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Bucci, Thomas J.

Overview
Works: 6 works in 6 publications in 1 language and 6 library holdings
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Publications about Thomas J Bucci
Publications by Thomas J Bucci
Most widely held works by Thomas J Bucci
Developmental Toxicity (Dominant Lethal Mutation) Study on Agent Lewisite. Dominant Lethal Study of Lewisite in Male Rats ( file )
1 edition published in 1993 in English and held by 1 library worldwide
Lewisite (dichloro(2-chlorovinyl)arsine, Agent L) was investigated as part of the US Army Toxicological Program on Chemical Agents. The study was conducted during January - April, 1990. Dosing was performed during 3-12 January, 1990. Twenty male CD rats per dose group were given 1.5, 0.75 or 0.375 mg/kg Lewisite or vehicle control (one ml sesame seed oil) daily by gavage for 5 days. Positive control males were given one ml sesame seed oil by gavage on Day 1-4 and on Day 5 they were given an intraperitoneal injection of 100 mg/kg ethyl methanesulphonate, a known mutagen. Each male was mated to two virgin females (12 weeks of age) per counted and the uteri and contents were examined. Implantation sites were categorized as live/dead fetuses or early/late resorption. No significant differences inreproductive indices were seen between treatment groups and the control group with the exception of the positive control. Males were killed during Week 13 and necropsied. Sperm morphology/modify, testicular histopathologic evaluation and morphometric analysis of seminiferous tubule cross-sections revealed no differences among Lewisite-treated rats and rats given sesame seed oil. There was no indication of a dominant lethal mutagenic or other toxic effect on the male reproductive tract as a result of exposure to Lewisite, under the conditions of this study. The No Observable Adverse Effect Level was the highest dose used, 1.500 mg/kg
Effects of Altitude on the 'Cebus apella' Monkey ( Book )
1 edition published in 1971 in English and held by 1 library worldwide
Previous studies have shown that abrupt translocation to high altitudes caused a cerebral edema in some humans. In this investigation Cebus apella monkeys were studied at sea level and 14,100 feet altitude to determine what extent cerebral spinal fluid dynamics, cerebral blood flow, and pathological changes of the brain and myocardium play in the pathogenesis of the symptoms of 'acute mountain sickness.' Subhuman primates rapidly transported to 14,110 feet showed increased cerebral blood flow and increased cerebral spinal fluid pressure during the first five days of exposure to high altitude. Significant increases in the right ventricular/total heart weight ratios occurred after 5 days. After 3 months this ratio increased approximately 15% over sea level control values. This change was greater than that found in dogs but less than that in rats or rabbits after prolonged exposure. A mild perivascular cerebral edema occurred in some monkeys at 14,110 feet from 1 to 5 days. Monkey cardiac muscles showed edematous capillary endothelial cells after acute exposure to altitude, while prolonged exposure also caused swollen mitochondria and sarcoplasmic reticula with separation of myofibrils. (Author)
A 90-Day Oral Toxicity Study and a 5-Day Metabolism Study of Diisopropyl Methylphosphonate (DIMP) in Mink ( file )
1 edition published in 1992 in English and held by 1 library worldwide
To reinvestigate the potential toxicity of diisopropyl methylphosphonate (DIMP) in mink (Mustela vison), a 90-day dosed-feed study and a pharmacokinetic/metabolic study in mink and rats were conducted. Eighty 12-13 month-old brown Ranch Wild mink of each sex were randomized by body weight into eight dose groups of ten animals per sex. The animals were caged individually; food consumption and body weight were determined weekly. Blood samples were obtained before treatment began and at weeks 3, 7 and 13. All animals were examined at necropsy and microscopically. The target dose groups were 0, 50, 450, 2700, 5400 and 8000 ppm. The actual concentrations fed were between 97.6 and 133.5% of the target doses. Males and females in the 8000 ppm group consumed 20% and 24% less food than respective controls and overall mean body weight for both sexes was 18% less than the untreated control group. DIMP, Metabolism, Subchronic, Lab animals, MINK, rats
