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The world of the cell.

Author: Wayne M Becker; Lewis J Kleinsmith; Jeff Hardin
Publisher: San Francisco : Benjamin Cummings, ©2000.
Edition/Format:   Print book : English : 4th ed.View all editions and formats
Summary:
This book is intended as a comprehensive introduction to cellular and molecular biology for students preparing for careers in biology, medicine and related fields. Its goal is to present essential principles, processes and methodology.
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Additional Physical Format: Online version:
Becker, Wayne M.
World of the cell.
San Francisco : Benjamin Cummings, ©2000
(OCoLC)746103630
Document Type: Book
All Authors / Contributors: Wayne M Becker; Lewis J Kleinsmith; Jeff Hardin
ISBN: 0805344888 9780805344882
OCLC Number: 41977286
Description: xxxii, 878 pages : illustrations (some color) ; 29 cm
Contents: Part I. The world of the cell: an overview of structure and function. [Ch.1] A preview of the cell --
The cell theory: a brief history --
The emergence of modern cell biology --
Box 1A: units of measurement in cell biology --
Box 1B: further insights: biology, "facts" and the scientific method --
[Ch.2] The chemistry of the cell --
The importance of carbon --
The importance of water --
The importance of selectively permeable membranes --
The importance of synthesis by polymerization --
The importance of self-assembly --
Box 2A: further insights: tempus fugit and the fine art of watchmaking --
[Ch.3] The macromolecules of the cell --
Proteins --
Nucleic acids --
Polysaccharides --
Lipids --
Box 3A: historical perspectives: on the trail of the double helix --
[Ch.4] Cells and organelles --
Properties and strategies of cells --
The eukaryotic cell in overview: pictures at an exhibition --
Viruses, viroids, and prions: agents that invade cells --
Box 4A: historical perspectives: discovering organelles: the importance of centrifuges and chance observation. [Ch.5] Bioenergetics: the flow of energy in the cell --
The importance of energy --
Bioenergetics --
Understanding AG --
Life and the steady state: reactions that move toward equilibrium without ever getting there --
Box 5A: further insights: jumping beans and free energy --
Box 5B: historical perspectives: energy and entropy: the Greek connection --
[ch.6] Enzymes: the catalysts of life --
Activation energy and the metastable state --
Enzymes as biological catalysts --
Enzyme kinetics --
Enzyme regulation --
RNA molecules as enzymes: ribozymes --
Box 6A: further insights: monkeys and peanuts --
Box 6B: historical perspective: ATCase: experimental support for allosteric regulation --
Part III. Membranes and cell signaling. [Ch.7] Membranes: their structure, function, and chemistry --
The functions of membranes --
Models of membrane structure: an experimental perspective --
Membrane lipids: the "fluid" part of the model --
Membrane proteins: the "mosaic" part of the model --
Box 7A: contemporary techniques: revolutionizing the study of membrane proteins: the impact of molecular biology. [Ch. 8] Transport across membranes: overcoming the permeability barrier --
Cells and transport processes --
Simple diffusion: unassisted movement down the gradient --
Facilitated diffusion: protein-mediated down the gradient --
Active transport: protein-mediated movement up the gradient --
Examples of active transport --
The energetics of transport --
On to nerve cells --
Box 8A: further insights: osmosis: the special case of water transport --
Box 8B: clinical applications: membrane transport, cystic fibrosis, and the prospects for gene therapy --
[Ch. 9] Signal transduction mechanisms: I. Electrical signals in nerve cells --
The nervous system --
Understanding membrane potential --
Electrical excitability --
The action potential --
Synaptic transmission --
Integration and processing of nerve signals --
Box 9A: clinical applications: poisoned arrows, snakebites and nerve gases --
[Ch. 10] Signal transduction mechanisms: II. Messengers and receptors --
Chemical signals and cellular receptors --
G protein: linked receptors --
Protein kinase: associated receptors --
Growth factors as messengers --
The endocrine and paracrine hormone systems --
Box 10A: further insights: g proteins and vision --
Box 10B: further insights: cell signals and programmed cell death. [Ch. 11] Beyond the cell: extracellular structures, cell adhesion, and cell junctions --
The extracellular matrix of animal cells --
Fibronectins bind cells to the matrix and guide cellular movement --
Cell-cell recognition and adhesion --
Cell junctions --
The plant cell surface --
Box 11A: clinical applications: understanding blood type: a matter of molecular recognition --
[Ch. 12] Intracellular compartments: the endoplasmic reticulum, golgi complex, endosomes, lysosomes, and peroxisomes --
The endoplasmic reticulum --
The golgi complex --
Roles of the ER and golgi complex in protein glycosylation --
Roles of the ER and golgi complex in protein sorting --
Exocytosis and endocytosis: transporting material across the plasma membrane --
Coated vesicles in cellular transport processes --
Lysosomes and cellular digestion --
The plant vacuole: a multifunctional organelle --
Peroxisomes --
Box 12A: contemporary techniques: centrifugation: an indispensable technique of cell biology --
