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Urinary Enzymes : in Clinical and Experimental Medicine

Author: Klaus Jung; Hermann Mattenheimer; Ulf Burchardt
Publisher: Berlin, Heidelberg : Springer Berlin Heidelberg, 1992.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Database:WorldCat
Summary:
The book provides a comprehensive uptodate review of the present state of knowledge of urinary enzymes. Since it deals with all the essential questions currently being discussed in connection with urinary enzymes, it will be of interest to biochemists, clinical chemists, renal physiologists, nephrologists and clinicians working on renal problems. The chapters are grouped into 5 parts, the first offeringan update of  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Klaus Jung; Hermann Mattenheimer; Ulf Burchardt
ISBN: 9783642843136 3642843131
OCLC Number: 851380602
Description: 1 online resource (xviii, 326 pages 71 illustrations)
Contents: 1 Biochemical, Pathobiochemical, and Morphological Fundamentals of the Excretion of Urinary Enzymes --
1 Origin of Enzymes in Urine --
2 Distribution of Diagnostically Relevant Enzymes Along the Nephron --
3 Mechanisms of Enzyme Release and Causes of Altered Enzyme Excretion --
4 Enzymuria as an Indicator of Renal Pathomorphology --
5 Physiological Factors Influencing Enzyme Excretion --
2 Methodological Fundamentals of the Activity Determination of Urinary Enzymes --
6 Preanalytical Treatment of Urine --
7 Quality Assurance --
8 Methods for Measuring Urinary Enzyme Activities --
9 Basis of Reference --
10 Reference Intervals --
3 Urinary Enzymes in Clinical Medicine --
11 Clinical Interpretation of Urinary Enzyme Excretion --
12 Urinary Enzymes in Renal, Renal-Associated and Urological Disorders --
13 Urinary Enzymes in Kidney Transplantation --
14 Urinary Enzymes and Nephrotoxicity in Humans --
15 Extrarenal Diseases --
4 Urinary Enzymes in Animal Experiments --
16 Animal Models --
17 Reference Values --
18 Influence of Different Substances on Urinary Enzyme Excretion --
5 Nephrotoxicity --
19 Renal Enzymes as the Basis for Alternative Methods of Safety Screening In Vitro and Understanding the Mechanism of Nephrotoxicity.
Responsibility: edited by Klaus Jung, Hermann Mattenheimer, Ulf Burchardt.

Abstract:

The book provides a comprehensive uptodate review of the present state of knowledge of urinary enzymes. Since it deals with all the essential questions currently being discussed in connection with urinary enzymes, it will be of interest to biochemists, clinical chemists, renal physiologists, nephrologists and clinicians working on renal problems. The chapters are grouped into 5 parts, the first offeringan update of the biochemical and morphological fundamentals of the excretionof urinary enzymes, including a description of the distribution of diagnostically relevant enzymes along the nephron, the mechanisms of enzyme release, and the physiological factors influencing the excretion rate. The chapters in the second part deal with the methodological fundamentals ofthe activity determination of urinary enzymes (preanalytical treatment, quality assurance, methodical details for the most important enzymes, reviewon reference intervals). The four chapters in the third part review aspects of urinary enzyme excretion in clinical medicine (renal, renal associated, and urological disorders, kidney transplantation, nephrotoxicity, extrarenal diseases) and includes a special chapter on the general background for interpreting data on urinary enzyme excretion. The fourth part, consisting of 3 chapters, covers urinary enzymes in animal experiments (animal models, influence of different substances on urinary enzyme excretion, reference values in various animals). The book concludes with a review of the posibilities for using renal enzymes as the basis for alternative methods of screening toxic substances.

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