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Valproate

Author: Wolfgang Löscher
Publisher: Basel : Birkhäuser Basel : Imprint : Birkhäuser, 1999.
Series: Milestones in drug therapy.
Edition/Format:   eBook : Document : EnglishView all editions and formats
Summary:
Valproic acid was first synthesized in 1882 by Burton, but there was no known clinical use until its anticonvulsant activity was fortuitously discovered by H. Meunier in 1963 in the laboratory of G. Carraz. The first clinical trials of the sodium salt of valproate were reported in 1964 by Carraz. It was marketed in France in 1967 and was released in the United States in 1978 for the treatment of epilepsy. Since  Read more...
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Genre/Form: Electronic books
Additional Physical Format: Printed edition:
Material Type: Document, Internet resource
Document Type: Internet Resource, Computer File
All Authors / Contributors: Wolfgang Löscher
ISBN: 9783034887595 3034887590 9783034897617 3034897618
OCLC Number: 840291141
Description: 1 online resource.
Contents: The discovery of valproate --
The pharmacology of valproate --
Pharmacological effects and mechanisms of action --
Chemistry and biotransformation --
Absorption, distribution and excretion --
Toxicity --
Clinical use of valproate --
Valproate in the treatment of epilepsies in children --
Treatment of epilepsies in adults --
Valproate use in psychiatry: A focus on bipolar illness --
Valproate in the treatment of headache --
Adverse effects and interactions with other drugs --
The future of valproate.
Series Title: Milestones in drug therapy.
Responsibility: edited by Wolfgang Löscher.

Abstract:

In this volume on valproate emphasis is placed on the scientific back- ground leading to the discovery of val pro ate, its subsequent pharmacologi- cal and toxicological characterization, and its  Read more...

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