Box 12B: clinical applications: cholesterol, the LDL receptor, and receptor-mediated endocytosis --
Part III. Energy flow in cells. [Ch.13] Chemotrophic energy metabolism: glycolysis and fermentation --
Metabolic pathways --
ATP: the universal energy coupler --
Chemotrophic energy metabolism --
Glycolysis and fermentation: ATP generation without the involvement of oxygen --
Alternative substrates for glycolysis --
Gluconeogenesis --
The regulation of glycolysis and gluconeogenesis --
Box 13A: further insights: "what happens to the sugar?" --
[Ch.14] Chemotrophic energy metabolism: aerobic respiration --
Cellular respiration: maximizing ATP yields --
The mitochondrion: where the action takes place --
The tricarboxylic acid cycle: oxidation in the round --
Electron transport: electron flow from coenzymes to oxygen --
The electrochemical proton gradient: key to energy coupling --
ATP synthesis: putting it all together --
Aerobic respiration: summing it all up --
Box 14A: further insights: the glyoxylate cycle, glyoxysomes, and seed germination --
[Ch.15] Phototrophic energy metabolism: photosynthesis --
An overview of photosynthesis --
The chloroplast: a photosynthetic organelle --
Photosynthetic energy transduction --
Photoreduction (NADPH synthesis) in oxygenic phototrophs --
Photophosphorylation (ATP synthesis) in oxygenic phototrophs --
A photosynthetic reaction center from a purple bacterium --
Photosynthetic carbon assimilation: the calvin cycle --
Photosynthetic energy transduction and the calvin cycle --
Carbohydrate synthesis --
Other photosynthetic assimilation pathways --
Rubisco's oxygenase activity decreases photosynthetic efficiency --
Box 15A: further insights: the endosymbiont theory and the evolution of mitochondria and chloroplasts from ancient bacteria --
Part IV. Information flow in cells. [Ch. 16] The structural basis of cellular information: DNA chromosomes, and the nucleus --
The chemical nature of the genetic material --
DNA structure --
The organization of DNA in genomes --
DNA packaging --
The nucleus --
Box 16A: further insights: phages: model systems for studying genes --
Box 16B: further insights: a closer look at restriction enzymes --
Box 16C: contemporary techniques: DNA fingerprinting --
[Ch. 17] The cell cycle: DNA replication, mitosis, and cancer --
An overview of the cell cycle --
DNA replication --
DNA damage and repair --
Nuclear and cell division --
Regulation of the cell cycle --
Growth control and cancer --
Box 17A: contemporary techniques: the PCR revolution --
Box 17B: clinical applications: attacking a tumor's blood supply --
[Ch. 18] Sexual reproduction, melosis, and genetic recombination --
Sexual reproduction --
Meiosis --
Genetic variability: segregation and assortment of alleles --
Genetic variability: recombination and crossing over --
Genetic recombination in bacteria and viruses --
Molecular mechanism of homologous recombination --
Recombinant DNA technology and gene cloning --
Genetic engineering --
Box 18A: historical perspectives: supermouse, an early transgenic triumph. [Ch. 19] Gene expression: I. The genetic code and transcription --
The directional flow of genetic information --
The genetic code --
Transcription in prokaryotic cells --
Transcription in eukaryotic cells --
RNA processing --
Key aspects of MRNA metabolism --
Box 19A: further insights: reverse transcription, retroviruses, and retrotransposons --
Box 19B: contemporary techniques: the footprinting method for identifying protein-binding sites on DNA --
[Ch. 20] Gene expression: II. Protein synthesis and sorting --
Translation: the cast of characters --
The mechanism of translation --
Nonsense mutations and suppressor TRNA --
Posttranslational processing --
Protein targeting and sorting --
Box 20A: clinical applications: protein-folding diseases --
Box 20B: a mutation primer --
[Ch. 21] The regulation of gene expression --
Gene regulation in prokaryotes --
Comparison of gene regulation in prokaryotes and eukaryotes --
Eukaryotic gene regulation: genomic control --
Eukaryotic gene regulation: transcriptional control --
Eukaryotic gene regulation: posttranscriptional control --
Box 21A: further insights: dolly: a lamb with no father --
Box 21B: contemporary techniques: discriminating among multiple levels of control --
Part V. The cytoskeleton and cell motility. [Ch. 22] Cytoskeletal systems --
The major structural elements of the cytoskeleton --
Techniques for studying the cytoskeleton --
Microtubules --
Microfilaments --
Intermediate filaments --
The cytoskeleton and the tensegrity architecture of cells --
Box 22A: clinical applications: intermediate filaments and the diagnosis of tumors --
[Ch. 23] Cellular movement: motility and contractility --
Motile systems --
Intracellular microtubule-based movement: kinesin and dynein --
Microtubule-based motility --
Actin-based cell movement: the myosins --
Filament-based movement in muscle --
Actin-based motility in nonmuscle cells --
Box 23A: clinical applications: cytoskeletal motor proteins and human disease --
Appendix: principles and techniques of microscopy --
Optical principles of microscopy --
The light microscope --
Sample preparation techniques for light microscopy --
The electron microscope --
Sample preparation techniques for electron microscopy --
Other imaging methods --
Key terms for self-testing --
Suggested reading.

