Clemson University, SC 29634-0318, USA.; AN Starr-Moss; KE Murphy
Edition/Format: Article Article : English
Publication:Mammalian genome : official journal of the International Mammalian Genome Society, 2011 Aug; 22(7-8): 476-85
Database:From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
Other Databases: British Library SerialsECO
Summary:
The domestic dog is of great benefit to humankind, not only through companionship and working activities cultivated through domestication and selective breeding, but also as a model for biomedical research. Many single-gene traits have been well-characterized at the genomic level, and recent advances in whole-genome association studies will allow for better understanding of complex, multigenic hereditary diseases.  Read more...
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Document Type: Article
All Authors / Contributors: KL Nowend Affiliation: Department of Genetics and Biochemistry, Clemson University, SC 29634-0318, USA.; AN Starr-Moss; KE Murphy
ISSN:0938-8990
Language Note: English
Unique Identifier: 746075706
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Abstract:

The domestic dog is of great benefit to humankind, not only through companionship and working activities cultivated through domestication and selective breeding, but also as a model for biomedical research. Many single-gene traits have been well-characterized at the genomic level, and recent advances in whole-genome association studies will allow for better understanding of complex, multigenic hereditary diseases. Additionally, the dog serves as an invaluable large animal model for assessment of novel therapeutic agents. Thus, the dog has filled a crucial step in the translation of basic research to new treatment regimens for various human diseases. Four well-characterized diseases in canine models are discussed as they relate to other animal model availability, novel therapeutic approach, and extrapolation to human gene therapy trials.

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