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Document Type: | Article |
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All Authors / Contributors: | RJ Woods Affiliation: Complex Carbohydrate Research Center, University of Georgia, Athens 30602-4712, USA. |
ISSN: | 0959-440X |
Language Note: | English |
Unique Identifier: | 121412753 |
Awards: |
Abstract:
Oligosaccharides represent a particularly challenging class of molecules for conformational analysis. Recent advances in experimental and theoretical methods have begun to yield further insight into their conformational behavior; however, general rules governing their conformational preferences have not yet emerged. X-ray and NMR techniques may provide vital insights into protein-bound oligosaccharide conformations, but these do not necessarily represent highly populated solution conformations. Moreover, an oligosaccharide's inherent flexibility and lack of strong intermolecular interactions places extreme demands on theoretical methods.
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