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Therapeutic peptides and proteins : formulation, processing, and delivery systems

Author: Ajay K Banga
Publisher: Lancaster, Pa. : Technomic Pub., ©1995.
Edition/Format:   Print book : EnglishView all editions and formats
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Document Type: Book
All Authors / Contributors: Ajay K Banga
ISBN: 1566763290 9781566763295
OCLC Number: 34130800
Description: xiii, 317 pages : illustrations ; 24 cm
Contents: Preface Part I: Formulation and ProcessingPharmaceutical Biotechnology: The Arrival of Recombinant ProteinsIntroduction - What is Biotechnology? - The Biotechnology Industry - Regulatory Aspects of Biotechnology-Derived Drugs - Structure-Based Drug Design - Conclusions - References Structure and Analysis of Therapeutic Peptides and ProteinsIntroduction - Amino Acids: Building Blocks of Proteins - Structure of Peptides and Proteins - Protein Conformation and Other Structural Features - Analytical Methods - Conclusions - References Stability of Therapeutic Peptides and ProteinsIntroduction - Physical Instability - Chemical Instability - Conclusions - References Formulation of Therapeutic Peptides and ProteinsIntroduction - Formulation Development - Pharmaceutical Excipients in Formulations - Aggregation in Protein Formulations - Novel Formulation Approaches - Accelerated Stability Testing - Conclusions - References Pharmaceutical Processing and Handling of Therapeutic Peptides and ProteinsIntroduction - Protein Destabilization Induced by Pharmaceutical Processing - Lyophilization as a Pharmaceutical Process - Alternate Pharmaceutical Processes - Handling of Therapeutic Peptides and Proteins - Conclusions - References Part II: Drug Delivery SystemsPharmacokinetics of Peptide and Protein DrugsIntroduction - Pharmacokinetic Parameters - Examples of Protein Pharmacokinetics - Other Pharmacokinetic/Pharmacodynamics Considerations - Transport of Peptides Across the Blood-Brain Barrier - Conclusions - References Parenteral Controlled Delivery of Therapeutic Peptides and ProteinsIntroduction - Polymers Used for Controlled Delivery of Peptides and Proteins - Parenteral Controlled Release Systems - Conclusions - References Oral Delivery of Peptide and Protein DrugsIntroduction - Barriers to Protein Absorption and Pathways of Penetration - Approaches to Improve Oral Delivery - Methods to Study Oral Absorption - Oral Immunization - Conclusions - References Transdermal and Topical Delivery of Therapeutic Peptides and ProteinsIntroduction - Approaches to Enhance Transdermal Peptide Delivery - Iontophoresis - Topical Delivery of Therapeutic Peptides and Proteins - Conclusions - References Mucosal Delivery of Therapeutic Peptides and ProteinsIntroduction - Nasal Delivery - Pulmonary Delivery - Rectal Delivery - Buccal Delivery - Ocular Delivery - Comparative Evaluation of Mucosal Routes - Conclusions - References Index
Responsibility: Ajay K. Banga.

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