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Translational and experimental clinical research

Author: Daniel P Schuster; William J Powers, MD.
Publisher: Philadelphia : Lippincott Williams & Wilkins, ©2005.
Edition/Format:   Print book : EnglishView all editions and formats
Summary:
This volume is a comprehensive textbook for investigators entering the rapidly growing field of translational and experimental clinical research. The book offers detailed guidelines for designing and conducting a study and analyzing and reporting results and discusses key ethical and regulatory issues. Chapters address specific types of studies such as clinical experiments in small numbers of patients,  Read more...
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Details

Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Daniel P Schuster; William J Powers, MD.
ISBN: 0781755654 9780781755658
OCLC Number: 58828632
Description: xxi, 490 pages, [4] pages of plates : illustrations (some color) ; 26 cm
Contents: 1. Defining the research question --
2. Searching the literature --
3. Variables and measurements --
4. Study eligibility and participant selection --
5. Recruiting research participants --
6. Reducing bias --
7. Observational study designs --
8. Experimental study designs --
9. Estimating sample size --
10. Database development --
11. Case report form development --
12. Data collection and quality control --
13. Monitoring experimental interventions --
14. Responsible conduct of research --
15. Regulatory oversight --
16. Funding clinical research --
17. Research budgeting --
18. "Small" clinical experiments --
19. Clinical studies in pediatric minority populations --
20. Pharmacokinetics and pharmacodynamics --
21. Gene therapy and pharmacogenomic studies --
22. Preparing for gene therapy studies --
23. Overview : hypothesis testing and summary statistics --
24. Group comparisons --
25. Regression --
26. Multivariate analysis --
27. Biostatistical consulting --
28. Statistical computing --
29. Presenting data in manuscripts --
30. Visual presentation of data --
31. Fundamentals of gene expression --
32. Identifying mutations and polymorphisms --
33. Cloning methods --
34. Transcriptional profiling --
35. Proteomics --
36. Cell and tissue imaging techniques --
37. Non-imaging cell and tissue techniques and tissue banking --
38. Evaluating substrate metabolism --
39. Medical images as scientific data.
Responsibility: [edited by] Daniel P. Schuster, William J. Powers.
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Abstract:

Offers guidelines for designing and conducting a study and analyzing and reporting results and discusses ethical and regulatory issues. This book contains chapters which address specific types of  Read more...

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