WorldCat Identities

Bertozzi, Carolyn R. 1966-

Works: 19 works in 34 publications in 1 language and 295 library holdings
Genres: Conference papers and proceedings 
Roles: Editor, Author, Thesis advisor
Publication Timeline
Most widely held works by Carolyn R Bertozzi
Glycochemistry : principles, synthesis, and applications( Book )

10 editions published in 2001 in English and held by 232 WorldCat member libraries worldwide

Essentials of glycobiology by Ajit Varki( )

1 edition published in 2009 in English and held by 35 WorldCat member libraries worldwide

Glycobiology has its roots in the nineteenth century, when chemists first began to analyze sugar and polysaccharides. Advances in this area continued at a steady rate during most of this century, but the past 20 years has witnessed an unparalleled explosion of new knowledge that has transformed the field. This monograph contains the basic information needed to understand the field of glycobiology along with the most current work at the forefront of the field
The design, construction and calibration of a photoacoustic calorimeter : a research progress paper by Carolyn R Bertozzi( Book )

1 edition published in 1988 in English and held by 4 WorldCat member libraries worldwide

Synthesis and biological activity of carbon-linked glycosides Carolyn Ruth Bertozzi by Carolyn R Bertozzi( )

2 editions published in 1993 in English and held by 4 WorldCat member libraries worldwide

Finding living cells with organic synthesis by Carolyn R Bertozzi( Visual )

2 editions published in 1998 in English and held by 3 WorldCat member libraries worldwide

New therapeutic targets in human and microbial sulfation pathways by Carolyn R Bertozzi( Visual )

2 editions published in 2003 in English and held by 3 WorldCat member libraries worldwide

N‐Carboxyanhydride Polymerization of Glycopolypeptides That Activate Antigen‐Presenting Cells through Dectin‐1 and Dectin‐2( )

2 editions published in 2018 in English and held by 2 WorldCat member libraries worldwide

Abstract: The C‐type lectins dectin‐1 and dectin‐2 contribute to innate immunity against microbial pathogens by recognizing their foreign glycan structures. These receptors are promising targets for vaccine development and cancer immunotherapy. However, currently available agonists are heterogeneous glycoconjugates and polysaccharides from natural sources. Herein, we designed and synthesized the first chemically defined ligands for dectin‐1 and dectin‐2. They comprised glycopolypeptides bearing mono‐, di‐, and trisaccharides and were built through polymerization of glycosylated N ‐carboxyanhydrides. Through this approach, we achieved glycopolypeptides with high molecular weights and low dispersities. We identified structures that elicit a pro‐inflammatory response through dectin‐1 or dectin‐2 in antigen‐presenting cells. With their native proteinaceous backbones and natural glycosidic linkages, these agonists are attractive for translational applications. Abstract : Causing a response : The first chemically defined ligands for dectin‐1 and dectin‐2 were designed and synthesized. These consisted of glycopolypeptides built through the polymerization of glycosylated N ‐carboxyanhydrides. Structures that elicit a proinflammatory response through dectin‐1 or dectin‐2 in antigen‐presenting cells were identified
Metabolic Engineering of Reactive Cell Surfaces for Controlled Cell Adhesion( Book )

2 editions published in 2001 in English and held by 2 WorldCat member libraries worldwide

The objective is to develop techniques for cell surface modification in order to interface cells with synthetic materials in the context of cell-based biosensors. Our approach uses the cell's metabolic machinery for oligosaccharide biosynthesis to deliver novel chemically reactive functional groups to the cell surface. We developed methods for cell adhesion using ketone-hydrazone condensation reactions and a new reaction we developed called the Staudinger ligation. We identified new metabolic pathways for delivery of reactive functional groups to cell surfaces. These tools were used to attach cells to synthetic surfaces in a robust manner with high resistance to shear stress
Chemistry and biology on the surfaces of cells by Carolyn R Bertozzi( Visual )

1 edition published in 2001 in English and held by 2 WorldCat member libraries worldwide

Prof. Carolyn Bertozzi, Departments of Chemistry and Molecular and Cell Biology, and Howard Hughes Medical Institute, University of California at Berkeley. The cell surface is a richly-functionalized landscape that encodes the information a cell communicates to its local environment. We have developed chemical techniques that allow the molecular engineering of cell surfaces for various biomedical applications. Applications of these to tumor diagnostics and genetic selections are discussed
Non-Invasive Imaging of In Vivo Breast Cancer Tissue Utilizing Metabolically Incorporated Unnatural Sugars( Book )

2 editions published in 2004 in English and held by 2 WorldCat member libraries worldwide

Cancer cells have long been known to express glycosylation patterns that are different from those found on normal cells from the same tissue. Many tumor-specific carbohydrate antigens possess the monosaccharide sialic acid, and as a consequence, many tumor cells express high levels of sialic acid compared to normal cells. Thus, any agent that targets sialic acid specifically could be used for tumor targeting. Preliminary work on this project has shown that unnatural sialic acids can be introduced onto tumor cells metabolically by feeding the cells unnatural analogs of their biosynthetic precursors. The unnatural analogs can include reactive functional groups capable of covalent reaction with exogenous probes. For example, an azide-functionalized analog of Nacetylmannosamine is converted by tumor cells to the corresponding sialic acid, and the azide can be covalently reacted on the cell surface with triarylphosphine probes in vivo. The objective of this project is to develop a novel breast cancer targeting method that exploits the selective chemical reactivity of unnatural sialic acids for delivery of imaging reagents. The immediate application is a new method for non-invasive detection and diagnosis of cancer. Longer-term applications include targeted anti-cancer drugs and vaccines
Chemical approaches to the study of N-glycanase 1 : understanding NGLY1 deficiency and implications in cancer therapy by Frederick M Tomlin( )

