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CLARKSON UNIV POTSDAM NY
Overview
| Works: | 31
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34
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1
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34
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Most widely held works by
CLARKSON UNIV POTSDAM NY
Substrate Induced Conformational Studies of the Hormone Binding Domain of the Human Estrogen Receptor by Fluorine NMR(
图书
)
3
editions published
between
1997
and
2000
in
英语
and held by
1
library
worldwide
Estrogen has been shown to be involved in the progression of breast cancer and the estrogen receptor (ER) has been implicated in reproductive cancers. Our laboratory would like to understand how the structure of the hormone binding domain (HBD) of the ER changes when it is "activated" by estrogens and antiestrogens. Since the binding of estradiol to its receptor ultimately leads to diverse biological responses to the hormone, we would like to investigate the response of the receptor to a series of ligands and illucidate the molecular basis for their functional differences. This proposal will characterize the critical substrate induced conformational changes in the HBD by incorporating fluorine labels into recombinate constructs and performing fluorine nuclear magnetic resonance (NMR) studies. We will examine whether estrogens and antiestrogens produce similar conformational effects on the receptor and will compare these changes to those induced by "environmental" estrogens. The purpose of this proposal is to provide and understand the conformational changes in HBD, which will shed light on the molecular events of substrate binding, transcriptional activation and the role of environmental estrogens in receptor function.
Eigenvectors of Graphs(
图书
)
2
editions published
between
1986
and
1988
in
英语
and held by
1
library
worldwide
This grant has supported work in several areas. 1) A study of graph eigenvectors shows connections to graph structure in ways that are reminiscent of eigenfunctions of the laplacian operator in two or three dimensions. Methods developed in this study have also led to estimates of the maximum possible value for the kth eigenvalue of a graph as function of the number of edges or vertices. 2) The convex hull of the rows of an eigenmatrix of a graph is the polytope of an eigenvalue. We investigated relations between such polytopes and the graph. The graph of such a polytope may be isomorphic to the original graph this is the case for most regular polytopes. For distance-regular graphs and several kinds of less symmetric graphs, we can show that the polytope of some eigenvalue has the same group of automorphisms as the graph, that proximity of points is equivalent to adjacency of vertices, and that other properties of the polytope carry over the graph. Possible directions for future work include the following. Determine the reducibility of the group of automorphisms of a polytope and the significance in the graph of faces and facets of the polytopes. Investigate the intrinsic eigenvectors of a graph (the list of inner products of vertices of a polytope with the normal to a supporting hyperplane is an intrinsic eigenvector). Seek physical models for the interpretation of graph eigenvalues and eigenvectors, e.g., transient temperature distributions in a graph-like collection of heat-conducting rods.
Nonwettable Thin Films from Hybrid Polymer Brushes can be Hydrophilic(
图书
)
1
edition published
in
2007
in
英语
and held by
1
library
worldwide
Hybrid brushes composed of two liquid polymers, poly(dimethylsiloxane) (PDMS) and a highly branched ethoxylated polyethylenimine (EPEI), were synthesized on Si wafers by the "grafting to" method and by applying a combinatorial approach (fabrication of gradient brushes). The combinatorial approach revealed a strong effect of "layer assisted tethering", which allowed us to synthesize hybrid brushes twice as thick as the reference homopolymer brushes. The hybrid brushes are stable thin films that can rapidly and reversibly switch between hydrophilic and hydrophobic states in water and air, respectively. The switching in water affects a rapid release of amino functional groups which can be used to regulate adhesion and reactivity of the material. The switching in air rapidly returns the brush to a hydrophobic state. The hybrid brush is hydrophilic because of two mechanisms: (1) exposure of EPEI chains to the brush-water interface under water, and (2) retention of some fraction of water via swollen EPEI chains (the EPEI chains swell by 2-3 times), which are conserved by a PDMS cap in air. The hybrid brush is wettable under water, and at the same time, the brush is nonwettable in air because water droplets are trapped in a metastable state when the water contact angle is above 9O%.
