WorldCat Identities

Marrack, Philippa

Overview
Works: 24 works in 36 publications in 2 languages and 104 library holdings
Genres: Educational films  Filmed lectures  Nonfiction films  Conference papers and proceedings  Essays 
Roles: Author, Editor
Classifications: QR181.7, 616.07
Publication Timeline
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Most widely held works by Philippa Marrack
The immune system : friend and foe( Visual )

5 editions published in 1996 in English and No Linguistic content and held by 45 WorldCat member libraries worldwide

Originally broadcast on December 9 and 10, 1996. Describes the means by which infectious agents avoid destruction by the immune system
Terminating the immune response( Book )

3 editions published in 2010 in English and held by 12 WorldCat member libraries worldwide

The T cell and its receptor by P Marrack( )

2 editions published in 1986 in English and held by 4 WorldCat member libraries worldwide

The immune system, friend and foe( Visual )

1 edition published in 1996 in English and held by 4 WorldCat member libraries worldwide

Originally broadcast December 10, 1996. Dr. Kappler discusses the processes that destroy or inactivate potentially autoreactive lymphocytes
The immune system, friend and foe( Visual )

1 edition published in 1996 in English and held by 2 WorldCat member libraries worldwide

Originally broadcast December 10, 1996. Describes the means by which infectious agents avoid destruction by the immune system
Workshop on Tolerance : Mechanisms and Implications by Workshop on Tolerance: Mechanisms and Implications( Book )

2 editions published in 1989 in English and held by 2 WorldCat member libraries worldwide

T-cells and how to keep a good thing going by P Marrack( Visual )

1 edition published in 1998 in English and held by 1 WorldCat member library worldwide

The T cell repertoire( Book )

1 edition published in 1987 in English and held by 1 WorldCat member library worldwide

Immunity : the battle within : [lectures presented at] Nobel Conference XXVIII, October 6 and 7, 1992 by Nobel Conference( Recording )

1 edition published in 1992 in English and held by 1 WorldCat member library worldwide

Antigen recognition properties of semi-invariant T cell receptors by Mary H Young( Book )

1 edition published in 2013 in English and held by 1 WorldCat member library worldwide

Classical alpha beta T cells express diverse T cell antigen receptors (TCR) that recognize a variety of peptides presented by MHC. However, certain classes of T cells express a more restricted TCR that recognizes other types of antigens presented by non-classical MHC molecules. We sought to understand how the Natural Killer T (NKT) cell TCR is able to respond to a variety of lipid antigens with exquisite specificity. We also characterized the TCR of Mucosal-Associated Invariant T (MAIT) cells by mutagenesis. This allowed us to understand the structural requirements for recognition MR1:antigen complexes. Lastly, we undertook analyses to characterize the antigen that is recognized by the MAIT cell TCR. Taken together, these methods allowed us to understand how the semi-invariant TCRs of NKT and MAIT cells recognize their cognate antigens
T cells and how to keep a good thing going by P Marrack( Recording )

1 edition published in 1998 in English and held by 1 WorldCat member library worldwide

T cells and MHC( Visual )

1 edition published in 2005 in English and held by 1 WorldCat member library worldwide

Speaker introduces lecture noting the talk will not be about T cells and MHC
Current opinion in immunology by Frederick W Alt( Book )

1 edition published in 1968 in English and held by 1 WorldCat member library worldwide

100 years after the Nobel Prize to Paul Ehrlich and Elie Metchnikov : the dualism between innate and acquired immuniyy by Steve Kaufman( Recording )

1 edition published in 2008 in English and held by 1 WorldCat member library worldwide

The T cell repertoire in health and disease by P Marrack( Recording )

1 edition published in 1992 in English and held by 1 WorldCat member library worldwide

Reconocimiento del propio organismo por el sistema inmunitario by P Marrack( )

1 edition published in 1993 in Spanish and held by 1 WorldCat member library worldwide

Immunity : the battle within : [lectures presented at] Nobel Conference XXVIII, October 6 and 7, 1992 by Nobel Conference( Visual )

1 edition published in 1992 in English and held by 1 WorldCat member library worldwide

This conference explores the latest medical and scientific knowledge about the body's defense network
Clarification of the role of host DNA as a mediator of vaccine adjuvant activity by Laura Evelyn Noges( Book )

1 edition published in 2015 in English and held by 1 WorldCat member library worldwide

Aluminum salt (alum) adjuvants are widely used in human vaccination because they are safe and effective at generating antibody-mediated protective immunity. Though it is well known that alum induces T helper 2 responses and antigen-specific IgG1 and IgE antibody production in mice, the mechanism by which alum elicits these effects is poorly understood. Recently, others and our group reported that alum immunization results in the release of host DNA, which mediates adjuvant activity by acting as an endogenous immunostimulatory signal. These conclusions were based, in part, on experiments that combined alum vaccines with DNase I enzymes to study loss-of-function scenarios. Curiously, DNase only inhibited CD4 T cell priming and antibody responses to alum; CD8 T cell activation was not affected. As such, further clarification was needed regarding the role of host DNA in alum adjuvant activity. Here I employed a mouse model system and injectable DNase treatments to study the role of host DNA in mediating immune responses to intramuscular alum vaccines. To ensure that my studies pertained solely to the effects of host DNA within alum biology, I performed comprehensive analysis of relevant DNase reagents that had been used for alum studies in previous publications. Unfortunately, my data indicated that commercial DNase reagents are prone to contain impurities and contaminants including digestive proteases. When alum studies were repeated using pure DNase, I found that alum-associated DNA is actually dispensable in the generation of effective cellular and humoral immune responses by alum vaccines. Furthermore, when proteases were co-injected with alum vaccines, the effects on immune responses mimicked those observed following co-injection with impure DNase reagents. In conclusion, we suggest that host DNA is not a major contributor to the adjuvant effect of alum when vaccines are administered to the muscle and that contaminated reagents may have misled interpretations of past experiments involving DNase reagents. This correction of the literature may help improve future studies to elucidate the mechanism of aluminum salts as vaccine adjuvants, an endeavor that remains paramount to understanding why alum vaccines have successfully protected hundreds of millions of people from disease and how they may be improved for future vaccination strategies
The Harvey lectures : delivered under the Auspices of the Harvey Society of New York, 1993-1994( Book )

1 edition published in 1995 in English and held by 1 WorldCat member library worldwide

How the immune system recognizes the body by P Marrack( )

1 edition published in 1993 in English and held by 0 WorldCat member libraries worldwide

 
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Audience level: 0.40 (from 0.17 for The immune ... to 0.96 for The T cell ...)

The Harvey lectures : delivered under the Auspices of the Harvey Society of New York, 1993-1994
Alternative Names
Marrack, Philippa

Philippa Marrack Amerikaans biologe

Philippa Marrack Biochimiste et immunologue américaine

Philippa Marrack britisch-US-amerikanische Biochemikerin und Immunologin

פיליפה מאראק

菲莉帕·馬拉克

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