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HEBREW UNIV JERUSALEM (Israel)

Overview
Works: 117 works in 138 publications in 1 language and 141 library holdings
Classifications: QA3, 515.724
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Publications about HEBREW UNIV JERUSALEM (Israel)
Publications by HEBREW UNIV JERUSALEM (Israel)
Most widely held works by HEBREW UNIV JERUSALEM (Israel)
Proteases of Stored Product Insects and their Inhibition by Specific Protease Inhibitors from Soybeans and Wheat Grain ( Book )
5 editions published between 1987 and 1989 in English and held by 7 libraries worldwide
The research covered by the first Interim Report primarily was devoted to detection, isolation and characterization of digestive proteinases of the rust red flour beetle (Tribolium castaneum), the mealworm (Tenebrio molitor), and the locust (Locusta migratoria). Recently, the latter has been posing a serious threat to valuable crops in different parts of the world. The detection of trypsin- and chymotrypsin-like enzymes in the midgut of Tribolium castaneum larvae suggests that this insect may be susceptible to inhibition by naturally-occuring trypsin- and chymotrypsin-inhibitors. The findings that trypsin and chymotrypsin from the digestive tract of Tenebrio adults differ in amino acid composition from the respective larval enzymes indicates that the composition and consequently, the structure of the proteolytic enzymes in the adult do not remain the same as in the larva after metamorphosis
Development of Protective Agent Against Sulfur Mustard-Induced Skin Lesions ( file )
4 editions published between 1999 and 2005 in English and held by 4 libraries worldwide
Previous studies demonstrated the protective effect of our novel iodine formulation against SM-induced skin lesions. In order to improve the preparation we investigated the inflammatory processes occurring upon SM exposure and particularly those involve cyclooxygenase activity. To evaluate the role of cyclooxygenas-l and -2 (COX-l, COX-2) in sulfur mustard-induced skin toxicity, we applied the agent to the ears of wildtype (WI) and COX-l- and COX-2-deficient mice. In the latter, ear swelling 24 and 48 h after exposure was significantly reduced by 55% and 30%, respectively, compared to WT These findings were confirmed by histopathological evaluation. The COX-2 inhibitor celecoxib resulted in significant reductions of 27% and 28% in ear swelling at intervals of 40 and 60 min between exposure and treatment, respectively. These findings encouraged us to introduce celecoxib, together with the steroidal anti-inflammatory agent clobetasol, into our iodine preparation. After optimization procedures, the ointment was efficacious 60 min (or less) following exposure. The ability of low iodine concentrations to scavenge reactive oxygen species and to inhibit oxidative burst of activated mouse neutropils might explain the protective mechanism of action of iodine. Previous results have shown that prophylactic injection of H2A histone fragment protected against SM-induced skin lesions. In the present report we found that the T1/2 of the peptide in mouse and humans serum was 7 and 14 min. We also identified the cleavage sites of the peptide by mouse and human serum proteinases; and accordingly synthesized N-methylated analogs for stabilizing the peptide against this proteolytic activity. Injection of the peptide 30 min after exposure significantly reduced ear swelling in the mouse edema model
Genetic and Epigenetic Mechanisms Underlying Acute and Delayed Neurodegenerative Consequences of Stress and Anticholinesterase Exposure ( file )
4 editions published between 2000 and 2003 in English and held by 4 libraries worldwide
To characterize neuropathological consequences of excess acetyicholinesterase (AChE), we employed transgenic mice developed under previous US Army support. These mice demonstrated association between such excess and adverse responses (in brain and intestine) to pyridostigmine and diisopropylfluorophosphonate. The stress-associated "readthrough" AChE-R variant was seen also in progenitor blood cells, suggesting its use as a surrogate marker for anti-AChE responses. Moreover, AChE-R accumulates in the brain following head injury, its pre-injury excess exacerbates damage, and its antisense suppression improves survival and recovery. Using a 2-hybrid yeast screen we discovered a previously unknown interaction of AChE-R with RACK 1, a protein kinase cargo protein involved in signaling processes. Animals carrying a tetracycline-inducible anti-AChE antisense sequence are being characterized for further studies of these interactions. At the extended promoter of the A CHE gene, we found a 4 bp deletion that over-induces transcription and hypersensitivity to pyridostigmine through impairment of HNF3beta interaction, and discovered a novel mutation that disrupts the glucocorticoid binding site. Finally, we found AChE-R-specific inhibitor interactions in mouse brain that reflect the specific increase in the AChE-R variant after psychological stress., The AChE-R variant thus emerges as the key scavenger and acetylcholine- hydrolzing agent in several mammalian tissues under various stress insults
