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Transgenic animal mutagenicity assays

Author: U WahnschaffeUnited Nations Environment Programme.International Labour Organisation.World Health Organization.Inter-Organization Programme for the Sound Management of Chemicals.All authors
Publisher: Geneva : World Health Organization, 2006.
Series: Environmental health criteria, 233.
Edition/Format:   Print book : Document : International government publication   Computer File : EnglishView all editions and formats
Database:WorldCat
Summary:
This document provides an introduction to the field of transgenic mutagenicity assays and assesses the possible role of these assays in toxicology testing and mechanistic research. Part I gives a short overview of in vivo genotoxicity testing. Part II gives an overview of the data produced by various assays. Part III discusses the use of the assays in research. Part IV evaluates the role and potential added value of  Read more...
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Details

Material Type: Document, Government publication, International government publication, Internet resource
Document Type: Book, Computer File, Internet Resource
All Authors / Contributors: U Wahnschaffe; United Nations Environment Programme.; International Labour Organisation.; World Health Organization.; Inter-Organization Programme for the Sound Management of Chemicals.; International Program on Chemical Safety.
ISBN: 9789241572330 9241572337
OCLC Number: 77516640
Language Note: Summaries in French and Spanish.
Notes: "Published under the joint sponsorship of the United Nations Environment Programme, the International Labour Organisation, and the World Health Organization, and produced within the framework of the Inter-Organization Programme for the Sound Management of Chemicals."
"International Programme on Chemical Safety"--Cover.
Description: xxv, 298 pages : illustrations.
Contents: Part 1. Overview of genotoxicity testing and transgenic animal mutagenicity systems --
Overview of genotoxicity testing --
Constructions/production of transgenic animals using as examples the lacI and lacZ mutation models --
The transgenic mutagenicity assay-methodology using as examples lacI and lacZ mutation models --
Further transgenic mutagenicity assays --
Parameters and criteria for valid experimental design --
Part 2. Comparison of the lacI model and the lacZ model with conventional test systems --
Introduction to part 2 --
Comparison of the Muta (superscript TM) mouse and Big Blue® assays --
Transgenic assays-comparison with other assays --
Transgenic assays and carcinogenicity testing --
Part 3. Applications of transgenic animal mutagenicity studies --
Mutation frequencies and sequencing data and applications of this information in mechanistic studies --
Part 4. Evaluation, conclusions and recommendations --
Evaluation of the transgenic animal mutagenicity assays based on this review of the current literature --
Conclusions --
Recommendations.
Series Title: Environmental health criteria, 233.
Responsibility: first draft prepared by Ulrich Wahnschaffe [and others].

Abstract:

This document provides an introduction to the field of transgenic mutagenicity assays and assesses the possible role of these assays in toxicology testing and mechanistic research. Part I gives a short overview of in vivo genotoxicity testing. Part II gives an overview of the data produced by various assays. Part III discusses the use of the assays in research. Part IV evaluates the role and potential added value of transgenic mutation assays in toxicology and risk assessment. This document is directed at toxicologists, research scientists and risk assessors.--Publisher's description.

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