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Transgenesis and targeted mutagenesis in immunology

Author: Horst Bluethmann; Pamela S Ohashi
Publisher: San Diego : Academic Press, ©1994.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
Investigations into the field of immunology are rapidly expanding with the use of genetically altered mice at the embryonic stage. This breakthrough laboratory guide provides a complete study of transgenesis and targeted mutagenesis in laboratory mice that will be valued by researchers looking for fresh observations and interpretations when designing future experiments.
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Transgenesis and targeted mutagenesis in immunology.
San Diego : Academic Press, ©1994
(DLC) 93043197
(OCoLC)29361189
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Horst Bluethmann; Pamela S Ohashi
ISBN: 9781483296494 1483296490
OCLC Number: 624588813
Reproduction Notes: Electronic reproduction. [S.l.] : HathiTrust Digital Library, 2010. MiAaHDL
Description: 1 online resource (xx, 316 pages) : illustrations
Details: Master and use copy. Digital master created according to Benchmark for Faithful Digital Reproductions of Monographs and Serials, Version 1. Digital Library Federation, December 2002.
Contents: Transgenic mouse models to study VDJ recombination --
Lymphocyte development and function in T cell receptor and RAG-1 mutant mice --
RAG-2 deficient blastocyst complementation --
Role of CD4 and CD8 in determining cell fate in the thymus --
T cell development in CD4, CD8 and p56 gene-targeted mice --
T cell tolerance in T cell receptor transgenic ipr/ipr mice --
Thymocyte selection and peripheral tolerance using the lymphocyte choriomeningitis virus as a model antigen --
Peripheral T cell tolerance: distinct levels and multistep mechanisms. Peripheral tolerance and CD4 T cells --
Studies of tolerance, inflammation and autoimmunity in transgenic mice --
Immunological studies utilizing cytokine transgenic mice --
Effect of MHC class II encoding transgenes on autoimmunity in nonobese diabetic mice --
Development and function of the immune system in mice with targeted disruption of the interleukin 2 gene --
Immune responses in interleukin 4-deficient mice --
Manipulation of transgene-encoded self-antigens to explore mechanisms of B cell tolerance --
Transgenic mouse model for peripheral B cell tolerance. Immunobiology of MHC class I-deficient mice --
MHC class II mutant mice.
Responsibility: edited by Horst Bluethmann, Pamela S. Ohashi.

Abstract:

A laboratory guide to the study of transgenesis and targetted mutagenesis of laboratory mice. The book also addresses the use of mouse models in studying the immune system, focuses on gene  Read more...

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