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Therapeutic development in the absence of predictive animal models of nervous system disorders : proceedings of a workshop

Author: Lisa J Bain; Clare Stroud; Noam I Keren; Sheena M Posey Norris; National Academies of Sciences, Engineering, and Medicine (U.S.). Forum on Neuroscience and Nervous System Disorders,
Publisher: Washington, DC : The National Academies Press, [ 2017]
Edition/Format:   eBook : Document : Conference publication : EnglishView all editions and formats
Summary:
Compared with other disease areas, central nervous system (CNS) disorders have had the highest failure rate for new compounds in advanced clinical trials. Most CNS drugs fail because of efficacy, and the core issue underlying these problems is a poor understanding of disease biology. Concern about the poor productivity in neuroscience drug development has gained intensity over the past decade, amplified by a  Read more...
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Genre/Form: Electronic books
Conference papers and proceedings
Congresses
Additional Physical Format: Print version:
Therapeutic development in the absence of predictive animal models of nervous system disorders : proceedings of a workshop
Washington, D.C. : National Academies Press, [2017]
(OCoLC)992995030
Material Type: Conference publication, Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Lisa J Bain; Clare Stroud; Noam I Keren; Sheena M Posey Norris; National Academies of Sciences, Engineering, and Medicine (U.S.). Forum on Neuroscience and Nervous System Disorders,
ISBN: 0309455138 9780309455138 9780309455145 0309455146
OCLC Number: 989816022
Notes: "A report of the National Academies of Sciences, Engineering, Medicine."
Description: 1 online resource (1 PDF file (xii, 82 pages)) : illustrations.
Contents: Introduction and overview --
Drug development for nervous system disorders: overview of challenges adn potential opportunities --
Case studies: therapeutic development for Parkinson's disease and schizophrenia in the absence of predictive animal models of disease --
New modeling approaches for nervous system disorders --
Private-sector thresholds for investment in neuroscience clinical trials --
Ethical considerations --
Regulatory perspectives --
Appendix A: References --
Appendix B: Workshop agenda --
Appendix C: Registered attendees.
Responsibility: Lisa Bain, Sheena M. Posey Norris, Noam I. Keren, and Clare Stroud, rapporteurs ; Forum on Neuroscience and Nervous System Disorders, Board on Health Sciences Policy, Health and Medicine Division, the National Academies of Sciences, Engineering, Medicine.

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