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HEBREW UNIV JERUSALEM (Israel)

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Works: 116 works in 138 publications in 1 language and 141 library holdings
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Publications about HEBREW UNIV JERUSALEM (Israel)
Publications by HEBREW UNIV JERUSALEM (Israel)
Most widely held works by HEBREW UNIV JERUSALEM (Israel)
Proteases of Stored Product Insects and their Inhibition by Specific Protease Inhibitors from Soybeans and Wheat Grain ( Book )
5 editions published between 1987 and 1989 in English and held by 7 libraries worldwide
Specific protease inhibitors, which inhibit digestive proteases of insects, have evolved in plants. These inhibitors are of potential interest in protection of valuable crops from damage by insects. It has been the objective of the present study to isolate and characterize digestive proteases of several model insect pests and to investigate their naturally-occurring inhibitors from legume seeds and grains. The separation and partial characterization of trypsin and chymotrypsin-like enzymes from the digestive tracts of the insects Tenebrio molitor, Tribolium castaneum and Locusta migratoria and the inhibitability of these enzymes by proteinaceous trypsin-chymotroypsin inhibitors from soybeans and chick peas suggest that these insects may be affected by the inhibitors in vivo. The lack of disulfide bridges in the insects proteases suggest a difference in their conformation and assembly from that known for the respective mammalian enzymes
Development of Protective Agent Against Sulfur Mustard-Induced Skin Lesions ( file )
4 editions published between 1999 and 2005 in English and held by 4 libraries worldwide
Sulfur mustard(SM) is a potent vesicant employed as a chemical weapon in various conflicts during the 20th century (1,2). It functions as a powerful alkylator and highly cytotoxic blisterogen in both humans and animals (1-9). Skin exposed to SM develops erythema within 30 minutes to several hours after exposure followed by edema, vesicle and blister formation, ulceration, necrosis and desquamation (2,7,8,10). The severity of lesions observed after exposure to SM has emphasized the need for an efficient pharmacological antidote against its vesicating activity. The powerful alkylating activity of SM(11-13) results from its conversion, in aqueous solution, to the highly electrophilic ethylene episulfonium derviative (2) which can be neutralized by nucleophilic agents
Genetic and Epigenetic Mechanisms Underlying Acute and Delayed Neurodegenerative Consequences of Stress and Anticholinesterase Exposure ( file )
4 editions published between 2000 and 2003 in English and held by 4 libraries worldwide
To characterize neuropathological consequences of excess acetyicholinesterase (AChE), we employed transgenic mice developed under previous US Army support. These mice demonstrated association between such excess and adverse responses (in brain and intestine) to pyridostigmine and diisopropylfluorophosphonate. The stress-associated "readthrough" AChE-R variant was seen also in progenitor blood cells, suggesting its use as a surrogate marker for anti-AChE responses. Moreover, AChE-R accumulates in the brain following head injury, its pre-injury excess exacerbates damage, and its antisense suppression improves survival and recovery. Using a 2-hybrid yeast screen we discovered a previously unknown interaction of AChE-R with RACK 1, a protein kinase cargo protein involved in signaling processes. Animals carrying a tetracycline-inducible anti-AChE antisense sequence are being characterized for further studies of these interactions. At the extended promoter of the A CHE gene, we found a 4 bp deletion that over-induces transcription and hypersensitivity to pyridostigmine through impairment of HNF3beta interaction, and discovered a novel mutation that disrupts the glucocorticoid binding site. Finally, we found AChE-R-specific inhibitor interactions in mouse brain that reflect the specific increase in the AChE-R variant after psychological stress., The AChE-R variant thus emerges as the key scavenger and acetylcholine- hydrolzing agent in several mammalian tissues under various stress insults
Transgenic Engineering of Cholinesterases: Tools for Exploring Cholinergic Responses ( file )
3 editions published between 1998 and 1999 in English and held by 3 libraries worldwide
