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Therapeutic kinase inhibitors

Author: Ingo K Mellinghoff; Charles L Sawyers
Publisher: Heidelberg : Springer Verlag, 2012.
Series: Current topics in microbiology and immunology, v. 355.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
Cancer drug development is currently undergoing a profound shift. Drugs targeting fundamental cellular processes such DNA-replication and microtubule function, often referred to as "chemotherapy" and still the backbone of most cancer treatment regimens, are increasingly being complemented by or replaced with kinase inhibitors. This new class of drugs targets enzymes which provide growth and survival signals to  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Therapeutic kinase inhibitors.
Heidelberg: Springer Verlag, 2012
(OCoLC)773671497
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Ingo K Mellinghoff; Charles L Sawyers
ISBN: 9783642282966 3642282962 9781283865258 1283865254
OCLC Number: 821823527
Description: 1 online resource (x, 234 p.) : ill.
Contents: Setting up a Kinase Discovery and Development Project / Gideon Bollag --
Drug Efficacy Testing in Mice / William Y. Kim, Norman E. Sharpless --
Gastrointestinal Stromal Tumors / Cristina Antonescu --
EGFR Mutant Lung Cancer / Yixuan Gong, William Pao --
Targeting Oncogenic BRAF in Human Cancer / Christine A. Pratilas, Feng Xing, David B. Solit --
Beyond BRAF in Melanoma / Adil Daud, Boris C. Bastian --
JAK-Mutant Myeloproliferative Neoplasms / Ross L. Levine --
Will Kinase Inhibitors Make it as Glioblastoma Drugs? / Ingo K. Mellinghoff, Nikolaus Schultz, Paul S. Mischel --
Predictive Genomic Biomarkers / Rakesh Kumar, Rafael G. Amado --
Epigenetic Biomarkers / Timothy A. Chan, Stephen B. Baylin --
Adjuvant Trials of Targeted Agents: The Newest Battleground in the War on Cancer / Robert L. Cohen.
Series Title: Current topics in microbiology and immunology, v. 355.
Responsibility: Ingo K. Mellinghoff, Charles L. Sawyers, editors ; responsible series editor: Peter K. Vogt.

Abstract:

Drugs targeting fundamental cellular processes such DNA-replication and microtubule function, often referred to as "chemotherapy" and still the backbone of most cancer treatment regimens, are  Read more...

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