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Díez, M. José

Overview
Works: 5 works in 5 publications in 1 language and 10 library holdings
Roles: Translator, Author
Publication Timeline
Key
Publications about M. José Díez
Publications by M. José Díez
Most widely held works by M. José Díez
Los lectores del país de las aceitunas by Christine Aziz( Book )
1 edition published in 2007 in Spanish and held by 6 libraries worldwide
Hypoglycemic and hypolipidemic potential of a high fiber diet in healthy versus diabetic rabbits by M. José Diez( Archival Material )
1 edition published in 2013 in Undetermined and held by 1 library worldwide
The aim of this study was to investigate potential hypoglycaemic and hypolipidemic effects of Plantago ovata husk included in the diet, in healthy and diabetic rabbits. We also examined the effects of this fiber in other biochemical parameters. Two groups of 18 rabbits were used.The first group was fed with standard chow and the second with chow supplemented with Plantago ovata husk (3.5mg/kg/day). On day 14 diabetes mellitus was induced by the intravenous administration of alloxan (80mg/kg). After an oral glucose load (3 g), glucose, insulin, and other biochemical parameters were determined on day 14 (healthy rabbits) and on day 28 (diabetic rabbits). In healthy rabbits, fiber did not modify glucose or insulin levels but decreased significantly total cholesterol, LDL-cholesterol, atherogenic index, and glycosylated hemoglobin. In diabetic rabbits, fiber was more beneficial in mild diabetics than in severe diabetics with significant decreases in glucose levels and increases in insulin concentrations. In these animals fiber caused an important reduction in cholesterol, indicating a beneficial effect of Plantago ovata husk in diabetic rabbits. Although further studies in patients are necessary, we think that Plantago ovata husk offers interesting perspectives to be administered to patients with diabetes mellitus
Farmacocinética clínica del Levamisol en el conejo I : Administración oral by M. José Diez( Archival Material )
1 edition published in 1989 in Undetermined and held by 1 library worldwide
En el presente trabajo estudiamos la absorción oral del levamisol en el conejo. Para ello utiliz.amos quince conejos New Zealand blancos y se les administró levamisol a razón de 12,5; 16 y 20 mg/kg. Las concentraciones plasmáticas del levamisol se determinaron por cromatografia líquida de alta eficacia y el tratamiento de los datos experimentales se hizo de acuerdo a un modelo bicompartimental abierto con un proceso de absorción de primer orden. La velocidad del proceso de absorción fue moderada como indican los tiempos en que se alcanzaron las concentraciones máximas: 30 minutos para la dosis de 12,5 mg/ kg y 60 minutos para las dosis de 16 y 20 mg/kg. Asímismo las concentraciolllls má­ ximas observadas fueron 0,68; 1,12 y 1,50 µg/ml respectivamente
Farmacocinética clínica del levamisol en el conejo. II: Administración subcutánea by M. José Diez( Archival Material )
1 edition published in 1989 in Undetermined and held by 1 library worldwide
Para estudiar la absorción del levamisol por vía subcutánea, utilizamos quince conejos New Zealand blancos a los que se les administró levamisol por dicha vía a razón de 12,5; 16 y 20 mg/kg La determinacion de las concentraciones plasmáticas se hizo por cromatografía liquida de alta eficacia y el tratamiento de los datos experimentales se llevó a cabo considerando un modelo bicompartimental abierto con un proceso de absorción de orden 1
The hydrosoluble fiber Plantago ovata husk improves levodopa (with carbidopa) bioavailability after repeated administration by M. José Diez( Archival Material )
1 edition published in 2008 in Undetermined and held by 1 library worldwide
The influence of treatment duration (7 or 14 days) with Plantago ovata husk/levodopa/carbidopa in the bioavailability and other pharmacokinetic parameters of levodopa were evaluated in rabbits. Fiber was administered at two different doses, 100 and 400 mg/kg, and the dosage of levodopa/carbidopa was 20:5 mg/kg. These doses were administered once a day. When 100 mg/kg of fiber was administered, the mean AUC value obtained for levodopa increased 20.2% from day 1 to day 7, and 27.2% from day 1 to day 14; Cmax was 8.6% higher on day 7 and 11.7% higher on day 14. When administering 400 mg/kg of fiber, the increase in AUC values was 17.6% on day 7 and 24.9% on day 14, and that of Cmax 11.1% on day 7 and 11.3% on day 14. The concentration determined immediately before drug administration (Cmin) increased progressively with the duration of treatment, and the highest increase (53.2%) was observed on day 14 with 100 mg/kg of fiber. There was also a delay in levodopa elimination (higher MRT and lower Cl) in a fiber-dose dependent manner. In summary, we found that there was an improvement in the extent of levodopa absorbed with higher final concentrations and that levodopa elimination was slower with the administration of P. ovata husk
 
Languages
Spanish (1)
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