Transgenic Engineering of Cholinesterases: Tools for Exploring Cholinergic Responses ( file )
3 editions published between 1998 and 1999 in English and held by 3 libraries worldwide
The long-term objective of the research in the laboratory is to understand the molecular and cellular mechanisms that mediate the coupling of short-term changes in cholinergic neurotransmission to long-term consequences in motor, cognitive and autonomous functions. To study the pathways by which cholinergic inputs control neuritic and synaptic cytoarchitecture and determine changes in downstream-regulated genes, we have developed transgenic and antisense models which enable gain- and loss-of-function modulation in several acetylcholinesterase (AChE) variants. These led to the observation that AChE expression is essential for growth and affects synaptic development through its catalytic function, core protein and variable-termini domains. In transgenic mice, we found that overproduction alters expression of the neuronal circuitry-related members of the neurexin gene family and causes late onset, progressive deterioration in dendrite branching, neuromotor and cognitive faculties. Using hippocampal brain slices and an in vivo stress protocol, we demonstrated that both acute stress and exposure to anti-cholinesterases disrupt the blood-brain barrier and promote long-lasting changes in cholinergic gene expression. Currently, cosmid sequencing and genotyping studies are being employed to explore the association of intragenic and neighboring sequences with regulation of the expression of the AChE gene, which is essential for responses to drugs and scavenging of poisons
18TH Annual Meeting of the European Neuroscience Association ( Book )
2 editions published in 1996 in English and held by 2 libraries worldwide
The Final Proceedings for 18th Annual Meeting of the European Neuroscience Association, 3 September 1995 - 7 September 1995. RNA editing alters drug responses to AMPA receptors, Cis-trans regulation of Target genes for neurocognitive drugs, Endogeneous cacabinoid ligands in the central nervous system and in the periphery, Recimbinant acetylcholinesterase as a drug scavenger
RESEARCH ON OPTICS OF SELECTIVE SURFACES ( Book )
2 editions published between 1959 and 1960 in English and held by 2 libraries worldwide
The feasibility of improving the performance of solar heat collectors by applying the principles of selective radiation is discussed. Electroplated black nickel deposits gave the best results. The chemical composition, structure, optical properties, mathematical interpretation, AND MODELS OF BLACK NICKEL DEPOSITS WERE INVESTIGATED. The conclusions are summarized
Sixth International Conference on Composite Interfaces ( Book )
2 editions published in 1996 in English and held by 2 libraries worldwide
The Final Proceedings for Sixth International Conference on Composite Interfaces, 5 May 1996 - 8 May 1996 Molecular interactions at interfaces, Structural Characterization, Theoretical aspects of the interfaces/interphases, interfacial adhesion: theory and applications, surface characterization techniques, surface treatments
Hyperfine interactions in the ground state and first excited state of dy161 in dysprosium iron garnet ( Book )
1 edition published in 1961 in English and held by 2 libraries worldwide
The hyperfine Zeeman splittings in the recoilfree absorption spectrum of the 26 kev gamma ray from Dy-161m in Dy-161 situated in dysprosium iron garnet have been observed. At 85 K, the magnetic hyperfine interactions of the ground state and first excited state of Dy-161 are -400 + or - 40 mc and 455 + or - 40 mc, respectively. The electric quadrupole interactions (eqQ/4) at this temperature are 120 + or - 30 and 90 + or - 30 mc, respectively. At 300 degrees K the effective magnetic field (H sub eff) is 4.6 times smaller, and illustrates the proportionality between H sub eff and spontaneous magnetization of the Dy sub-lattice. Assuming Parks value of -0.37 + or - 0.05 nm for the Dy-161 ground state magnetic moment, H sub eff (85 K) equals 3.5 x 10 to the 6th power oe, and 0.42 + or - 0.08 nm for the magnetic moment of the first excited state were obtained. At 300 K a quadrupole interaction of less than 20 mc was obtained. The strongly temperature dependent quadrupole interaction is interpreted as being largely due to the effective electric field gradient produced at the nucleus by the 4f electrons which should be partially aligned below the Curie temperature. (Author)
Energy Transfer between Inorganic Ions in Glasses ( Book )
2 editions published between 1974 and 1975 in English and held by 2 libraries worldwide
;Contents: Optical properties of bismuth in germanate, borax and phosphate glasses; The determination of the nephelauxetic effect in oxide glasses by Sn(2+), Sb(3+), Tl(+), Pb(2+) and Bi(3+) ions; Variation of fluorescence intensities and lifetime of Sm(3+) and Tb(3+) with As2O3 content in arsenic and borax glasses; Multiphonon relaxation of rare earth ions in borate, phosphate, germanate and tellurite glasses; Optical intensities of holmium in tellurite, calibo and phosphate glasses; Quantum yield of Ce(3+) and energy transfer between Ce(3+) and Tb(3+) in borax glasses; Energy transfer between Pb(2+) and Eu(3+) in germanate glass; Energy transfer from Ce(3+) to Tm(3+) in borate and phosphate glasses; Energy transfer between Bi(3+) to Eu(3+), Bi(3+) to Sm(3+) and UO2(2+) yield Eu(3+) in oxide glasses; Properties of rare earth doped inorganic glasses as related to their lasing abilities
