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Transgenic Models of Human Viral and Immunological Disease

Author: Francis V Chisari; Michael B A Oldstone
Publisher: Berlin, Heidelberg : Springer Berlin Heidelberg, 1996.
Series: Current topics in microbiology and immunology, 206.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Most diseases are multifactoral. Transgenic technology permits gene(s) of interest to be expressed in a small manipulatable laboratory animal model. By this process, murine models of human infections can be developed and studied; effects of cytokines in vivo, focally expressed in unique cells can be established and manipulated, and a variety of autoimmune disorders, mimicking human disease can be constructed. In  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Francis V Chisari; Michael B A Oldstone
ISBN: 9783642852084 3642852084 9783540593416 3540593411
OCLC Number: 851378363
Description: 1 online resource (xi, 345 pages 53 illustrations).
Contents: Cytotoxic T Cell Effector and Memory Function in Viral Immunity --
Transgenic Mouse Models of Experimental Autoimmune Encephalomyelitis --
The Contribution of Insulitis to Diabetes Development in Tumor Necrosis Factor Transgenic Mice --
Influence of T Lymphocytes and Major Histocompatibility Complex Class II Genes on Diabetes Susceptibility in the NOD Mouse --
Virus-Induced Autoimmune Disease: Transgenic Approach to Mimic Insulin-Dependent Diabetes Mellitus and Multiple Sclerosis --
Role of HLA-B27 in Spondyloarthropathies --
The Influence of Cytokines on the Central Nervous System of Transgenic Mice --
Mx Transgenic Mice --
Animal Models of Health --
Hepatitis B Virus Transgenic Mice: Models of Viral Immunobiology and Pathogenesis --
Transgenic Models of HTLV-I Mediated Disease and Latency --
Transgenic Models of Human Immunodeficiency Virus Type-1 --
Transgenic Models in the Study of AIDS Dementia Complex --
Regulation of Expression and Pathogenic Potential of Human Foamy Virus In Vitro and in Transgenic Mice --
Transgenetics of Prion Diseases --
Poliovirus Biology and Pathogenesis --
Safety Requirements for Maintenance and Distribution of Transgenic Mice Susceptible to Human Viruses: The Example of Poliovirus-Susceptible Transgenic Mice.
Series Title: Current topics in microbiology and immunology, 206.
Responsibility: edited by Francis V. Chisari, Michael B.A. Oldstone.

Abstract:

effects of cytokines in vivo, focally expressed in unique cells can be established and manipulated, and a variety of autoimmune disorders, mimicking human disease can be constructed. In this volume,  Read more...

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