RT Web Page DB /z-wcorg/ DS http://worldcat.org ID 855023001 LA English UL http://site.ebrary.com/id/10740139 T1 TRIM/RBCC proteins A1 Meroni, Germana,, PB Springer Science+Business Media ; Landes Bioscience PP New York; Austin, Tex. YR 2012 SN 9781461453987 1461453984 AB The genomic golden age has delivered the sequence of numerous novel genes while leaving us with many unanswered questions about their function. This is particularly true for gene families as, often, members are annotated based on homology rather than function. The tripartite motif family belonged to this category, although, during the last few years, the field boosted an important wealth of biochemical, cellular and physiological breakthrough data. In the first part of this book, we attempt to offer an overview of stateoftheart basic findings on the tripartite motif (TRIM, also known as RBCC) family members and to deal in the second part with their relevant and growing physiological and pathological roles.