WorldCat Identities

Seeman, Nadrian C. 1945-

Works: 70 works in 109 publications in 2 languages and 983 library holdings
Genres: Conference papers and proceedings  Academic theses 
Roles: Author, Editor, Honoree
Publication Timeline
Most widely held works about Nadrian C Seeman
Most widely held works by Nadrian C Seeman
DNA computing : 7th International Workshop on DNA-Based Computers, DNA 7, Tampa, FL, USA, June 10-13, 2001 : revised papers by Nataša Jonoska( )

24 editions published between 2002 and 2006 in English and Swedish and held by 582 WorldCat member libraries worldwide

Experimental tools : An object oriented simulation of real accurring molecular biological processes for DNA computing and its experimental verification / T. Hinze, U. Hatnik / - DNAsequenceGenerator : a program for the construction of DNA sequences / U. Feldkamp / - DNA computing in microreactors / D. Van Noort / - Theoretical tools : Coding properties of DNA languages / S. Hussini / - Boundary components of thickened graphs / N. Jonoska / - Probabilistic computational models : Population computation and majority inference in test tube / Y. Sakakibara / - PNA-mediated whiplash PCR / J.A. Rose / - Computer simulation and sequence design : Biomolecular computation in virtual test tubes / M.H. Garzon / - The fidelity of the tag-antitag system / J.A. Rose, R.J. Deaton / - Algorithms : Solving knapsack problems in a sticker based model / M.J. Pérez-Jiménez / - A proposal of DNA computing on beads with application to SAT problems / T. Yoichi / - Experimental solutions : Aqueous solutions of
Structural DNA nanotechnology by Nadrian C Seeman( Book )

9 editions published between 2015 and 2016 in English and held by 183 WorldCat member libraries worldwide

Written by the founder of the field, this is the first text of its kind, providing a definitive introduction to structural DNA nanotechnology. Readers will learn everything there is to know about the subject from the unique perspective of the leading expert in the field. Topics covered range from origins and history, to design, experimental techniques, DNA nanomechanics devices, computing, and the uses of DNA nanotechnology in organising other materials. Clearly written, and benefiting from over 200 full colour illustrations, readers will find this an accessible and easy to follow text that is essential reading for anyone who wants to enter this rapidly growing field. Ideal for advanced undergraduate and graduate students, as well as researchers in a range of disciplines including nanotechnology, materials science, physics, biology, chemistry, computational science and engineering. The first authored book on the topic, written by the founder of the field ; Comprehensive and accessible, including over two hundred colour illustrations ; Interdisciplinary appeal across physical sciences, life sciences, and engineering.--Publisher website
DNA, not merely the secret of life : part 1 of 2 by Nadrian C Seeman( Visual )

1 edition published in 2016 in English and held by 36 WorldCat member libraries worldwide

DNA, not merely the secret of life : part 2 of 2 by Nadrian C Seeman( Visual )

1 edition published in 2016 in English and held by 36 WorldCat member libraries worldwide

Mining smartness from nature : selected, peer reviewed papers from the symposium H "Mining smartness from nature" of CIMTEC 2012-4th international conference "Smart materials, structures and systems", held in Montecatini Terme, Italy, June 10-14, 2012 by P Vincenzini( Book )

3 editions published in 2013 in English and held by 19 WorldCat member libraries worldwide

The 12 peer-reviewed papers collected here together offer a plenitude of up-to-date information on "Mining Smartness from Nature". The papers are conveniently arranged into: Chapter 1: Biomimetic Materials, Chapter 2: Biomimetic Sensors, Actuators and Systems, Chapter 3: Biomimetic Flow Control
Nanotechnology : science and computation by Junghuei Chen( Book )

2 editions published between 2010 and 2011 in English and held by 4 WorldCat member libraries worldwide

Nanoscale science and computing is concerned with the architectures and design of molecular self-assembly, nanostructures and molecular devices, and with understanding and exploiting the computational processes of biomolecules in nature. This book provides an authoritative survey on the research in nanoscale science, engineering and computing
Emergence of function in molecular assemblies by Rigoberto Gaitán-Hernández( Book )

1 edition published in 2008 in English and held by 4 WorldCat member libraries worldwide

Towards potent gene silencing tools: Peptidomimetic transfection agents for siRNA delivery by Yeliz Utku( )

