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Tumor antigenicity and approaches to tumor immunotherapy : an outline

Author: David W Weiss
Publisher: Berlin ; New York : Springer-Verlag, 1980.
Series: Current topics in microbiology and immunology, 89.
Edition/Format:   Print book : EnglishView all editions and formats
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Additional Physical Format: Online version:
Weiss, David W., 1927-
Tumor antigenicity and approaches to tumor immunotherapy.
Berlin ; New York : Springer-Verlag, 1980
(OCoLC)741797091
Document Type: Book
All Authors / Contributors: David W Weiss
ISBN: 0387097899 9780387097893 3540097899 9783540097891
OCLC Number: 6205062
Description: viii, 83 pages ; 25 cm.
Contents: 1 Tumor-Associated Antigenicity and Host Responsiveness: Basic Questions and Considerations.- 2 Tumor Etiology and Antigenicity.- 2.1 Tumors Known to be Induced by Viruses.- 2.2 Tumors Known to be Induced by Chemical Agents and by Other Carcinogenic Stimuli.- 2.3 "Spontaneous" Tumors, with No Obvious Viral Etiology (Animal und Human).- 3 Approaches to Immunotherapy.- 3.1 Active "Nonspecific Immunogherapy" with Immunomodulating Agents.- 3.1.1 Loci of Immunomodulator Influence on Antitumor Immune Responses.- 3.1.1.1 Nonspecific Potentiation of Specific Responsiveness to Tumor associated Antigens.- 3.1.1.2 Nonspecific "Spillover" of Potentiated Specific Responsiveness to TAAs.- 3.1.1.3 Nonspecific Potentiation of Specific Immunological Reactions Against Antigens Other than TAAs.- 3.1.1.4 Antigenic Cross-reactivity Between Microbial Immunomodulators and Tumor Cells.- 3.1.1.5 Direct Nonspecific Activation of Immunocytes and Its Nonspecific Consequences.- 3.1.1.6 Nonimmunological Loci of Action of Substances with Immunomodulator Properties.- 3.1.1.7 General Comments.- 3.1.2 Nonliving Immunomodulators of Microbial Origin.- 3.1.3 Intralesional and Regional Versus Distal Immunotherapeutic Administration of Immunomodulators.- 3.1.4 Combined Modalities of Treatment Including Intervention with Nonspecific Immunomodulators.- 3.1.5 Possible Advantages Inherent in the Nonspecific Approach to Tumor Immunotherapy.- 3.2 Active Specific Immunization with Tumor Cell Antigens.- 3.2.1 General Considerations.- 3.2.2 Modification of Tumor Cell Antigens.- 3.2.3 Other Possible Means of Specific Immunization.- 3.3 Passive and Adoptive Immunological Intervention.- 3.3.1 General Considerations.- 3.3.2 In Vitro Generation of Cytotoxic Effector Cells Against Tumors.- 3.3.3 Potentiation of the In Vitro Generation of Cytotoxic Effector Cells.- 3.3.4 In Vitro Production of Antibodies and Its Potentiation.- 3.3.5 Possibilities and Problems of Clinical Application.- 4 Concluding Remarks.- 4.1 Immune Surveillance and Immunological Intervention: Hypothesis and Empiricism.- 4.2 Key Aspects of the Approaches to Tumor Immunotherapy.- 4.3 Goals and Expectations.- 4.4 Experimental Perspectives.- 4.5 Immunological Capacity, Immunological Monitoring, and Susceptibility to Neoplastic Disease.- 4.6 Immunological and Nonimmunological Resistance to Progressive Neoplasia.- 4.7 Coda.- 5 Notes added in Press.- Acknowledgements.- References.
Series Title: Current topics in microbiology and immunology, 89.
Responsibility: David W. Weiss.

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