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Tissue-specific estrogen action : novel mechanisms, novel ligands, novel therapies

Author: Kenneth S Korach; Tim Wintermantel
Publisher: Berlin ; New York : Springer, ©2007.
Series: Ernst Schering Foundation symposium proceedings, 2006/1.
Edition/Format:   eBook : Document : Conference publication : EnglishView all editions and formats
Summary:
Nuclear hormone receptors are not only important drug targets, but have also been the focus of decades of active and highly insightful research. Ten years ago, a review on nuclear receptors was entitled “The Second Decade” and a special issue of Molecular Endocrinology in 2005 dealt with the results of these research efforts. The consensus from nuclear receptor research was of course that the signaling pathways  Read more...
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Genre/Form: Electronic books
Conference papers and proceedings
Congress
Congresses
Additional Physical Format: Print version:
Tissue-specific estrogen action.
Berlin ; New York : Springer, ©2007
(DLC) 2007921596
(OCoLC)144225603
Material Type: Conference publication, Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Kenneth S Korach; Tim Wintermantel
ISBN: 9783540495475 3540495479 9783540495482 3540495487
OCLC Number: 185026959
Description: 1 online resource (xv, 181 pages) : illustrations (some color).
Contents: Interfering with the dynamics of estrogen receptor-regulated transcription / S. Johnsen, S. Kangaspeska, G. Reid and F. Gannon --
Actions of estrogen and estrogen receptors in nonclassical target tissues / E. Murphy and K.S. Korach --
Genetic dissection of estrogen receptor signaling in vivo / T. Wintermantel, J. Elzer, A. Herbison, K.-H. Fritzemeier and G. Schütz --
Of mice and men: the many guises of estrogens / E.R. Simpson and M.E. Jones --
Estradiol action in atherosclerosis and reendothelialization / J.- F. Arnal, H. Laurell, F. Lenfant, V. Douin-Echinard, L. Brouchet and P. Gourdy --
Functional effects and molecular mechanisms of subtype-selective ER[alpha] and ER[beta] agonists in the cardiovascular system / P.A. Arias-Loza, V. Jazbutyte, K.-H. Fritzemeier, C. Hegele-Hartung, L. Neyses, G. Ertl and T. Pelzer --
Pathogenesis and therapy of rheumatoid athritis / R.O. Williams --
The role of ER[alpha] and ER[beta] in the prostate: insights from genetic models and isoform-selective ligands / S.J. McPherson, S.J. Ellem, V. Patchev, K.H. Fritzemeier and G.P. Risbridger --
Preclinical characterization of selective estrogen receptor [beta] agonists: new insights into their therapeutic potential / H.A. Harris --
Exploiting nongenomic estrogen receptor-mediated signaling for the development of pathway-selective estrogen receptor ligands / C. Otto, S. Wessler and K.-H. Fritzemeier.
Series Title: Ernst Schering Foundation symposium proceedings, 2006/1.
Responsibility: K.S. KOrach, T. Wintermantel, editors.

Abstract:

Current molecular understanding of estrogen action has greatly profited from advances in molecular cell biology. These advances, and their implications for clinical use, were discussed by leading  Read more...

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From the reviews:"This summation of a symposium discusses some of the new research developments and estrogen-receptor based therapies that are being tested in the laboratory and in current use. ... Read more...

 
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