WorldCat Identities

Tsien, Roger Y.

Overview
Works: 15 works in 20 publications in 1 language and 181 library holdings
Genres: Filmed interviews  Interviews  Filmed performances  Conference papers and proceedings 
Roles: Author
Publication Timeline
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Most widely held works about Roger Y Tsien
 
Most widely held works by Roger Y Tsien
Nobel Prize concert 2008 : Dvořák, Mozart( Visual )

1 edition published in 2008 in English and held by 132 WorldCat member libraries worldwide

The Nobel Prize Concert 2008 was a world-class event featuring a marvellous array of performers: Sir John Eliot Gardiner, his legendary Monteverdi Choir with the Eric Ericson Chamber Choir and the Royal Stockholm Philharmonic Orchestra. Thomas von Heljne has a conversation with conductor Sir John Eliot Gardiner and interviews 2008 Nobel Laureates Martin Chalfie, Paul Krugman, Roger Y. Tsien, and Harald zur Hausen
Coincidence detection in the nervous system : molecular and cellular mechanisms, consequence for learning and memory by Human Frontier Science Program( Book )

1 edition published in 1996 in English and held by 25 WorldCat member libraries worldwide

Coincidence detection in the nervous system by Human Frontier Workshop( Book )

1 edition published in 1996 in English and held by 5 WorldCat member libraries worldwide

Heineken Lectures 2002( Book )

2 editions published in 2003 in English and held by 4 WorldCat member libraries worldwide

Designer molecules to spy on cell signal by Roger Y Tsien( Visual )

2 editions published in 1996 in English and held by 3 WorldCat member libraries worldwide

Breeding and building molecules to spy on cells and tumors by Roger Y Tsien( Visual )

2 editions published in 2010 in English and held by 2 WorldCat member libraries worldwide

"To circumvent the limited spatial resolution of fluorescent protein imaging, we are developing genetically encoded tags for electron microscopy (EM). New flavoproteins photo-generate singlet oxygen molecules, enabling genetically-encoded, correlative, light and electron microscopy. For clinical applications, we need synthetic molecules with novel amplifying mechanisms for homing to diseased tissues. Synthetic peptides provide an amplifying mechanism for targeting fluorophores, MRI contrast agents, and drugs to sites of protease activity (e.g. tumors) in vivo. Separately, we have developed fluorescent peptides that light up peripheral nerves to show surgeons where not to cut. Roger Tsien, 2008 Nobel Laureate in Chemistry, University of California (San Diego)."--NIST Technicalendar announcement
The design and use of organic chemical tools in cellular physiology by Roger Y Tsien( Book )

3 editions published in 1976 in English and held by 2 WorldCat member libraries worldwide

Detection of Subclinical Arthritis in Mice by a ThrombinReceptor–Derived Imaging Agent( )

1 edition published in 2017 in English and held by 1 WorldCat member library worldwide

Abstract : Objective: Functional imaging of synovitis could improve both early detection of rheumatoid arthritis (RA) and long‐term outcomes. Given the intersection of inflammation with coagulation protease activation, this study was undertaken to examine coagulation protease activities in arthritic mice with a dual‐fluorescence ratiometric activatable cell‐penetrating peptide (RACPP) that has a linker, norleucine (Nle)‐TPRSFL, with a cleavage site for thrombin. Methods: K/BxN‐transgenic mice with chronic arthritis and mice with day 1 passive serum‐transfer arthritis were imaged invivo for Cy5:Cy7 emission ratiometric fluorescence from proteolytic cleavage and activation of RACPPNleTPRSFL . Joint thickness in mice with serum‐transfer arthritis was measured from days 0 to 10. The cleavage‐evoked release of Cy5‐tagged tissue‐adhesive fragments enabled microscopic correlation with immunohistochemistry for inflammatory markers. Thrombin dependence of ratiometric fluorescence was tested by exvivo application of RACPPNleTPRSFL and argatroban to cryosections obtained from mouse hind paws on day 1 of serum‐transfer arthritis. Results: In chronic arthritis, RACPPNleTPRSFL fluorescence ratios of Cy5:Cy7 emission were significantly higher in diseased swollen ankles of K/BxN‐transgenic mice than in normal mouse ankles. A high ratio of RACPPNleTPRSFL fluorescence in mouse ankles and toes on day 1 of serum‐transfer arthritis correlated with subsequent joint swelling. Foci of high ratiometric fluorescence localized to inflammation, as demarcated by immune reactivity for citrullinated histones, macrophages, mast cells, and neutrophils, in soft tissue on day 1 of serum‐transfer arthritis. Ex vivo application of RACPPNleTPRSFL to cryosections obtained from mice on day 1 of serum‐transfer arthritis produced ratiometric fluorescence that was inhibited by argatroban. Conclusion: RACPPNleTPRSFL activation detects established experimental arthritis, and the detection of inflammation by RACPPNleTPRSFL on day 1 of serum‐transfer arthritis correlates with disease progression
Matrix-Metalloproteinases in Head and Neck Carcinoma–Cancer Genome Atlas Analysis and Fluorescence Imaging in Mice( )