Abstract:

Focussing on the key concepts, this work aims to provide students with a comprehensive understanding of cell biology without being overwhelming. The fourth edition contains increased coverage of  Read more...

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   schema:description "[Ch.5] Bioenergetics: the flow of energy in the cell -- The importance of energy -- Bioenergetics -- Understanding AG -- Life and the steady state: reactions that move toward equilibrium without ever getting there -- Box 5A: further insights: jumping beans and free energy -- Box 5B: historical perspectives: energy and entropy: the Greek connection -- [ch.6] Enzymes: the catalysts of life -- Activation energy and the metastable state -- Enzymes as biological catalysts -- Enzyme kinetics -- Enzyme regulation -- RNA molecules as enzymes: ribozymes -- Box 6A: further insights: monkeys and peanuts -- Box 6B: historical perspective: ATCase: experimental support for allosteric regulation -- Part III. Membranes and cell signaling. [Ch.7] Membranes: their structure, function, and chemistry -- The functions of membranes -- Models of membrane structure: an experimental perspective -- Membrane lipids: the "fluid" part of the model -- Membrane proteins: the "mosaic" part of the model -- Box 7A: contemporary techniques: revolutionizing the study of membrane proteins: the impact of molecular biology."@en ;
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   schema:description "[Ch. 19] Gene expression: I. The genetic code and transcription -- The directional flow of genetic information -- The genetic code -- Transcription in prokaryotic cells -- Transcription in eukaryotic cells -- RNA processing -- Key aspects of MRNA metabolism -- Box 19A: further insights: reverse transcription, retroviruses, and retrotransposons -- Box 19B: contemporary techniques: the footprinting method for identifying protein-binding sites on DNA -- [Ch. 20] Gene expression: II. Protein synthesis and sorting -- Translation: the cast of characters -- The mechanism of translation -- Nonsense mutations and suppressor TRNA -- Posttranslational processing -- Protein targeting and sorting -- Box 20A: clinical applications: protein-folding diseases -- Box 20B: a mutation primer -- [Ch. 21] The regulation of gene expression -- Gene regulation in prokaryotes -- Comparison of gene regulation in prokaryotes and eukaryotes -- Eukaryotic gene regulation: genomic control -- Eukaryotic gene regulation: transcriptional control -- Eukaryotic gene regulation: posttranscriptional control -- Box 21A: further insights: dolly: a lamb with no father -- Box 21B: contemporary techniques: discriminating among multiple levels of control -- Part V. The cytoskeleton and cell motility."@en ;
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   schema:description "[Ch. 16] The structural basis of cellular information: DNA chromosomes, and the nucleus -- The chemical nature of the genetic material -- DNA structure -- The organization of DNA in genomes -- DNA packaging -- The nucleus -- Box 16A: further insights: phages: model systems for studying genes -- Box 16B: further insights: a closer look at restriction enzymes -- Box 16C: contemporary techniques: DNA fingerprinting -- [Ch. 17] The cell cycle: DNA replication, mitosis, and cancer -- An overview of the cell cycle -- DNA replication -- DNA damage and repair -- Nuclear and cell division -- Regulation of the cell cycle -- Growth control and cancer -- Box 17A: contemporary techniques: the PCR revolution -- Box 17B: clinical applications: attacking a tumor's blood supply -- [Ch. 18] Sexual reproduction, melosis, and genetic recombination -- Sexual reproduction -- Meiosis -- Genetic variability: segregation and assortment of alleles -- Genetic variability: recombination and crossing over -- Genetic recombination in bacteria and viruses -- Molecular mechanism of homologous recombination -- Recombinant DNA technology and gene cloning -- Genetic engineering -- Box 18A: historical perspectives: supermouse, an early transgenic triumph."@en ;
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