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Using 21st century science to improve risk-related evaluations

Author: National Academies of Sciences, Engineering, and Medicine (U.S.). Committee on Incorporating 21st Century Science into Risk-Based Evaluations,
Publisher: Washington, DC : National Academies Press, [2017]
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Over the last decade, several large-scale United States and international programs have been initiated to incorporate advances in molecular and cellular biology, -omics technologies, analytical methods, bioinformatics, and computational tools and methods into the field of toxicology. Similar efforts are being pursued in the field of exposure science with the goals of obtaining more accurate and complete exposure  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
National Academies of Sciences, Engineering, and Medicine (U.S.). Committee on Incorporating 21st Century Science into Risk-Based Evaluations.
Using 21st century science to improve risk-related evaluations.
Washington, DC : The National Academies Press, [2017]
(OCoLC)968317819
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: National Academies of Sciences, Engineering, and Medicine (U.S.). Committee on Incorporating 21st Century Science into Risk-Based Evaluations,
ISBN: 9780309453486 0309453488 9780309453493 0309453496
OCLC Number: 973022022
Description: 1 online resource (1 PDF file (xvi, 179 pages)) : illustrations.
Contents: Introduction --
Advances in exposure science --
Advances in toxicology --
Advances in epidemiology --
A new direction for risk assessment and applications of 21st century science --
Model and assay validation and acceptance --
Interpretation and integration of data and evidence for risk-based decision-making --
Appendix A: Biographical information on the Committee on Incorporating 21st century Science into Risk-Based Evaluations --
Appendix B: Case studies on chemical assessments --
Appendix C: Case studies on site-specific assessments --
Appendix D: Case study on assessment of new chemistry --
Appendix E: A Bayesian Example: predicting dose response relationships from high-throughput data and chemical structure.
Responsibility: Committee on Incorporating 21st Century Science into Risk-Based Evaluations, Board on Environmental Studies and Toxicology, Division on Earth and Life Studies ; a report of National Academies of Sciences, Engineering, and Medicine.

Abstract:

Over the last decade, several large-scale United States and international programs have been initiated to incorporate advances in molecular and cellular biology, -omics technologies, analytical methods, bioinformatics, and computational tools and methods into the field of toxicology. Similar efforts are being pursued in the field of exposure science with the goals of obtaining more accurate and complete exposure data on individuals and populations for thousands of chemicals over the lifespan; predicting exposures from use data and chemical-property information; and translating exposures between test systems and humans. Using 21st Century Science to Improve Risk-Related Evaluations makes recommendations for integrating new scientific approaches into risk-based evaluations. This study considers the scientific advances that have occurred following the publication of the NRC reports Toxicity Testing in the 21st Century: A Vision and a Strategy and Exposure Science in the 21st Century: A Vision and a Strategy. Given the various ongoing lines of investigation and new data streams that have emerged, this publication proposes how best to integrate and use the emerging results in evaluating chemical risk. Using 21st Century Science to Improve Risk-Related Evaluations considers whether a new paradigm is needed for data validation, how to integrate the divergent data streams, how uncertainty might need to be characterized, and how best to communicate the new approaches so that they are understandable to various stakeholders.

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