Experiments With a Self-Adaptive Multigrid Barotropic Tropical Cyclone Track Model(
图书
)
1
edition published
in
1999
in
英语
and held by
1
library
worldwide
Accurate prediction of hurricane tracks may require resolving the flow both within and around the storm. Since the spatial scales in these two regions differ substantially, uniform resolution is inherently inefficient: the grid should be refined only near the storm. This paper describes the performance of a barotropic model with an adaptive multi-grid scheme which automatically refines the mesh around the storm as it moves. The model is formulatedl on a section of the sphere using a Mercator projection. The model consists of a modified barotropic vorticity equation.
Studies in Nonlinear Optics. Recent Accomplishments(
图书
)
1
edition published
in
1996
in
英语
and held by
1
library
worldwide
This report describes recent publications of Prof. Kaup and associates. The research areas covered include nonlinear optics solitions in optical fibers, dual-core fibers, and applications of the variational method to the above.
Effects of Specimen Size and Geometry Effects, Loading Rate and Microstructure on the Tensile Fracture of Saline Ice(
图书
)
1
edition published
in
1995
in
英语
and held by
1
library
worldwide
This report contains the details of the experimental program on large-scale in-situ arctic sea ice tests. A total of six field trips were completed. The experiments conducted included flexure tests, fracture tests as well as tests where the ice specimen was subjected to cyclic and creep-recovery type loading. A maximum size range ratio of 1 to 160 was accomplished in fracture tests specifically to study the effect of variation in size. About six different geometries, (3 point bend, cantilever beam, griffith crack geometry, reverse taper geometry, square plate geometry, and rectangular plate geometry) were utilized to study the effect of geometry on tensile fracture. Since the field trips occurred in three seasons, seasonal variations in ice properties including sea ice thickness variation were studied. The ice types were S1 freshwater ice, S2 freshwater ice, S2 sea ice, thin lead ice and multiyear sea ice.
Applied Numerical Methods with Coifman-Meyer Bases(
图书
)
1
edition published
in
1995
in
英语
and held by
1
library
worldwide
The main mathematical ideas behind this project was to implement Ciofman-Meyer type bases in various numerical algorithms. In Particular, when large grid FFT are concerned, the refining of grids near discontinuity is impractical and lead to very expensive CPU overhead. The CF bases allow the imposition of the bells such that the discontinuous domains can be stitched together. In microprocess simulations it is critical and discontinuities appear naturally. The finite numerical apperture of the optical systems presents a discontinuity in k-space, and the implementation of the bells with the CF bases provided the necessary mathematical mechanism for the algorithms construction. (AN).
Manufacturing & Optimization Problems of Electromagnetic Devices(
图书
)
1
edition published
in
1996
in
英语
and held by
1
library
worldwide
During the duration of this project, we have developed several new algorithms for simulation of microstructures, devices, and fabrication methods for IC technology. We have interacted extensively with both industrial and government labs and collaborated with personnel of both. We have developed algorithms for imaging of microstructures, investigated the effects of off-axis illumination and finite-thickness effects on mask imaging. Furthermore, we have investigated the effects of post-exposure baking on chemically amplified resists, optimized stepper parameters, as well as proximity effects on mask making. Last, but not least, we developed new visualization algorithms that allow multiple viewing of the microchip processes.
Reliability of Multilayer Copper/Polyimide(
图书
)
1
edition published
in
1993
in
英语
and held by
1
library
worldwide
The reliability of copper/polyimide (PI) multilayer structures was analyzed and found to depend on processing and environmental conditions. Copper films were deposited by thermal evaporation and patterned by contact lithography. Preimidized P12590-D polyimide films were spin coated over the copper with upper layers deposited as required. While the electrical characteristics of the multilayer structures generally behaved as expected, the softening of the underlying PI films led to observation of film buckling and dielectric breakdown in some samples. Consequently, alternate low temperature plasma and laser techniques for depositing copper on PI films, instead of PI films on copper, were explored to improve the reliability of the resulting Cu/PI multilayer structures. Copper films were deposited on PI substrates by radio frequency (13.56 MHz) plasma-induced reduction and excimer laser-induced ablation of copper formate. While the Cu/PI interface appears clean, the reduction of the formate was not complete with some residual carbon contamination in the copper film. Several methods for improving the purity of the Cu films were investigated. Diamondlike carbon (DLC) films are excellent barriers for the diffusion of Cu in Cu/Si structures. DLC films, due to their excellent compatibility with PI, may play a similar useful role in Cu/PI structures and improve their reliability. Copper/polyimide(PI), Diamondlike carbon(DLC) films, Cu/PI Multilayer structures.
