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Tumor suppressor genes. Volume 223, Part 2, Regulation, function, and medicinal applications

Author: Wafik S El-Deiry
Publisher: Totowa, N.J. : Humana Press, ©2003.
Series: Methods in molecular biology (Clifton, N.J.), volume 223, pt. 2.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Powerful new tools are now available to discover and understand tumor suppressor genes (TSGs) and the biochemical mechanisms by which they control cancer development and progression. In Tumor Suppressor Genes, Volume 2: Regulation, Function, and Medicinal Applications, leading physician scientists and researchers explore the cell biology and biochemical function of the tumor suppressor genes, as well as their  Read more...
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Genre/Form: Electronic books
Laboratory manuals
Laboratory Manuals
Additional Physical Format: Print version:
Tumor suppressor genes.
Totowa, N.J. : Humana Press, ©2003
(DLC) 2002027501
(OCoLC)50339981
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Wafik S El-Deiry
ISBN: 9781592593293 1592593291
OCLC Number: 171188624
Description: 1 online resource (xix, 657 pages) : illustrations.
Series Title: Methods in molecular biology (Clifton, N.J.), volume 223, pt. 2.
Other Titles: Regulation, function, and medicinal applications
Responsibility: edited by Wafik S. El-Deiry.

Abstract:

Powerful new tools are now available to discover and understand tumor suppressor genes (TSGs) and the biochemical mechanisms by which they control cancer development and progression. In Tumor Suppressor Genes, Volume 2: Regulation, Function, and Medicinal Applications, leading physician scientists and researchers explore the cell biology and biochemical function of the tumor suppressor genes, as well as their physiological role in vivo. The authors detail the physical methods-NMR, microarray approaches, posttranslational structure analysis, analysis of regulation at the gene expression and protein signaling levels-used to understand the function of tumor suppressor genes. In vivo approaches discussed include studies in yeast, Drosophila, mice, and human tumors. The authors also discuss how one ultimately derives a "tumor progression model," the drug discovery process, and the weaknesses of cancers that allow drugs to selectively kill them. Other aspects reviewed include screening strategies, targeting the blood supply of tumors, and the replacement of defective cancer genes to achieve a therapeutic effect. The companion volume of this set, Tumor Suppressor Genes, Volume 1: Pathways and Isolation Strategies, covers all known tumor suppressor genes, describing their cellular signaling pathways, how they were discovered, how they can be analyzed, and how they can be optimally used in cancer therapeutics Comprehensive and authoritative, the two volumes of Tumor Suppressor Genes provide an unparalleled compilation of key data on all known tumor suppressor pathways and a treasury of techniques for their discovery, analysis, and uses in cancer therapeutics.

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