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St. John, Steve

Works: 2 works in 2 publications in 1 language and 39 library holdings
Genres: Juvenile works  Poetry 
Roles: Author
Classifications: PS3570.R589, 818
Publication Timeline
Publications about Steve St. John
Publications by Steve St. John
Most widely held works by Steve St. John
Cajun night before Christmas by Trosclair( Sound Recording )
1 edition published in 1992 in English and held by 38 libraries worldwide
Side 1: A version in Cajun dialect of the famous poem "The Night Before Christmas," set in a Louisiana bayou. Side 2: Santa Claus moves his headquarters to the Louisiana bayou and replaces his reindeer with flying alligators
Bacillus anthracis co-opts nitric oxide and host serum albumin for pathogenicity in hypoxic conditions by Steve St. John( Book )
1 edition published in 2013 in English and held by 1 library worldwide
Bacillus anthracis is a dangerous pathogen of humans and many animal species. Its virulence has been mainly attributed to the production of Lethal and Edema toxins as well as the antiphagocytic capsule. Recent data indicate that the nitric oxide (NO) synthase (baNOS) plays an important pathogenic role at the early stage of disease by protecting bacteria from the host reactive species and S-nytrosylating the mitochondrial proteins in macrophages. Another toxin-independent mechanism relevant to late-stage anthrax was shown with non-phagocytic host cells exposed to pathogenic factors secreted by B. anthracis in microaerobic (hypoxic) conditions. In addition to synergistic effect of the pore-forming hemolysin (anthrolysin O) perforating the host cell and the fermentation metabolite (succinic acid) fueling the release of reactive oxygen species from mitochondria, this mechanism involves the activity of NO-derived toxic product(s). In this study we for the first time present evidence that NO produced by baNOS participates in the generation of highly reactive oxidizing species which could be abolished by the NOS inhibitor L-NAME, free thiols, and superoxide dismutase but not catalase. The formation of toxicants is a result of the simultaneous formation of NO and superoxide leading to a labile peroxynitrite and its stable decomposition product, nitrogen dioxide. The toxicity of bacteria could be potentiated in the presence of bovine serum albumin, which serves as a trap of a volatile NO accelerating its reactions. Our data suggest that during infection in the hypoxic environment of pre-mortal host the accumulated NO is expected to have a broad toxic impact on host cell functions
Alternative Names
St. John, Stephan
St. John, Stephen Ames
St. John, Steve
St. John, Steven
English (2)
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