A Mathematical Model for River Ice Processes(
图书
)
1
edition published
in
1993
in
英语
and held by
1
library
worldwide
River ice processes are complex phenomena that are affected by many factors, including meteorological conditions, thermal inputs, hydraulic conditions and channel geometry. In this study a one-dimensional model called RICE is developed for simulating ice processes in rivers. In the river hydraulics component, the flow condition is determined by an implicit finite- difference solution of one-dimensional unsteady flow equations. In the thermal component, distributions of water temperature and ice concentration are determined by a Lagrangian-Eulerian solution scheme for equations of transport of thermal energy and ice. A two-layer formulation is introduced to model the ice transport. In this formulation the total ice discharge is considered to consist of the surface ice discharge and the discharge of suspended ice distributed over the depth of the flow. The effect of surface ice on ice production, as well as the formation of skim ice and border ice, is included. The dynamic formation and stability of the ice cover is formulated according to existing equilibrium ice jam theories with due consideration to the interaction between the ice cover and the flow. The undercover ice accumulation is formulated according to the critical velocity criterion. The growth and decay of the ice cover is simulated using a finite-difference formulation applicable to composite ice covers consisting of snow, ice and frazil layers. The model has been applied to the St. Lawrence River and the Ohio River system, with simulated results comparing favorably with field observations. Future improvements on the mathematical model as well as theoretical formulations on various ice processes are discussed.
Mechanism of Intermittent Atomization(
图书
)
1
edition published
in
1993
in
英语
and held by
1
library
worldwide
A theory is developed for the purpose of enhancing the efficiency of internal combustion engines, and to reduce the air pollution caused by inefficient combustion. The theoretical results show that the droplet formation from the leading edge of the liquid fuel jet is caused by th Taylor-Lamb instability during the decerelation phase of the intermittent spray. The mechanism of droplet formation from the rest of the liquid-gas interface is caused by the interfacial stress fluctuation. The decerelation of the liquid jet tends to reduce the droplet diameter at the same pressure. However, finer sprays can be produced with a more sudden reduction in the nozzle inlet pressure after its peak during the injection period. An increase in the compressibility of the liquid jet is shown the promote the generation of smaller droplets, although at a slower rate. The compressibility of the ambient gas, as well as the surface tension, tends to promote absolute instability. The precise physical meaning remains unclear. The absolute instability can be reduced to convective instability by reducing the surface tension and/or increasing the compressibility of the jet fluid. The convective instability is responsible for the formation of sprays ... Intermittent fuel sprays, Atomization.
Colloid and Interface Chemistry Aspects of Ceramics(
图书
)
1
edition published
in
1993
in
英语
and held by
1
library
worldwide
The major goal of this project was to address the properties and interactions of fine powders of interest in ceramics. In order to arrive at quantitative conclusions and assure reproducibility of data, the first requirement was to have well defined dispersions consisting of uniform particles of different chemical compositions (simple or mixed) and in different shapes. Thus, one part of the program has dealt with the synthesis of such 'monodispersed' powders. Specifically, we have produced colloidal particles of different metals, metal oxides, and silicon nitride. In addition, internally mixed particles of stoichiometrically defined metal ratios (such as metal niobates) and of variable composition have been obtained. Finally, coated particles of inorganic cores covered with shells of either different inorganic compounds or of polymers were prepared. All these systems were characterized in terms of their bulk and surface properties. In the other part of the program, we studied, theoretically and experimentally, interactions between unlike particles (i.e., the stability of mixed dispersions), in order to evaluate compaction and sintering effects of such powders. The rate of heterocoagulation was followed in aqueous dispersion of different combinations of particles and the obtained data were compared with expected values based on different theoretical models. The significant discrepancies between the experimentally evaluated and calculated stability ratios could be reconciled, if the surface charge segregation was taken into account. Adhesion of particles, Ceramic powders, Coated particles, Colloid particles, Composite particles, Heterocoagulation, Monodispersed colloids, Powders.