1 edition published in 2014 in English and held by 1 WorldCat member library worldwide

Objective: (1) Obtain matrix-metalloproteinase (MMP) expression profiles for head and neck squamous cell carcinoma (HNSCC) specimens from the Cancer Genomic Atlas (TCGA). (2) Demonstrate HNSCC imaging using MMP-cleavable, fluorescently labeled ratiometric activatable cell-penetrating peptide (RACPP). Study Design: Retrospective human cohort study; prospective animal study. Setting: Translational research laboratory. Subjects and Methods: Patient clinical data and mRNA expression levels of MMP genes were downloaded from TCGA data portal. RACPP provides complementary ratiometric fluorescent contrast (increased Cy5 and decreased Cy7 intensities) when cleaved by MMP2/9. HNSCC–tumor bearing mice were imaged in vivo after RACPP injection. Histology was evaluated by a pathologist blinded to experimental conditions. Zymography confirmed MMP-2/9 activity in xenografts. RACPP was applied to homogenized human HNSCC specimens, and ratiometric fluorescent signal was measured on a microplate reader for ex vivo analysis. Results: Expression of multiple MMPs including MMP2/9 is greater in patient HNSCC tumors than matched control tissue. In patients with human papilloma virus positive (HPV+) tumors, higher MMP2 and MMP14 expression correlates with worse 5-year survival. Orthotopic tongue HNSCC xenografts showed excellent ratiometric fluorescent labeling with MMP2/9-cleavable RACPP (sensitivity = 95.4%, specificity = 95.0%). Fluorescence ratios were greater in areas of higher tumor burden ( P < .03), which is useful for intraoperative margin assessment. Ex vivo, human HNSCC specimens showed greater cleavage of RACPP when compared to control tissue ( P = .009). Conclusions: Human HNSCC tumors show increased mRNA expression of multiple MMPs including MMP2/9. We used RACPP, a ratiometric fluorescence assay of MMP2/9 activity, to show improved occult tumor identification and margin clearance. Ex vivo assays using RACPP in biopsy specimens may identify patients who will benefit from intraoperative RACPP use
Building molecules to spy on synapses and tumors( Visual )

1 edition published in 2007 in English and held by 1 WorldCat member library worldwide

Imaging & manipulating protein interactions & gene expression in individual cells( Visual )

1 edition published in 1999 in English and held by 1 WorldCat member library worldwide

Calcium and membrane depolarization waves in islets of Langerhans in pancreas tissue slices( )

1 edition published in 2013 in English and held by 1 WorldCat member library worldwide

Sculpting molecules for fun and profit( Visual )

1 edition published in 2007 in English and held by 1 WorldCat member library worldwide

 
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WorldCat IdentitiesRelated Identities
Alternative Names
Rodžer Čen

Roger Tsien americký chemik čínského původu

Roger Tsien Amerikaans biochemicus

Roger Tsien amerykański biochemik chińskiego pochodzenia, noblista

Roger Tsien biochimico statunitense

Roger Tsien biochimiste et biophysicien américain

Roger Tsien US-amerikanischer Zellbiologe und Chemienobelpreisträger

Roger Y. Tsien

Roger Y. Tsien American biochemist

Roger Y. Tsien amerikai biokémikus

Roger Yonchien Tsien

Rogerius Yonchien Tsien

Tsien, Roger Y. 1952-2016

Tsien, Roger Yonchien 1952-2016

Роджер Цянь

Роџер Чен

Тсиен, Роджер

רוג'ר טסיין

راجر تسین

راجر سائن

راجر ٹسین

روجر تسيان

रोजर वाइ ट्सिएन

রজার ওয়াই. তিসিয়েন

როჯერ ციენი

로저 첸

ロジャー・Y・チエン

钱永健

钱永健 美國生物化學家

Languages
English (20)