Development Novel Subwavelength Light Sources and Lasers ( Book )
2 editions published in 1998 in English and held by 2 libraries worldwide
With the help of the support we have received from the United States Advanced Research Projects Agency through the United States Army our laboratory has pioneered lensless near-field optics. The optical resolution that has been achieved with this novel advance has already carried optics to a new frontier of resolution in the range of tens of nanometers. These studies have indicated that the ultimate resolution that could be achieved with this new direction in optics could even approach the dimension of a single atom or molecule. Thus, the barrier of optical resolution has been broken by the revolution that has occurred as a result of the development of near-field optical imaging. Near-field optics elegantly bridges both exciting fundamental research and a wide variety of practical applications. These applications portend a relatively transparent integration of near-field optical technology with currently available far-field optical techniques to overcome the solid brick wall of resolution that many of these optical applications now experience
Studies on the Molecular Dissection of Human Cholinesterase Variants and their Genomic Origins ( file )
2 editions published between 1995 and 1996 in English and held by 2 libraries worldwide
Research has been focused on the human cholinesterase genes, their variant protein products and the biological roles of these proteins in different tissue - and cell types. To elucidate the biochemical properties and biological functions of this large array of ChE variants, we employed microinjected oocytes and transiently transgenic embryos of Xenopus laevis. This has led to the demonstration that the C-terminal peptide characteristic of the brain and muscle form of acetyicholinesterase (AChE) and butyrylcholinesterase (BuChE) leads to synaptic targeting of these enzymes. Moreover, we were able to show that AChE exerts a morphogenic action on synapse development. The biochemical and biological functions of the BCHE gene and its BuChE protein product were approached by a combination of Xenopus oocyte expression and molecular genetics. Substitution of Asp at position 70 in BuChE by Gly creates an enzyme incapable of hydrolyzing succinylcholine, unlike the native enzyme. This structure-function relationship explained the known clinical syndrome of "succinylcholine apnea". The next step was to replace the BuChE peptide harboring Asp70 with that of AChE. This introduced charge modification in the resultant active chimera and explained many of the differences between AChE and BuChE with respect to drug and poison sensitivities. A population diversity study revealed 11% heterozygotes for Asp/Gly70 among Israelis and shed new light on individual variabilities noted for the newly tested anti-AChE drugs, examined for their potential in Alzheimer's therapy. Our current efforts are to extend these studies to elucidate the protective roles of these proteins against organophosphate intoxication, using transgenic mice overexpressing the human ACHE gene
Solid state chemical reactions (with special reference to the kinetics of the reaction of inorganic wxidants with poly-divinylbenzene) ( Book )
2 editions published in 1961 in English and held by 2 libraries worldwide
The heterogeneous reaction in the solid phase of various high melting organic substances with solid oxidants in the presence of catalysts was investigated. The oxidants were KClO4, KBrO3, KNO3, KClO3, KIO3, chloranil and SeO2. The substrates were polycyclic aromatic compounds and polymers, in particular a co-polymer of p-divinylbenzene and p-ethylstyrene. A large number of high-melting substances, including inorganic salts, oxides, and metal powders were tried as catalysts. Generally, Lewis acids (Al2(SO4)3, FeCl2, etc.) catalyzed the reaction, while basic substances (Na2CO3, LiOH, etc.) inhibited it. The empirical equation dx/dt = k (a-x)/x to the 2nd power/3 fitted the kinetic curves for the catalyzed KClO4, KIO3 and KBrO3 oxidations of pDVB; and the zero order equation dx/dt = k fitted the kinetic data for the catalyzed KClO3 oxidation of pDVB. (Author)
ON SEQUENTIAL LANGUAGES ( Book )
2 editions published in 1961 in English and held by 2 libraries worldwide
Molecular Biological Studies on the Biogenesis of Human Cholinesterases in vivo and as Directed by Cloned Cholinesterase DNA Sequences ( file )
2 editions published between 1989 and 1990 in English and held by 2 libraries worldwide