1 edition published in 2009 in English and held by 4 WorldCat member libraries worldwide

RNA interference (RNAi) techniques hold forth great promise for therapeutic silencing of deleterious genes. However, clinical applications of RNAi require the development of safe and efficient methods for intracellular delivery of small interfering RNA (siRNA) oligonucleotides specific to targeted genes. We describe the use of a lipitoid, a cationic oligopeptoid-phospholipid conjugate, for non-viral transfection of synthetic siRNA oligos in cell culture. This peptidomimetic delivery vehicle allows for efficient siRNA transfection in a variety of human cell lines with negligible toxicity and promotes extensive downregulation of the targeted genes at both the protein and the mRNA level. We compare the lipitoid reagent to a standard commercial transfection reagent. The lipitoid is highly efficient even in primary IMR-90 human lung fibroblasts in which other commercial reagents are typically ineffective. Electron microscopy imaging data reveals that lipitoid molecules interact with siRNA oligonucleotides to form well-defined, spherical complexes in the nanometer range. The morphology of these complexes is shown to be dependent on various physiological parameters, which can be readily controlled in the lipitoid-siRNA delivery system. We associate the physical properties to the biological activity of the complexes, concluding that the charge ratio and size of the complexes are of critical importance to attain RNAi effects. These findings are critical to the development of well-controlled, efficient delivery systems. Due to the tunable nature of the peptidomimetic region, this system can be further elaborated to display ligands for the targeting of the complexes to specific tissues
Protein driven DNA nanomechanical devices by Wanqiu Shen( )

1 edition published in 2004 in English and held by 3 WorldCat member libraries worldwide

In Chapter 2, a DNA nanomechanical device has been developed by linking two DNA TX motifs by a shaft of conventional double helical DNA that connects their top domains. This shaft contains the binding site for integration host factor, IHF. When IHF binds to its site on the DNA shaft, it bends it markedly. This bending is monitored by fluorescence resonance energy transfer. We have added a second double helical portion to the bottom domains. This second double helix is nicked near its central region on both strands, creating a 'sticky end'. By relocating the nicks, we are able to estimate the amount of free energy available to do work when IHF binds to the device. We find that the available free energy is about 7 kcal/mol
DNA nanotechnology in biology and chemistry by Shiping Liao( )

1 edition published in 2005 in English and held by 3 WorldCat member libraries worldwide

We developed a DNA nanomechanical device that enables the positional synthesis of products whose sequences are determined by the state of the device. This machine emulates the translational capabilities of the ribosome. The device has been prototyped to make specific DNA sequences. The state of the device is established by the addition of DNA set strands. There is no transcriptional relationship between the set strands and the product strands. The device has potential applications that include designer polymer synthesis, encryption of information, and use as a variable-input device for DNA-based computation
Diagnostics using DNA nanotechnology: Detection of single nucleotide polymorphisms by Harikrishnan K Subramanian( )

1 edition published in 2010 in English and held by 3 WorldCat member libraries worldwide

Single Nucleotide Polymorphisms (SNPs) are the most common genetic variation in the human genome. A variety of methods exist for their detection exploiting the free-energy advantage of Watson-Crick paired nucleotides over mispairs, or they involve the use of enzymes that extend a primer to include the site of interest, resulting in a species with identifiable characteristics. Kinetic methods based on branch migration have proved successful for detecting SNPs because a mispair will inhibit the progress of branch migration in the direction of the mispair. Biased single-stranded branch migration is used prominently for changing the shapes of DNA nanomachines, because it involves the isothermal removal of strands from a DNA machine frame, enabling a change in topology. The unidirectional character of strand removal is based on the notion of a 'toehold', wherein one end of a strand to be removed is extended a few nucleotides beyond its pairing partner; when the full complement of the strand (including the toehold) is added to solution, it pairs with the toehold and then removes the strand by single-stranded branch migration in the direction away from the toehold. Here, we have combined the effectiveness of this approach with atomic force microscopy (AFM) of DNA origami patterns to produce a direct visual readout of the target nucleotide contained in the probe sequence. The origami contains graphical representations of the four possible nucleotide alphabetic characters, A, T, G and C, and the symbol containing the test nucleotide identity vanishes in the presence of the probe. Computer processing of a statistically significant group of images produces a direct symbolic readout that directly identifies the nucleotide carried by the probe
Structural DNA nanotechnology design and self-assembly of two-dimensional and three-dimensional crystalline lattices by Tong Wang( )