The long-term objective of the research in the laboratory is to understand the molecular and cellular mechanisms that mediate the coupling of short-term changes in cholinergic neurotransmission to long-term consequences in motor, cognitive and autonomous functions. To study the pathways by which cholinergic inputs control neuritic and synaptic cytoarchitecture and determine changes in downstream-regulated genes, we have developed transgenic and antisense models which enable gain- and loss-of-function modulation in several acetylcholinesterase (AChE) variants. These led to the observation that AChE expression is essential for growth and affects synaptic development through its catalytic function, core protein and variable-termini domains. In transgenic mice, we found that overproduction alters expression of the neuronal circuitry-related members of the neurexin gene family and causes late onset, progressive deterioration in dendrite branching, neuromotor and cognitive faculties. Using hippocampal brain slices and an in vivo stress protocol, we demonstrated that both acute stress and exposure to anti-cholinesterases disrupt the blood-brain barrier and promote long-lasting changes in cholinergic gene expression. Currently, cosmid sequencing and genotyping studies are being employed to explore the association of intragenic and neighboring sequences with regulation of the expression of the AChE gene, which is essential for responses to drugs and scavenging of poisons
Sixth International Conference on Composite Interfaces ( Book )
2 editions published in 1996 in English and held by 2 libraries worldwide
The Final Proceedings for Sixth International Conference on Composite Interfaces, 5 May 1996 - 8 May 1996 Molecular interactions at interfaces, Structural Characterization, Theoretical aspects of the interfaces/interphases, interfacial adhesion: theory and applications, surface characterization techniques, surface treatments
Hyperfine interactions in the ground state and first excited state of dy161 in dysprosium iron garnet by R Bauminger( Book )
1 edition published in 1961 in English and held by 2 libraries worldwide
The hyperfine Zeeman splittings in the recoilfree absorption spectrum of the 26 kev gamma ray from Dy-161m in Dy-161 situated in dysprosium iron garnet have been observed. At 85 K, the magnetic hyperfine interactions of the ground state and first excited state of Dy-161 are -400 + or - 40 mc and 455 + or - 40 mc, respectively. The electric quadrupole interactions (eqQ/4) at this temperature are 120 + or - 30 and 90 + or - 30 mc, respectively. At 300 degrees K the effective magnetic field (H sub eff) is 4.6 times smaller, and illustrates the proportionality between H sub eff and spontaneous magnetization of the Dy sub-lattice. Assuming Parks value of -0.37 + or - 0.05 nm for the Dy-161 ground state magnetic moment, H sub eff (85 K) equals 3.5 x 10 to the 6th power oe, and 0.42 + or - 0.08 nm for the magnetic moment of the first excited state were obtained. At 300 K a quadrupole interaction of less than 20 mc was obtained. The strongly temperature dependent quadrupole interaction is interpreted as being largely due to the effective electric field gradient produced at the nucleus by the 4f electrons which should be partially aligned below the Curie temperature. (Author)
RESEARCH IN THE AREA OF MATHEMATICAL ANALYSIS by Shmuel Agmon( Book )
2 editions published between 1961 and 1962 in English and held by 2 libraries worldwide
The investigations of the mathematical analysis research group during the contract year (1960/61) are described
ON SEQUENTIAL LANGUAGES ( Computer File )
2 editions published in 1961 in English and held by 2 libraries worldwide
18TH Annual Meeting of the European Neuroscience Association ( Book )
2 editions published in 1996 in English and held by 2 libraries worldwide
The Final Proceedings for 18th Annual Meeting of the European Neuroscience Association, 3 September 1995 - 7 September 1995. RNA editing alters drug responses to AMPA receptors, Cis-trans regulation of Target genes for neurocognitive drugs, Endogeneous cacabinoid ligands in the central nervous system and in the periphery, Recimbinant acetylcholinesterase as a drug scavenger
Development Novel Subwavelength Light Sources and Lasers ( Book )
2 editions published in 1998 in English and held by 2 libraries worldwide
With the help of the support we have received from the United States Advanced Research Projects Agency through the United States Army our laboratory has pioneered lensless near-field optics. The optical resolution that has been achieved with this novel advance has already carried optics to a new frontier of resolution in the range of tens of nanometers. These studies have indicated that the ultimate resolution that could be achieved with this new direction in optics could even approach the dimension of a single atom or molecule. Thus, the barrier of optical resolution has been broken by the revolution that has occurred as a result of the development of near-field optical imaging. Near-field optics elegantly bridges both exciting fundamental research and a wide variety of practical applications. These applications portend a relatively transparent integration of near-field optical technology with currently available far-field optical techniques to overcome the solid brick wall of resolution that many of these optical applications now experience
RESEARCH ON OPTICS OF SELECTIVE SURFACES ( Book )
2 editions published between 1959 and 1960 in English and held by 2 libraries worldwide
