WorldCat Identities

Tye, Kay M.

Overview
Works: 4 works in 4 publications in 1 language and 18 library holdings
Genres: Academic theses 
Roles: Author
Publication Timeline
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Most widely held works by Kay M Tye
Amygdala processing of the formation and retrieval of cue-reward associations by Kay M Tye( )

1 edition published in 2008 in English and held by 16 WorldCat member libraries worldwide

This thesis examines the neural changes that contribute to the formation, storage, retrieval and extinction of a learned association between a stimulus and a reward. A number of questions were answered in this thesis to provide insight upon the neural substrates of several goal-directed behaviors: What neural changes mediate the initial formation of an associative memory between a stimulus and a reward? What are the synaptic changes that correspond to the development of a change in task-relevant neuronal firing? What is the mechanism of these synaptic changes, and do they have a causal relationship? How are complex emotions such as frustration represented in the brain? How are reward-associated cues endowed with the power to guide goal-directed behaviors in the absence of primary rewards? Here I show that behavior improves with the rapid recruitment of amygdala neurons to the ensemble encoding a reward-predictive cue, and that this change is mediated by the rapid strengthening of thalamic synapses onto amygdala neurons by a postsynaptic increase of AMPAR-mediated currents. These synaptic changes, in addition to the acquisition of the task, depend on NMDAR activation. Amygdala neurons that store the memory of a reward are activated when an animal compares the expected reward with the unexpected omission of that reward. Finally, distinct populations of amygdala neurons reflect the motivating and reinforcing properties of a cue endowed with the emotional significance to guide behavior
Optogenetic investigation of projection-specific function in motivated behaviors by Kay M Tye( Visual )

1 edition published in 2013 in English and held by 1 WorldCat member library worldwide

(CIT): Motivated behaviors fall into two valences: Seeking pleasure and avoiding pain. The ability to select appropriate behavioral responses to environmental stimuli, such as avoiding a predator or approaching a food source, is critical for survival. Although most animals are capable of learning to assign either positive or negative associations to environmental cues, Dr. Tye's lab is only at the beginning to understand the underlying neural circuits and the plasticity that mediates the formation, revision or extinction of an associative memory. Dr. Tye"s lab employs an interdisciplinary approach including optogenetics, electrophysiology, pharmacology and imaging techniques to find a mechanistic explanation for how emotional and motivational states can influence learning and behavior, in both health and disease
Amygdala processing of the formation and retrieval of cue-reward associations by Kay M Tye( )

1 edition published in 2008 in English and held by 1 WorldCat member library worldwide

This thesis examines the neural changes that contribute to the formation, storage, retrieval and extinction of a learned association between a stimulus and a reward. A number of questions were answered in this thesis to provide insight upon the neural substrates of several goal-directed behaviors: What neural changes mediate the initial formation of an associative memory between a stimulus and a reward? What are the synaptic changes that correspond to the development of a change in task-relevant neuronal firing? What is the mechanism of these synaptic changes, and do they have a causal relationship? How are complex emotions such as frustration represented in the brain? How are reward-associated cues endowed with the power to guide goal-directed behaviors in the absence of primary rewards? Here I show that behavior improves with the rapid recruitment of amygdala neurons to the ensemble encoding a reward-predictive cue, and that this change is mediated by the rapid strengthening of thalamic synapses onto amygdala neurons by a postsynaptic increase of AMPAR-mediated currents. These synaptic changes, in addition to the acquisition of the task, depend on NMDAR activation. Amygdala neurons that store the memory of a reward are activated when an animal compares the expected reward with the unexpected omission of that reward. Finally, distinct populations of amygdala neurons reflect the motivating and reinforcing properties of a cue endowed with the emotional significance to guide behavior
Editorial overview: Neurobiology of behavior( )

1 edition published in 2018 in English and held by 1 WorldCat member library worldwide

 
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Audience Level
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Audience level: 0.40 (from 0.30 for Editorial ... to 0.99 for Amygdala p ...)

Alternative Names
Kay Tye Amerikaans neurowetenschapster

Kay Tye neurocientífica estadounidense

Kay Tye neurocientífica estatunidenca

Kay Tye neurocientífica estauxunidense

كاي تاي عالمة أعصاب من الولايات المتحدة الأمريكية

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