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What's wrong with my mouse? : behavioral phenotyping of transgenic and knockout mice

Author: Jacqueline N Crawley
Publisher: New York : Wiley-Liss, ©2000.
Edition/Format:   Print book : EnglishView all editions and formats
Summary:
"Transgenic and knockout mutations provide an important means for understanding gene function, as well as for developing therapies for genetic diseases. This book discusses the many advances in the field of transgenic technology that have enabled researchers to bring about various changes in the mouse genome. Equal emphasis is given to both the principles of transgenic and knockout methods and their applications. A  Read more...
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Additional Physical Format: Online version:
Crawley, Jacqueline N.
What's wrong with my mouse?
New York : Wiley-Liss, ©2000
(OCoLC)606280545
Online version:
Crawley, Jacqueline N.
What's wrong with my mouse?
New York : Wiley-Liss, ©2000
(OCoLC)607786824
Material Type: Internet resource
Document Type: Book, Internet Resource
All Authors / Contributors: Jacqueline N Crawley
ISBN: 0471316393 9780471316398
OCLC Number: 41156560
Notes: "Published simultaneously in Canada"--Title page verso.
Description: xiii, 329 pages : illustrations ; 26 cm
Contents: Designer mice --
Of unicorns and chimeras --
General health --
Motor functions --
Sensory abilities --
Learning and memory --
Feeding and drinking --
Reproductive behaviors --
Social behaviors --
Emotional behaviors --
Reward --
The next generation.
Responsibility: Jacqueline N. Crawley.
More information:

Abstract:

Transgenic and knockout mutations provide a tremendously important means for understanding gene function, as well as for developing therapies for genetic diseases. This work discusses the effects of  Read more...

Table of Contents:

by belleopsis (WorldCat user on 2006-04-11)

Designer Mice: Scope and Sourcebooks. Of Unicorns and Chimeras: How to Generate a Transgenic or Knockout Mouse General Health: Give Your Mouse a Physical; Neurological Reflexes. Motor Functions: Open Field, Holeboard, Rotarod, Balance, Grip, Circadian Activity, Circling, Stereotypy, Ataxic Gait, Seizures. Sensory Abilities: Olfaction, Vision, Hearing, Taste, Touch, Nociception. Learning and Memory: Morris Swim Task, Spatial Mazes, Cued and Contextual Conditioning, Conditioned Taste Aversion, Conditioned Eye Blink, Olfactory Discrimination, Social Recognition, Passive Avoidance, Schedule Controlled Operant Tasks, Motor Learning. Feeding and Drinking: Daily Consumption, Restricted Access, Choice Tests, Microstructural Analysis. Reproductive Behaviors: Sexual and Parental Behaviors. Social Behaviors: Social Interaction, Nesting, Grooming, Juvenile Play, Aggression. Emotional Behaviors: Animal Models of Psychiatric Disorders: Fear, Anxiety, Depression, Schizophrenia. Reward: Self-Administration of Additive Drugs, Conditioned Place Preference. The Next Generation: Conditional and Inducible Mutations, Quantitative Trait Loci Analysis, Chemical Mutagenesis, Gene Therapy, Ethical Issues. Bibliography. Index.

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"...this valuable book is currently the most complete overview of behavioral procedures available...it is a must have and a must read book..." (Genes, Brain, and Behavior, 2002)

 
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