Selective surfaces for solar energy absorbers comprise a metal base, of low intrinsic thermal emissivity modified - usually by the addition of surface coatings to obtain a high absorptivity to solar radiationoion with as little increase as possible to the emissivity. This combination constitutes a reflection filter. The programme concerned itself primarily with nickel-black coatings produced by electro-deposition. It was shown that the chemical and optical properties of these coatings varies with thickness and with the conditions in the placing bath. New optical and mathematical techniques were developed to determine the optical constants of thin absorbing layers (which are not necessarily isotropic in depth) and how to manipulate them to produce filters with desired characteristics. Early selective surfaces of this kind used a pair of different nickel-black layers on a metal base and passable filter properties were obtained. Development of the theory of these surfaces suggested the addition of an intermediate layer (metallic) to produce a three-layer system with a very broad interference region in the solar spectrum. Some work was started on other 'blacks' such as chromium-black. (Author)
Energy Transfer between Inorganic Ions in Glasses ( Book )
2 editions published between 1974 and 1975 in English and held by 2 libraries worldwide
Absorption and fluorescence spectra of Er(3+) in germanate and tellurite glasses were obtained. Spontaneous transition probabilities were calculated using the Judd-Ofelt theory and intensity parameters obtained from measured integrated absorption coefficients. Quantum efficiencies of the fluorescences were measured by the comparative method and by the use of measured decay times. Multiphonon relaxation rates were calculated using the experimental data. Radiative transition probabilities from energy levels of Tm(3+) in glasses were calculated using the matrix elements obtained by intermediate coupling schemes and experimentally obtained intensity parameters. Nonradiative transition probabilities in different glass hosts were calculated. Quantum efficiencies of luminescence of rare earth in glasses can be predicted. Absorption and Fluorescence spectra of Sm(3+) were measured in GeO2, ternary germanate and borax glasses. From these the intensity parameters were calculated by use of Judd-Ofelt formula. Visible emission and decay times of Sm(3+) and its relative quantum efficiencies were measured
SOLID STATE CHEMICAL REACTIONS (WITH SPECIAL REFERENCE TO THE KINETICS OF THE REACTION OF INORGANIC OXIDANTS WITH POLY-DIVINYLBENZENE) ( Book )
2 editions published in 1961 in English and held by 2 libraries worldwide
The heterogeneous reaction in the solid phase of various high melting organic substances with solid oxidants in the presence of catalysts was investigated. The oxidants were KClO4, KBrO3, KNO3, KClO3, KIO3, chloranil and SeO2. The substrates were polycyclic aromatic compounds and polymers, in particular a co-polymer of p-divinylbenzene and p-ethylstyrene. A large number of high-melting substances, including inorganic salts, oxides, and metal powders were tried as catalysts. Generally, Lewis acids (Al2(SO4)3, FeCl2, etc.) catalyzed the reaction, while basic substances (Na2CO3, LiOH, etc.) inhibited it. The empirical equation dx/dt = k (a-x)/x to the 2nd power/3 fitted the kinetic curves for the catalyzed KClO4, KIO3 and KBrO3 oxidations of pDVB; and the zero order equation dx/dt = k fitted the kinetic data for the catalyzed KClO3 oxidation of pDVB. (Author)
Studies on the Molecular Dissection of Human Cholinesterase Variants and their Genomic Origins ( file )
2 editions published between 1995 and 1996 in English and held by 2 libraries worldwide
To evaluate the capacity of overexpressed recombinant human cholinesterases or mutated variants thereof to confer protection against anti-cholinesterase toxicity, we employed transiently transgenic Xenopus laevis tadpoles and stably transgenic mice. Normal and mutant variants of butyrylcholinesterase (BuChE) revealed partially overlapping binding sites for several inhibitors and demonstrated the involvement of the oxyanion hole in BuChE catalysis. In the developing tadpoles the isoform of AChE, which terminates with the 3'-exon 6, was efficiently accumulated in neuromuscular junctions and conferred resistance to the organophosphate paraoxon. In transgenic mice, exon 6-terminated AChE, under control of its authentic promoter, accumulated in CNS synapses and conferred resistance to paraoxon and several cholinergic agonists, but caused progressive deterioration in both neuromotor and cognitive functioning. Finally, in a human patient carrying the "atypical'1 (D7OG) gene for BuChE, we observed adverse responses to prophylactic doses of the carbamate pyridostigmine and from this and in vitro studies predicted a generalized genetic predisposition to anti- cholinesterase therapies, including that approved for the treatment of Alzheimer's disease