1 edition published in 2007 in English and held by 3 WorldCat member libraries worldwide

The deepest challenge in structural DNA nanotechnology is to extend the system of self-assembly from 2D to 3D. A number of designs have been tried to obtain 3D crystalline lattices (crystals): TX in three different systems, 6HB, and 9HB. Double cohesion is used for construction of 3D lattices from 6HB and 9HB. Crystals from 9HB diffract X-rays to 10 A. The unit cell dimensions obtained from X-ray diffraction are not consistent with my design except for the long axis. Nevertheless, the results of 9HB confirm the formation of partially ordered 3D crystalline lattices
DNA Bending by Stephanie Geggier( )

1 edition published in 2011 in English and held by 3 WorldCat member libraries worldwide

The temperature dependence of a was determined by two methods. The first approach was based on measuring the j-factors of short DNA fragments at various temperatures. The second approach was based on measuring the equilibrium distribution of the linking number between the strands of circular DNA at different temperatures. The computation-based analysis of the measured variances was used to obtain the values of a for temperatures up to 60 ºC. We found a good agreement between the results obtained by these two methods. Our data show that DNA persistence length strongly depends on temperature and accounting for this dependence is important in quantitative comparison between experimental results obtained at different temperatures
Flexibility of DNA double crossover molecules and construction of DNA graphs by Phiset Sa-Ardyen( )

1 edition published in 2003 in English and held by 3 WorldCat member libraries worldwide

The feasibility of the molecular computational approach based on the self-assembly of branched DNA junction molecules has been demonstrated by experimentally constructing a DNA graph. The DNA graph chosen for construction corresponds to a prototype system for solving the 3-colorability problem. We used a k-armed branched DNA molecule to represent a vertex of degree k, and a double helical DNA molecule to represent an edge. We also incorporated four restriction sites in each long edge of the graph by means of an extra hairpin fused on to the edge via a three-armed junction. Restricting these sites serves to linearize the graph in a specific way without altering the logical part of the graph. The first step involved self-assembly of component strands to form the vertex and edge building blocks. Then self-assembly of these constructs was allowed to form the graphs, which were subsequently converted to a covalently closed single stranded circle by ligation. Finally the ligated DNA graphs were purified and characterized. By using restriction mapping technique, we are able to prove that the DNA graphs obtained were in correct arrangement
Analysis of DNA Structure in Nucleosomes by Nahum Shiffeldrim( )

1 edition published in 2011 in English and held by 3 WorldCat member libraries worldwide

The DNA of eukaryotic organisms is packaged into a macromolecular structure, called chromatin. The basic repeating element of chromatin is the nucleosome. Nucleosome positioning along chromosomal DNA is significant in many biological processes such as transcription, replication, DNA repair, and gene regulation. It is well established that nucleosome affinity to DNA is sequence-dependent. Thus, many research endeavors focus on DNA sequence and physical properties in relation to nucleosome affinity. Nucleosome affinity and positioning on DNA differ in vivo and in vitro. In the cell, factors such as DNA binding proteins, chromatin modelers, transcription factors and histone modifying enzymes are at play and contribute to nucleosome binding affinity. However, in vitro, the sequence-dependent nucleosome positioning on DNA is governed by the binding free-energy. Paramount to computation of the sequence-dependent free-energy of DNA deformation is the nucleosomal geometric structure on which a DNA fragment is threaded on. We term this geometric structure - nucleosomal 'target structure'. The choices of target structure and elastic parameters specify the sequence-dependence of the computed affinity
Nanotechnology of Nucleic Acids: Beyond Watson-Crick B-DNA Duplexes by Tanashaya Ciengshin( )

1 edition published in 2010 in English and held by 3 WorldCat member libraries worldwide

We have successfully generated new motifs, and nanostructures that introduce a greater variety of nucleic acids and new direction in intra-molecular interactions. The first motif is called the Switchback (SB) DNA motif whose half-turn of DNA is a unit-tangle in which the Watson-Crick helix axes are perpendicular to the main left-handed helical axis of the molecule. The 5-unit-tangle SB molecules have been prepared, however; an attempt to create a self-complementary 4-unit-tangle SB DNA led to a large aggregate of Paranemic Crossover (PX) molecules in 1D array arrangement. We have created SB DNA-RNA hybrid and RNA molecules and proved that they rearrange into 1D array by Fe-EDTA foot-printing, Circular Dichroism spectroscopy, Atomic Force Microscopy in comparison with DNA origami, and Polyacrylamide Gel Electrophoresis
Structural DNA nanotechnology-RNA used to control a DNA rotary nanomachine & DNA origami arrays by Hong Zhong( )

