WorldCat Identities

Mootha, Vamsi

Overview
Works: 2 works in 2 publications in 1 language and 2 library holdings
Roles: Author
Publication Timeline
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Most widely held works by Vamsi Mootha
Genome-scale maps, measures, and models of mitochondrial function by Vamsi Mootha( Visual )

1 edition published in 2006 in English and held by 1 WorldCat member library worldwide

THE MITOCHONDRIAL PROTEOME AND HUMAN DISEASE( )

1 edition published in 2015 in English and held by 1 WorldCat member library worldwide

Abstract : Mitochondria are ancient organelles found in virtually all of our body's organs. Owing to their bacterial ancestry, they still retain a tiny genome (mtDNA), encoding 13 proteins, while virtually all of the remaining coding capacity has been relegated to the nuclear genome. In this talk, I will present our work over the past decade aimed at systematically characterising all of the nuclear encoded proteins that reside within this organelle. By combining biochemistry, computation, mass spectrometry, and imaging, we have been able to systematically characterise the over 1000+ proteins that comprise human mitochondria. This inventory is now proving to be very useful in the discovery of genes that underlie Mendelian mitochondrial disorders, and for linking common GWAS hits back to the organelle. Moreover, with the advent of next generation sequencing, this inventory is serving as a guide in both the discovery and interpretation of genome sequences for diagnostics. Our work is helping to establish a genomic nosology for mitochondrial disease
 
Audience Level
0
Audience Level
1
  Kids General Special  
Audience level: 0.92 (from 0.88 for THE MITOCH ... to 0.96 for Genome-sca ...)

Alternative Names
Vamsi Mootha Indian biologist

فمسي موثا

వంశీ మూతా

Languages