1 edition published in 2018 in English and held by 1 WorldCat member library worldwide

N-Glycanase 1 (NGLY1) is the human cytosolic protein N-glycosidase. The relationship between NGLY1 and the transcription factor Nrf1 is examined, particularly observing cellular response to proteasomal stress in healthy, NGLY1 deficient, and cancer model systems using genetic and chemical tools. Additionally, the role of NGLY1 in innate immunological signaling and other stress-response pathways that are regulated by the ERAD pathway is explored. Finally, the further development of the Quadricyclane (QC) ligation, a bioorthogonal reaction between QC and nickel bis(dithiolene) is described
Chemistry in living systems : new tools for probing the glycome( Visual )

1 edition published in 2005 in English and held by 1 WorldCat member library worldwide

The power of differentiation : characterizing the regulatory roles of an O-glycosyltransferase and N-glycanase during neural induction of human pluripotent stem cells by Ian William Blong( )

1 edition published in 2018 in English and held by 1 WorldCat member library worldwide

The human body contains over 10 trillion cells spanning hundreds of morphologically distinct cell types. These cells derive from a small subset of pluripotent stem cells (hPSC) that have the ability to propagate indefinitely and can be induced to differentiate into all the cell types of the human body. While the molecular mechanisms that govern the self-renewal and differentiation of these special cells is still being characterized, their ability to uncover complex biological processes, not possible in classic cell culture or animal models, is already being realized. Understanding the biological process that are not encoded in the genome, but exist in other forms of cellular regulation such as post-translational modifications, are essential for advancements in biology and medicine. Glycobiology is the study of the structure, biosynthesis, and processing of sugars and their functional roles in biology. The addition of a single monosaccharide, #xF0E2;-N- acetylglucosamine (O-GlcNAc), to the hydroxy side chain of serine or threonine residues of intracellular proteins has profound implications in cellular homeostasis and disease progression. This post-translational modification shares many similar qualities with phosphorylation but only has two enzymes involved in the addition and removal of O-GlcNAc, making genetic perturbation of its enzymes difficult, when not lethal. O-GlcNAc transferase and O-GlcNAcase, respectively, have been shown to target key transcriptional and epigenetic regulators necessary for stem cell biology. The modification is required for cell viability and perturbations to the regulation of O-GlcNAc have been associated with multiple diseases and disorders. A great deal of interest is currently devoted towards deciphering the functional role of O-GlcNAc in stem cell maintenance and development. Similarly, the deficiency in the NGLY1 enzyme responsible for removing glycans (branched sugars) from misfolded proteins has recently been shown to cause a devastating congenital neurological disorder. Inability to reproduce a pathologically relevant animal model has caused researchers to look toward reprogramming patient cells, into induced pluripotent stem cells (hiPSC), for more accurate modeling of the disorder. In both cases, pluripotent stem cells are being utilized to elucidate molecular mechanisms essential in glycobiology. Chapter 1 briefly covers the history of the field of stem cell biology and major events that defined the field. These events laid the groundwork for revolutionary breakthroughs in research and medicine. How stem cell biology can facilitate advancements in basic and translational research pertaining to glycobiology will be discussed. Moreover, how stem cell biology can advance our understanding of the functional significance of glycobiology. Chapter 2 describes the chemical inhibition of the O-GlcNAc transferase enzyme in understanding O-GlcNAcylation's regulatory role during the neural induction of hPSCs. Inhibition of OGT induced the early expression of neuronal proteins and accelerated the conversion of hESCs into neural stem cells, suggesting a regulatory role of O-GlcNAc in maintaining proper brain development. The results presented in this chapter will also help define the molecular behavior of stem cells during neuronal development so that they can be used effectively and reliably for the treatment of neurodegenerative disorders. Finally, in Chapter 3 describes a new congenital disorder of glycosylation called NGLY1-CDDG. Induction of corrected and uncorrected NGLY1-CDDG hiPSCs towards the neural crest lineage revealed altered morphology and differential gene expression during differentiation. This finding has major implications on future research into modeling the disorder and its potential therapeutic intervention
Cell surface engineering by a modified staudinger reaction by Eliana Saxon( )

1 edition published in 2000 in English and held by 0 WorldCat member libraries worldwide

Chemical glycobiology by Carolyn R Bertozzi( )

1 edition published in 2001 in English and held by 0 WorldCat member libraries worldwide

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Audience level: 0.66 (from 0.62 for Essentials ... to 1.00 for Chemical g ...)

Glycochemistry : principles, synthesis, and applications
Alternative Names
Bertozzi, Carolyn R. 1966-

Bertozzi, Carolyn Ruth 1966-

Carolyn Bertozzi

Carolyn Bertozzi US-amerikanische Biochemikerin

Carolyn R. Bertozzi Amerikaans scheikundige

Carolyn R. Bertozzi amerikansk kemiker

Carolyn R. Bertozzi amerikansk kemist

Carolyn R. Bertozzi amerikansk kjemikar

Carolyn R. Bertozzi amerikansk kjemiker

Carolyn R. Bertozzi chimico statunitense

Carolyn R. Bertozzi chimiste américain

Carolyn R. Bertozzi química estadounidense

Carolyn R. Bertozzi química estatunidenca

Carolyn Ruth Bertozzi química estadounidense

Бертоцци, Каролин

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English (34)