Mechanism of Atomization and Behavior of Non-Dilute Sprays(
图书
)
1
edition published
in
1992
in
英语
and held by
1
library
worldwide
By use of the ARO equipment grant and the Clarkson matching fund, the existing one channel Aerometric Phase Doppler Particle Analyzer is upgraded to a two channel system with a Fourier Spectral Analyzer. The prices of the components of the system are listed in Appendix A. This system is integrated into a complete system for the experimental investigation of intermittent sprays. The complete system is depicted in Fig. 1 in Appendix B. The system is used to measure the distributions of velocity and size of droplets formed in stationary as well as intermittent sprays of Diesel fuel and other test liquids. Preliminary results of the measurement are given.
Nonlinear Modulational Stability and Propagation of an Electromagnetic Pulse in a Two-Component, Neutral Plasma(
图书
)
1
edition published
in
1989
in
英语
and held by
1
library
worldwide
Nonlinear effects are studied including possible modulational instability of an intense electromagnetic pulse propagating through a fully- ionized, unmagnetized plasma. The envelope is shown to evolve over long time scales in general according to a vector form of the well-known cubic nonlinear Schroedinger (NLS) equation. Three distinct nonlinear effects contribute terms cubic in the amplitude and thus can be of comparable magnitude: ponderomotive forces, relativistic corrections, and harmonic generation. Influence of an ambient magnetic field on the nonlinear modulational stability of circularly polarized electromagnetic pulses in a two-component, neutral plasma; the nonlinear modulational stability properties of plasma electromagnetic pulses are extended to include the presence of an ambient magnetic field Bo parallel to the direction of propagation. The positive component may consist of either positrons or singularly charged ions, and on specific assumptions or approximations are made concerning the mass ratio of the components. Approximate solutions are derived which describe the evolution of a circularly polarized pulse. The envelope is shown to evolve over long time scales according to the cubic nonlinear Schroedinger (NLS) equation. (JHD).
Fundamental Mechanism of Atomization(
图书
)
1
edition published
in
1989
in
英语
and held by
1
library
worldwide
The physical mechanism of atomization is investigated. A problem statement is given in Section 1. The research has resulted in 6 papers. They are given in the Appendices. The results of the research are summarized in Section 2. The list of publications and the personnel involved in the research are given respectively in Section 3 and 4. The relevant bibliographies on the subject are listed in the references section of each journal article. Keywords: Atomization; Jet; Fuel spray; Jet fuels. (JES).
Elastic and Inelastic Scattering of Colloidal Particles(
图书
)
1
edition published
in
1988
in
英语
and held by
1
library
worldwide
This project has continued the experimental and theoretical investigation of surface enhanced Raman scattering of molecules adsorbed on silver colloids. It includes the combined enhancement of normal and resonance Raman scattering as well as the observation of each of these effect separately on the same substrate. In addition there were studies of chromate, molybdate and tungstate on colloidal silver. Theoretical studies included the effect on enhancement of adsorption within cavities rather than on convex roughenings, the enhancement of light emission from tunnel junctions and the comparison of SERS calculations with calculation of surface-averaged electromagnetic intensities. In addition, the effect of variation of values of the optical constants on the values of SERS was studied. Keywords: Light scattering, Raman scattering, Surface enhanced Raman scattering, Colloidal silver. (JES).