Acetylcholinesterase (ACHE) is an enzyme long noted for its essential role in the termination of neurotransmission at cholinergic synapses and neuromuscular junctions. Because acetylcholinesterase is the target protein for a variety of neurotoxic compounds, including natural poisons, common agricultural insecticides, and chemical warfare agents, research on this enzyme in man has profound implications for human health and well-being. Together with the related but distinct protein butyrylcholinesterase (BCHE), it presents an intriguing model for the basic scientific study of tissue-specific and differential regulation of gene expression employing divergent pathways in protein biosynthesis
The influence of sentence structure on the reading progress ( Book )
1 edition published in 1966 in English and held by 1 library worldwide
It was assumed that the human user of language incorporates a device which operates along the lines of a generative grammar. Accordingly, experiments were conducted on the psychological reality of the syntactical constituent and the behavioral effects of grammatical transformations and of sentence complexity. Other syntactic variables investigated were sentence length and the relative positions of a pronoun and the noun to which it refers. Methodological problems of readability research are also discussed. (Author)
Studies of the internal fields acting on nuclei in ferromagnetic and paramagnetic solids, using recoil-free resonance, absorption (mossbauer effect) ( Book )
1 edition published in 1962 in English and held by 1 library worldwide
Recoil-free gamma ray absorption spectra have been observed in ferromagnetic and paramagnetic solids containing nuclei of Fe57 and Dy161, using radioactive sources of Co57 and Tb161. The hyperfine Zeeman splittings in ferromagnetic materials permit a determination of the effective magnetic field at the nuclei. The effective magnetic field, H, at Fe57 nuclei in yttrium iron garnet, dysprosium iron garnet and in some spinel ferrites have been measured at 300K and 85K. Measurements on Fe3O4 confirm Verwey's hypothesis of a fast exchange between ferrous and ferric ions in the octahedral sites above the transition temperature. H at Dy161 in dysprosium iron garnet has been found to be 3,500,000 oe at 85K and 750,000 oe at 300K and is proportional to the Dy sub-lattice spontaneous magnetization. A large temperature dependent quadrupole interaction in DIG has been observed, which is ascribed to an effective electric field gradient at the Dy nuclei produced by the partially aligned orbitals of the 4f electrons, and thus correlated with the spontaneous magnetization. (Author)
The effect of rapid change in thermal environment on ability of human blood to acetylate aromatic amines and to incorporate acetate-1-c14 into lipids ( Book )
1 edition published in 1967 in English and held by 1 library worldwide
Exposure of normal subjects to heat (37C) or cold (4-6C) resulted in changes in the incorporation of acetate-1-C14 into the blood lipids in vitro. Exposure to heat resulted in decreased incorporation and the converse occurred on exposure to cold. No significant difference was found in the responses of a small series of heat acclimated subjects on exposure to heat or cold as compared to paired non-acclimated subjects. However, there was a higher initial incorporation in 4 out of 5 heat acclimated subjects as compared to their non-acclimated controls. Addition of epinerphrine or norepinephrine to whole blood in vitro decreased incorporation of acetate-1-C14 into lipids, while addition of insulin increased incorporation. Addition of triiodothyronine had no consistent effect. Insulin stimulated incorporation of acetate into lipids in blood of diabetic subjects to a lesser extent than in the blood of normal subjects. Removal of plasma resulted in increased incorporation of acetate into lipids. The stimulatory effect of insulin on incorporation was also inhibited by the presence of plasma. (Author)
Extension of compact operators by Joram Lindenstrauss( Book )
1 edition published in 1962 in English and held by 1 library worldwide
Investigations on the optical spectra of transition elements in single crystals of high symmetry ( Book )
1 edition published in 1964 in English and held by 1 library worldwide
The theoretical and experimental aspects of the optical spectra of the S state ions Mn2+ and Fe3+ in cubic fields were investigated. The optical spectrum and the ground state splitting of V3+ in Al2O3 was studied. The spectrum of Pr3+ in the single crystal of CaWO4 was measured in absorption and fluorescence. The line shape of the Pr3+ lines was investigated as a function of the temperature. (Author)
Approximated Planes in Parallel Coordinates ( Book )
1 edition published in 2000 in English and held by 1 library worldwide
For the visualization of multivariate problems, a multidimensional system of Parallel coordinates is used which provides a one-to-one mapping between subsets of N-space and subsets of 2-space. A rigorous methodology for doing and seeing N-dimensional geometry emerges as well as several applications. Here an application to Error Tolerancing involving the visualization and characterization of 'approximate coplanarity' is presented. The exact description of the neighborhood of an N-dimensional hyperplane in a parallel coordinate system is given
 
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