Molecular Biological Studies on the Biogenesis of Human Cholinesterases In Vivo and as Directed by Cloned Cholinesterase DNA Sequences ( file )
2 editions published between 1989 and 1990 in English and held by 2 libraries worldwide
Acetylcholinesterase (ACHE) is an enzyme long noted for its essential role in the termination of neurotransmission at cholinergic synapses and neuromuscular junctions. Because acetylcholinesterase is the target protein for a variety of neurotoxic compounds, including natural poisons, common agricultural insecticides, and chemical warfare agents, research on this enzyme in man has profound implications for human health and well-being. Together with the related but distinct protein butyrylcholinesterase (BCHE), it presents an intriguing model for the basic scientific study of tissue-specific and differential regulation of gene expression employing divergent pathways in protein biosynthesis
Approximated Planes in Parallel Coordinates ( Book )
1 edition published in 2000 in English and held by 1 library worldwide
For the visualization of multivariate problems, a multidimensional system of Parallel coordinates is used which provides a one-to-one mapping between subsets of N-space and subsets of 2-space. A rigorous methodology for doing and seeing N-dimensional geometry emerges as well as several applications. Here an application to Error Tolerancing involving the visualization and characterization of 'approximate coplanarity' is presented. The exact description of the neighborhood of an N-dimensional hyperplane in a parallel coordinate system is given
The effect of rapid change in thermal environment on ability of human blood to acetylate aromatic amines and to incorporate acetate-1-c14 into lipids ( Book )
1 edition published in 1967 in English and held by 1 library worldwide
Exposure of normal subjects to heat (37C) or cold (4-6C) resulted in changes in the incorporation of acetate-1-C14 into the blood lipids in vitro. Exposure to heat resulted in decreased incorporation and the converse occurred on exposure to cold. No significant difference was found in the responses of a small series of heat acclimated subjects on exposure to heat or cold as compared to paired non-acclimated subjects. However, there was a higher initial incorporation in 4 out of 5 heat acclimated subjects as compared to their non-acclimated controls. Addition of epinerphrine or norepinephrine to whole blood in vitro decreased incorporation of acetate-1-C14 into lipids, while addition of insulin increased incorporation. Addition of triiodothyronine had no consistent effect. Insulin stimulated incorporation of acetate into lipids in blood of diabetic subjects to a lesser extent than in the blood of normal subjects. Removal of plasma resulted in increased incorporation of acetate into lipids. The stimulatory effect of insulin on incorporation was also inhibited by the presence of plasma. (Author)
Studies of the internal fields acting on nuclei in ferromagnetic and paramagnetic solids, using recoil-free resonance, absorption (mossbauer effect) ( Book )
1 edition published in 1962 in English and held by 1 library worldwide
Recoil-free gamma ray absorption spectra have been observed in ferromagnetic and paramagnetic solids containing nuclei of Fe57 and Dy161, using radioactive sources of Co57 and Tb161. The hyperfine Zeeman splittings in ferromagnetic materials permit a determination of the effective magnetic field at the nuclei. The effective magnetic field, H, at Fe57 nuclei in yttrium iron garnet, dysprosium iron garnet and in some spinel ferrites have been measured at 300K and 85K. Measurements on Fe3O4 confirm Verwey's hypothesis of a fast exchange between ferrous and ferric ions in the octahedral sites above the transition temperature. H at Dy161 in dysprosium iron garnet has been found to be 3,500,000 oe at 85K and 750,000 oe at 300K and is proportional to the Dy sub-lattice spontaneous magnetization. A large temperature dependent quadrupole interaction in DIG has been observed, which is ascribed to an effective electric field gradient at the Dy nuclei produced by the partially aligned orbitals of the 4f electrons, and thus correlated with the spontaneous magnetization. (Author)
Measures of syntactic complexity by Yehoshua Bar-Hillel( Book )
1 edition published in 1963 in English and held by 1 library worldwide
Investigations on the optical spectra of transition elements in single crystals of high symmetry ( Book )
1 edition published in 1964 in English and held by 1 library worldwide
The theoretical and experimental aspects of the optical spectra of the S state ions Mn2+ and Fe3+ in cubic fields were investigated. The optical spectrum and the ground state splitting of V3+ in Al2O3 was studied. The spectrum of Pr3+ in the single crystal of CaWO4 was measured in absorption and fluorescence. The line shape of the Pr3+ lines was investigated as a function of the temperature. (Author)
 
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