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Using animal models in biomedical research : a primer for the investigator

Author: Pierce K H Chow; Robert T H Ng; Bryan E Ogden
Publisher: Singapore : World Scientific, ©2008.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Animal models play crucial roles in the continuum of experimental activities that make up biomedical research. Such in vivo modes are especially important in proof-of-principle experiments and in establishing the preclinical safety and efficacy data required for progressing to human clinical trials. A practical understanding of the choice, care and use of animal models is thus expected and required of all biomedical  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Print version:
Chow, Pierce K.H.
Using animal models in biomedical research.
Singapore : World Scientific, ©2008
(DLC) 2008297674
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Pierce K H Chow; Robert T H Ng; Bryan E Ogden
ISBN: 9812812024 9789812812025 9789812706638 9812706631 1281960888 9781281960887
OCLC Number: 313651382
Description: 1 online resource (xviii, 290 pages) : illustrations (some color)
Contents: 1. Scientific considerations and choice of species. The rationale for the use of animal models in biomedical research / Pierce Chow. Experimental animal models in biomedical resarch / Robert Ng. Nonhuman primates as models in biomedical research / Jason Vilano and Bryan Ogden --
2. Regulatory considerations in the use of animal models. Laws, regulations and guidelines for biomedical research in Singapore / Boon Theng Kuah. The functions of the institutional animal care and use committee / Pierce Chow. Responsibilities of principal investigators and research protocol evaluation / Hock Soo Ong. The 3r's, research variables and the use of alternatives / Hock Soo Ong. Use of statistics as determinant for number of animals used / Huihua Li. The advantages of accreditation with AAALAC / Bryan Ogden --
3. Animal handling and surgical procedures. General handling, restraint, oral dosing/gavage and injections in laboratory animals / Bryan Ogden. Blood collection from laboratory animals / Jason Villano. Antibiotic coverage and therapy / Darvi Sergio. Animal preparation and transport / Robert Ng. Preparation and implementation of animal surgery / Robert Ng. Animal intubation / Robert Ng. Anaesthesia and maintenance of homeostasis / Robert Ng. animal euthanasia / Darvi Sergio. Rodent sentinel programme / Peik Khin Tan. 4. Basic animal investigative methods. Bioimaging in animals / David Ng [and others]. Histology sampling and techniques / In Chin Song. Animal tissue perfusion and preservation / Robert Ng. Animal cell culture / Peggy Yong and Kai Zhang. Application of microsurgical techniques in animal research / Bien Keem Tan [and others] --
5. Animal welfare considerations. Species specific caging configuration and design / Cindy Phua. Postoperative care and pain management / Jason Villano. animal feeds and nutritional requirements / Peik Khin Tan --
6. Safety management of an animal facility. Occupational health and safety programme / Angela Goh. New employee and external users orientation / Inria Kurniawan Then. Radiation safety awareness in animal research / S. Somanesan. Emergency crisis management / Irene Kee. Zoonoses and laboratory animal allergies / Jason Villano --
7. Supporting facilities design. clinical skills laboratory / Robert Ng. Animal research supporting laboratories / Robert Ng. animal research and housing facilities / Robert Ng --
8. The development of comprehensive animal facilities in Singapore. History of the Department of Experimental Surgery as a reflection of translational research development in Singapore / Robert Ng --
Append. 1. Accredited laboratories for import of experimental animals --
Append. 2. Radiation safety data --
Append. 3. Anaesthesia for laboratory animals --
Append. 4. Analgesics and therapeutics for laboratory animals --
Append. 5. Passively transmitted zoonotic organisms.
Responsibility: Pierce K.H. Chow, Robert T.H. Ng, Bryan E. Ogden.

Abstract:

Animal models play crucial roles in the continuum of experimental activities that make up biomedical research. This book provides information on bioimaging, occupational health and biosafety, animal  Read more...

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