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Tissue engineering of temporomandibular joint cartilage

Author: K A Athanasiou
Publisher: [San Rafael, Calif.] : Morgan & Claypool Publishers, ©2009.
Series: Synthesis lectures on tissue engineering, #2.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
The temporomandibular joint (TMJ) is a site of intense morbidity for millions of people, especially young, pre-menopausal women. Central to TMJ afflictions are the cartilaginous tissues of the TMJ, especially those of the disc and condylar cartilage, which play crucial roles in normal function of this unusual joint. Damage or disease to these tissues significantly impacts a patient's quality of life by making common  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Tissue engineering of temporomandibular joint cartilage.
San Rafael : Morgan & Claypool, 2009
(OCoLC)317114552
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: K A Athanasiou
ISBN: 9781598299977 1598299972
OCLC Number: 428747370
Description: 1 online resource (xi, 108 pages) : illustrations (some color).
Contents: The temporomandibular joint --
Tissue engineering --
Anatomy and physiology of the temporomandibular joint --
Development --
Etiology, the TMJ healing problem, and age related changes --
Pathophysiology, catabolism, and osteoarthrosis --
Guidelines for testing and modeling of tissue mechanics --
The biomechanical environment of the TMJ --
Animal models --
Current therapies --
Non-invasive treatments --
Minimally invasive treatments --
TMJ surgical therapies --
Invasive surgical therapies, total joint replacement --
TMJ repair using alloplastic devices --
Past experiences --
Currently approved therapies --
Immune response, immunogenicity, transplants --
Gender paradox --
Fibrocartilage of the TMJ disc --
Introduction --
Anatomy: structure and attachments --
Biochemical content --
Collagen composition and distribution --
Collagen organization --
Elastin --
Proteoglycans and glycosaminoglycans --
Biomechanical properties --
Tensile properties --
Compressive properties --
Shear and frictional properties --
Cell types --
Age-associated changes in the disc --
Cartilage of the mandibular condyle --
Introduction --
Biochemical content --
Collagen composition and distribution --
Collagen organization --
Proteoglycans and glycosaminoglycans --
Biomechanical properties --
Tensile and shear properties --
Compressive properties --
Cell content --
Tissue engineering of the disc --
Introduction --
Previous tissue engineering efforts --
Scaffolds --
Bioactive agents --
Mechanical stimulation and bioreactors --
Tissue engineering of the mandibular condyle --
Introduction --
Cells of the mandibular condylar cartilage --
Mandibular condyle tissue engineering studies --
Current perspectives --
Cell sources for tissue engineering of cartilage --
Primary cells --
Stem cells --
The joint capsule and the synovium --
Design standards for tissue engineering --
Assessments of tissue engineered constructs --
Directions to improve patient outcomes --
Bibliography --
Biography.
Series Title: Synthesis lectures on tissue engineering, #2.
Responsibility: Kyriacos A. Athanasiou [and others].

Abstract:

The temporomandibular joint (TMJ) is a site of intense morbidity for millions of people, especially young, pre-menopausal women. Central to TMJ afflictions are the cartilaginous tissues of the TMJ, especially those of the disc and condylar cartilage, which play crucial roles in normal function of this unusual joint. Damage or disease to these tissues significantly impacts a patient's quality of life by making common activities such as talking and eating difficult and painful. Unfortunately, these tissues have limited ability to heal, necessitating the development of treatments for repair or replacement. The burgeoning field of tissue engineering holds promise that replacement tissues can be constructed in the laboratory to recapitulate the functional requirements of native tissues. This book outlines the biomechanical, biochemical, and anatomical characteristics of the disc and condylar cartilage, and also provides a historical perspective of past and current TMJ treatments and previous tissue engineering efforts. This book was written to serve as a reference for researchers seeking to learn about the TMJ, for undergraduate and graduate level courses, and as a compendium of TMJ tissue engineering design criteria.

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