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Mitchell, Douglas

Overview
Works: 50 works in 71 publications in 1 language and 166 library holdings
Genres: Software 
Roles: Author, Arranger
Classifications: T385, 006.6869
Publication Timeline
Key
Publications about Douglas Mitchell
Publications by Douglas Mitchell
Most widely held works by Douglas Mitchell
Adobe Photoshop ( visu )
10 editions published between 1991 and 1997 in English and held by 60 libraries worldwide
Demonstrates the use of Adobe Photoshop art production software on a Macintosh
QuarkXPress ( visu )
5 editions published between 1991 and 1994 in English and held by 16 libraries worldwide
Teaches viewers about QuarkXPress, a desktop publishing program
Clarinet Ensemble Music - PRINZ, A. ( file )
in English and held by 11 libraries worldwide
Macromedia director ( visu )
1 edition published in 1994 in English and held by 10 libraries worldwide
Demonstrates applications of Macromedia Director version 4.0 for Windows and the Macintosh. Shows how to create presentations (simulation, animation, and slide shows) as well as how to create interactivities
QuickTime ( visu )
1 edition published in 1994 in English and held by 7 libraries worldwide
QuickTime is a system extension file of instructions enabling your computer to re-draw videos in a window. Video, sound, artwork, text, and animation can be merged to create a presentation
Executive summary of the Professional Sport Policy Committee by Alberta( Book )
3 editions published in 1995 in English and held by 7 libraries worldwide
MacroMind director ( visu )
3 editions published between 1991 and 1992 in English and held by 5 libraries worldwide
Teaches MacIntosh users how to create multi-media productions by combining animation, graphics, music and sound effects
Synthetic studies towards pyrrolizidine and indolizidine alkaloids by Douglas Mitchell( Book )
3 editions published in 1992 in English and held by 4 libraries worldwide
QuarkXPress ( visu )
1 edition published in 1992 in English and held by 3 libraries worldwide
Covers advanced text techniques, fractions, Pantone color use, separating colors, edition colors, nesting procedures, and prep for linotronic
"Sounding good with other people" by Douglas Mitchell( Article )
1 edition published in 2015 in English and held by 3 libraries worldwide
Macromedia director ( visu )
1 edition published in 1996 in English and held by 3 libraries worldwide
Demonstrates applications of Macromedia Director version 5.0 for Windows and the Macintosh
Photoshop 4.0 : ( visu )
1 edition published in 1997 in English and held by 2 libraries worldwide
Demonstrates the use of Photoshop 4.0 art production software for both MacIntosh and Window users
Macromedia director ( visu )
1 edition published in 1996 in English and held by 2 libraries worldwide
Demonstrates applications of Macromedia Director version 5.0 for Windows and the Macintosh
Evolution and dynamic behavior of transfer RNA in the first two steps of translation by Alexis A Black Pyrkosz( file )
1 edition published in 2010 in English and held by 2 libraries worldwide
In protein synthesis, a key component of the cellular machinery is transfer RNA (tRNA). This small nucleic acid is crucial to the maintenance of the genetic code because it discriminately binds the messenger RNA codon at the ribosome and adds the cognate amino acid to the growing polypeptide chain. The role of tRNA as an adaptor molecule has been understood for decades, but details about the charging of tRNA with cognate amino acids prior to entering the ribosome are still emerging. Aminoacyl-tRNA synthetases (aaRSs) are enzymes that recognize specific tRNAs and amino acids from the cellular pool and facilitate the charging of the correct amino acids on tRNAs. Following aminoacylation, tRNAs dissociate from the aaRSs and bind the elongation factor Tu (EF-Tu) for delivery to the ribosome. The recognition of specific tRNA species by the aaRSs, EF-Tu, and other enzymes along the translation pathway is based on sets of highly conserved nucleotides within different groups of tRNA species. Previous work to identify these recognition elements has focused on experimental studies of single organisms. Here, bioinformatic analyses are used to predict recognition elements for groups of tRNA organized by domain of life and specificity. Shannon entropy differences between evolutionary profiles of tRNA domain/specificity groups and the representatives of all tRNA species reveal the uniquely conserved nucleotides within each tRNA domain/specificity, consistent with experiment. Comparative analysis of consensus sequences for these evolutionary profiles is used to locate tuning elements, also consistent with experiment. The discriminator base and the G53:C63 base pair are identified as conserved in several tRNA domain/specificities, particularly among Archaea. Both sets of predictions expand on the current knowledge of recognition elements, providing suggestions for new mutation studies. AaRS:tRNA complex formation and the aminoacylation reaction have been well-characterized through many high resolution crystal structures and biochemical assays, but dissociation of the charged tRNA with subsequent binding to EF-Tu is not well understood. Using molecular modeling and molecular dynamics simulations, the effects of protonation states and the presence/absence of substrates and EF-Tu on tRNA release are explored. Using multiple dynamics and energetics analyses, the migration of protons from the 3' end of the tRNA and the alpha-ammonium group on the charging amino acid is shown to accelerate tRNA dissociation. The presence of AMP has only a minimal effect. Further, pKa calculations predict that Glu41, a conserved residue binding the alpha-ammonium group of the charging amino acid, is part of a proton relay system for releasing the charging amino acid upon transfer. This system is conserved both in structure and sequences across homologous aaRSs and may represent a universal handle for binding and releasing the charging amino acid. Addition of EF-Tu to the aaRS:tRNA complex stimulates tRNA dissociation. Knowledge of the exit strategies leads to a greater understanding of tRNA dynamics between the first two steps of translation
QuarkXPress ( visu )
1 edition published in 1992 in English and held by 2 libraries worldwide
Projects working with text, paragraph formatting, pictures, and style sheets are shown
Adobe Photoshop CS3 training ( file )
1 edition published in 2007 in English and held by 2 libraries worldwide
Macromedia director ( visu )
1 edition published in 1996 in English and held by 2 libraries worldwide
Demonstrates applications of Macromedia Director version 5.0 for Windows and the Macintosh
Photoshop 4.0 : ( visu )
1 edition published in 1997 in English and held by 2 libraries worldwide
Demonstrates the use of Photoshop 4.0 art production software for both MacIntosh and Window users
Professional Sport Policy Committee interim report : a status of Committee proceedings to date by Alberta( Book )
2 editions published in 1994 in English and held by 2 libraries worldwide
 
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Languages
English (39)
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