Aspects of Integrability in One and Several Dimensions(
图书
)
1
edition published
in
1986
in
英语
and held by
1
library
worldwide
The results on Inverse Scattering in multidimensions and on the algebraic properties of equations in 2+1 (i.e. two spatial and one temporal) dimensions should be of particular interest: With respect to algebraic properties of equations in 2+1, the question of finding the recursion operator and the bi-Hamiltonian formulation of these equations has remained open for a rather long time. It was even doubted in the literature if the relevant results in 1+1 could be extended to 2+1. It was recently shown that equations in 2+1 solvable via the Inverse Scattering Transform are bi-Hamiltonian systems. Also given are the recursion and bi-Hamiltonian operators for large classes of equations in 2+1, including the Kadomtsev-Petviashvili (a two dimensional analogue of the Korteweg-deVries) and the Davey-Stewartson (a two dimensional analogue of the nonlinear Schrodinger) equations.
Nonlinear Analysis and Optimal Design of Dynamic Mechanical Systems for Spacecraft Application(
图书
)
1
edition published
in
1987
in
英语
and held by
1
library
worldwide
This research developed analysis and optimal designed procedures for planar as well as spatial mechanisms that are frequently used in space structures. A nonlinear finite element procedure developed originally for planar mechanisms during the initial stages of this research, has been modified considerably to handle complex mechanisms with sliding masses and mechanisms operating at relatively high speeds. The analysis takes into account the effects of geometric mand material nonlinearities, vibrational effects and coupling of deformations. Numerical results have been reported for certain mechanism examples. The effects of nonlinearities have been found to be significant on the dynamic behavior of mechanisms. Considerable progress has been made in developing a nonlinear finite element procedure for three-dimensional mechanisms. Numerical results obtained for some example problems indicate the validity of the current three-dimensional formulation. A new optimization algorithm has also been developed based on the Gauss method to handle various types of nonlinear constraints with the goal of reducing the number of analyses required to obtain an optimal design. Complete details of the nonlinear finite element procedures as well as the optimization technique are available in published papers, copies of which are included here in the Appendix. Because of the complex nature of the nonlinear analysis, which had to be repeated many times during the optimization process, considerable amount of computer was needed for this research.
Energy Deposition in Gallium Arsenide(
图书
)
1
edition published
in
1985
in
英语
and held by
1
library
worldwide
This report pertains to the single-event-upset phenomena in microelectronic circuits with emphasis on those resulting from nuclear reactions induced by energetic protons. Our goal is to understand the detailed physical mechanisms leading to SEUs sufficiently to put calculating SEUs on a sound quantitative basis. We previously had considerable success in predicting the charge generation in well defined slabs of silicon. The purpose of this contract was to try extending the model and the associated simulation codes to GaAs and to begin the experimental measurements necessary to test them. The Clarkson Nuclear Reaction models were modified to handle proton-induced nuclear reactions in gallium arsenide. The codes were immediately useful in analyzing the significance that the edge-effect phenomena, discovered in microbeam studies of GaAs gates, would play in increasing the SEU rates for GaAs memories. Techniques were developed using these codes for calculating SEU rates for select circuits flown in space (9). Two of these circuits, the 2901B and the 93L422 are responsible for SEU problems aboard US satellites. Charge-Collection Measurements have been carriied out using the GaAs Fat-FET test structures from the Rockwell memories.
Power Quality Study for Proposed Integrated Power System(
图书
)
1
edition published
in
2004
in
英语
and held by
1
library
worldwide
The body of this report consists of seven chapters, each of which describes a principal topic of research into shipboard power quality issues. These topics include: Grounding study for bus connected high impedance grounded generators, the potential of a variable frequency, variable voltage generation system for improved efficiency and pulse loading capability, motor starting capability of fixed frequency inverters, the use of wavelet analysis to detect broken rotor bars in induction motors, motor surge characteristics, the use of wavelet analysis to monitor shipboard power system faults, and the investigation of partial discharge in motor windings. This work provides the framework for improvements in the quality and performance of shipboard power systems.
more  fewer 
 Related Identities
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Kaup, D. J.
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Dempsey, John P.
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Lin, S. P.
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Luck, Linda A.
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Tokarev, Ihor
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Fokas, A. S.
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Minko, Sergiy
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McNulty, Peter J.
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Fulton, Scott R.
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Mitchell, Brittany L.
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