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| Genre/Form: | Electronic books |
|---|---|
| Additional Physical Format: | (OCoLC)60821526 |
| Material Type: | Internet resource |
| Document Type: | Internet Resource, Computer File |
| All Authors / Contributors: |
Ann M Dvorak |
| ISBN: | 1423713842 9781423713845 9783805578646 3805578644 9783318011753 3318011754 9786610513581 6610513589 |
| OCLC Number: | 647540987 |
| Description: | 1 online resource (xi, 351 p.) : 185 fig. (4 col.) |
| Contents: | Ultrastructure analysis is necessary and sufficient for identification of basophils and mast cells -- Cyclooxygenase, a key enzyme family for production of prostaglandins, is present in human mast cell lipid bodies -- Subcellular localization of the cytokines, basic fibroblast growth factor and tumor necrosis factor-alpha in mast cells -- Immunogold ultrastructural techniques identify subcellular sites of chymase, charcot-leyden crystal protein, and histamine in basophils and mast cells -- Ultrastructural enzyme-affinity-gold and inhibitor-gold techniques identify subcellular sites of histamine and heparin in basophils and mast cells -- Piecemeal degranulation of basophils and mast cells is effected by vesicular transport of stored secretory granule contents -- Mast cell-derived mediators of enhanced microvascular permeability, vascular permeability factor/ vascular endothelial growth factor, histamine, and serotonin, cause leakage of macromolecules through a new endothelial cell permeability organelle, the vesiculo-vacuolar organelle -- Degranulation and recovery from degranulation of basophils and mast cells -- Mast cell secretory granules and lipid bodies contain the necessary machinery important for the in situ synthesis of proteins. |
| Series Title: | Chemical immunology and allergy, v. 85. |
| Responsibility: | Ann M. Dvorak. |
Abstract:
Basophils and mast cells are similar but unique secretory cells which play a central role in inflammatory and immediate allergic reactions. In this book, the author reviews the ultrastructural studies of basophils and mast cells performed since the publication of an earlier monograph in 1991. These studies include the use of ultrastructural rules that allow identification of basophils and mast cells in new circumstances. The secretory granules and lipid bodies present in these cells are established as different, important organelles. A number of standard and newly developed ultrastructural ima
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