WorldCat Identities

Kéri, György 1950-

Overview
Works: 6 works in 15 publications in 2 languages and 191 library holdings
Genres: Patents 
Roles: Author, Performer, Editor
Publication Timeline
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Most widely held works by György Kéri
Molecular pathomechanisms and new trends in drug research by György Kéri( Book )

8 editions published between 2002 and 2003 in English and held by 183 WorldCat member libraries worldwide

"Molecular Pathomechanisms and New Trends in Drug Research presents an in-depth review of the molecular mechanisms involved in a number of common diseases and disease processes including cancer, AIDS, inflammation, cardiovascular disease and neurodegenerative disorders amongst others, with particular emphasis on signal transduction and potential therapeutic strategies. It will be a useful reference text for students and researchers in chemistry, biochemistry, medicine and the pharmaceutical sciences."--BOOK JACKET
A dudás legendája by György Kéri( Book )

3 editions published in 2002 in Hungarian and held by 4 WorldCat member libraries worldwide

Polyunsaturated fatty acyl-peptide composition( Book )

1 edition published in 1994 in English and held by 1 WorldCat member library worldwide

Development of a 3D Tissue Culture-Based High-Content Screening Platform That Uses Phenotypic Profiling to Discriminate Selective Inhibitors of Receptor Tyrosine Kinases( )

in English and held by 1 WorldCat member library worldwide

3D tissue cultures provide a more physiologically relevant context for the screening of compounds, compared with 2D cell cultures. Cells cultured in 3D hydrogels also show complex phenotypes, increasing the scope for phenotypic profiling. Here we describe a high-content screening platform that uses invasive human prostate cancer cells cultured in 3D in standard 384-well assay plates to study the activity of potential therapeutic small molecules and antibody biologics. Image analysis tools were developed to process 3D image data to measure over 800 phenotypic parameters. Multiparametric analysis was used to evaluate the effect of compounds on tissue morphology. We applied this screening platform to measure the activity and selectivity of inhibitors of the c-Met and epidermal growth factor (EGF) receptor (EGFR) tyrosine kinases in 3D cultured prostate carcinoma cells. c-Met and EGFR activity was quantified based on the phenotypic profiles induced by their respective ligands, hepatocyte growth factor and EGF. The screening method was applied to a novel collection of 80 putative inhibitors of c-Met and EGFR. Compounds were identified that induced phenotypic profiles indicative of selective inhibition of c-Met, EGFR, or bispecific inhibition of both targets. In conclusion, we describe a fully scalable high-content screening platform that uses phenotypic profiling to discriminate selective and nonselective (off-target) inhibitors in a physiologically relevant 3D cell culture setting
Hajnali lovaglás, Falklandi vihar by György Kéri( Recording )

in Hungarian and held by 1 WorldCat member library worldwide

 
Audience Level
0
Audience Level
1
  Kids General Special  
Audience level: 0.58 (from 0.51 for Hajnali lo ... to 0.99 for A fejlett ...)

Molecular pathomechanisms and new trends in drug research
Covers
Alternative Names
György Kéri

György Kéri Hongaars biochemicus

György Kéri Hungarian biochemist

Languages