1 edition published in 2007 in English and held by 3 WorldCat member libraries worldwide

Second, photonics is the science and technology to manipulate photons. Since DNA devices can be incorporated into DNA arrays and still function well (Ding et al. 2006), it is possible to assemble DNA molecules into DNA 'chips' to work as the 'hardware' of, for example, photonic computer, which is believed to be much faster than the conventional electric computer. Because the wavelength of visible light in water solution is approximately 285 & sim;560 nm, it is necessary to first build a DNA array serving as platform with around 100 nm spacing, which is roughly the half wavelength of visible light. If the spacing is too small, diffraction happens, which will make the manipulation of visible light impossible. DNA origami is selected as the building block to make the array. One tile and two tile systems are designed. From one tile system, we can construct well-ordered 2D arrays (500nm_500nm) and 1D arrays, which can reach several microns in length. For the two-tile system, only a few tiles can be assembled together correctly. Several different designs are explored, but the well-defined area of the 2D array still cannot reach the order of micron
Structural DNA nanotechnology : studies of two dimensional lattices and crystallization of a DNA decamer by Lisa B Israel-Dreilinger( )

1 edition published in 2006 in English and held by 3 WorldCat member libraries worldwide

One of the goals of structural DNA nanotechnology is to create larger more rigid structures that can be used as building blocks for two-dimensional arrays. Two-dimensional DNA crystals have been designed and constructed from Holliday junction analogues that have been combined in groups of four to form parallelogram-like structures. Two new two-dimensional parallelogram lattices were designed and formed each consisting of four eight-turn helices. In one of the designs called the 4+4 x 4+4 parallelogram there were four turns on the inside and the outside of the parallelogram tile. In the other design, 6+2 x 6+2, there were six turns on the inside and two turns on the outside of the tile. Another larger parallelogram tile has also been created consisting of four twelve turn helices. In order to create a more rigid parallelogram tile double crossover molecules were incorporated into this structure to reinforce each of the helices and to provide double the connection points at the sticky ends, called the DX (double cross-over) parallelogram. Each of the above described two-dimensional parallelogram arrays had the expected periodicity when imaged on the AFM
Structural DNA nanotechnology studies of two and three dimensional lattices by Pamela E Constantinou( )

1 edition published in 2005 in English and held by 3 WorldCat member libraries worldwide

One of the key aims of structural nanotechnology is to design and construct robust structures. Dozens of these constructs have been made successfully using DNA. With applications to gene therapy, it is worth constructing some of them with RNA. The Switchback motif is a molecule that, made with a certain number of tangles, can self-assemble into large aggregates. These aggregates may have purposes in gene therapy if they can be made to target unwanted cells in biological systems
Honeycombs, devices and two-dimensional 2D DNA arrays by Baoquan Ding( )

1 edition published in 2006 in English and held by 3 WorldCat member libraries worldwide

The success of nanorobotics requires the placement of specific nanomechanical devices in particular locations and then having them be functional in that context. The structural programmability of DNA makes it a particularly attractive system for nanorobotics. Sequence-dependent DNA devices that can take advantage of the addressability of DNA molecules had been built previously, but until now, they have just been shape-shifting molecular systems. I have developed a cassette structure that incorporates such a device into a two-dimensional DNA array. I have used atomic force microscopy to demonstrate that this device is functional after being incorporated. This system is likely to lead to large numbers of variable-pattern systems in structural DNA nanotechnology
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DNA computing : 7th International Workshop on DNA-Based Computers, DNA 7, Tampa, FL, USA, June 10-13, 2001 : revised papers
Nanotechnology : science and computation
Alternative Names
Nadrian Seeman

Nadrian Seeman Amerikaans biochemicus

Nadrian Seeman amerikansk nanoteknolog

Nadrian Seeman US-amerikanischer Biochemiker

Nadrijan Siman

Seeman, Nadrian, 1945-

Seeman, Ned, 1945-

Надријан Симан

Симэн, Надриан