Species Comparison of Cardiac Hypertrophy in Animals Chronically Exposed to High Altitude ( Book )
1 edition published in 1971 in English and held by 1 library worldwide
Heart size and possible causative factors were compared in the dog, rat and rabbit after five months' exposure to sea level, 5,380, 11,140 and 14,110 feet. From 5,380 to 14,110 feet, the ratio of right ventricle to body weight (RV/BW) increased in the rat by 50%, the rabbit by 59% and the dog by 6%. From sea level to 14,110 feet, the ratio of right ventricle to total ventricle (RV/T) increased progressively -- in the rat by 38%, the rabbit by 39% and the dog by 6%. At sea level the dog has a relatively larger right ventricle than either the rat or rabbit, with an RV/T ratio of .26 vs .21 and .22. Similarly, the dog has a RV/BW (g/kg) ratio of 1.66 vs .64 and .35, for the rat and rabbit respectively. Comparing sea level to 14,110 ft., packed cell volume (PCV) increased 16%, 30% and 36% respectively in the dog, rat and rabbit. Mean pulmonary artery pressure increased by 81% in the dog and 87% in the rabbit. These results suggest that hypoxic cardiac hypertrophy is not a simple function of increased PCV and pulmonary artery pressure since these latter changes occurred in all species while hypertrophy did not. The relative size of the heart and its possible reserve potential appear to be important factors. Electron microscopic examination of the myocardium showed markedly enlarged, vesicular pale mitochondria in all three species. The mitochondrial cristae were reduced in number and irregularly arranged. Many of the capillaries had edematous endothelium. The significance of these ultrastructural changes is now known. (Author)
Comparison of Three Rations in Military Scout Dogs Under Moderate Thermal Stress ( file )
1 edition published in 1971 in English and held by 1 library worldwide
To determine whether Standard Item dog foods (dry) would provide sufficient nutrients to permit military working dogs to maintain body weight and work efficiently in warm climates, 3 rations were compared in German Shepherd dogs undergoing Army Scout Dog Training at Ft. Benning, Ga., during July, Aug., and Sept., 1968. The rations were the two Standard Item dry dog foods and a specially-formulated dry ration (MSD). Weight loss occurred in half of the dogs which completed 12 weeks of training. However, as a group, those dogs fed MSD gained weight while those fed the two Standard Item diets lost weight. At least 50 kcal. absorbed per pound of body weight/day were required to prevent weight loss. MSD contains approximately 50% more calories as digestible energy, and each of its macronutrients (protein, fat, carbohydrate, dry matter) was 10-20% more digestible. Thus, not only does MSD contain more calories but its overall digestibility was 94%, compared with 80% for the Standard Item rations. A ration having the palatability and nutrient characteristics of MSD is strongly recommended for military dogs. Moderate to high ambient temperature (75-99F) especially when combined with high relative humidities (95-75%) are poorly tolerated by dogs. In this study, effects ranged from death to milder forms of heat exhaustion. When even slightly overheated, many dogs were inattentive to instruction and were easily distracted. Nearly all dogs consumed less on the hottest days
Cellular Localization of Calcium-Binding Protein ( Book )
1 edition published in 1973 in English and held by 1 library worldwide
The authors have provided histochemical evidence that calcium binding protein (CaBP) is localized in the paracellular and basal region of intestinal cells, thus strengthening the hypothesis that the primary calcium transporting mechanism is localized in this region. The unique previously unreported distributuion of CaBP in renal tubular epithelium will require considerable rearrangement of current concepts of renal calcium metabolism. In fact, the apparent sepcialization of renal tubules may have implications of significance to renal physiology in general, since this degree of renal tubule heterogenicity has not been previously reported. Also, the demonstration of CaBP specific staining in pancreatic islet cells is a completely new finding, the significance and implications of which will only be known through future research
 
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English (6)
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