WorldCat Identities

Binder, Elisabeth (Elisabeth B.)

Overview
Works: 10 works in 27 publications in 2 languages and 476 library holdings
Roles: Editor, Author
Publication Timeline
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Most widely held works by Elisabeth Binder
Epigenetics and neuroendocrinology : clinical focus on psychiatry by Dietmar Spengler( )

15 editions published in 2016 in English and German and held by 260 WorldCat member libraries worldwide

The field of neuroendocrinology has extended from the initial interest in the hypothalamic control of pituitary secretion to embrace multiple reciprocal interactions between the central nervous system and endocrine systems in the coordination of homeostasis and various physiological responses from adaptation to disease. Most recently, epigenetic mechanisms were recognized for their role in the development of the neuroendocrine axes as well as in the mediation of gene-environment interactions in stress-related psychiatry disorders
Epigenetics and human health : clinical focus on psychiatry( )

4 editions published in 2016 in English and held by 208 WorldCat member libraries worldwide

Annotation
Molecular mechanisms of gene X environment interaction in stress-related psychiatric disorders by Elisabeth Binder( Visual )

1 edition published in 2014 in English and held by 1 WorldCat member library worldwide

(CIT): Neuroscience Seminar Series Dr. Binder has received her medical training at the Medical University of Vienna, Austria and the Universite Libre de Bruxelles, Belgium. She then completed a PhD in Neuroscience at Emory University, Atlanta, USA. She currently holds a joint appointment as as an Associate Professor in Psychiatry and Behavioral Sciences at Emory University School of Medicine and a Research Group Leader (RG Molecular Genetics of Depression) at the Max-Planck Institute of Psychiatry in Munich. Dr. Binder has authored or co-authored more than 80 original articles and book chapters in the fields of neuropsychopharmacology, neuroendocrinology and psychiatric genetics. She has received a number of awards and honors, including the Theodore Reich award of the International Society of Psychiatric Genetics and the Max Hamilton award of the Collegium Internationale Neuropsychopharmacologicum. Her main research interests are the pharmacogenetics of antidepressant drugs as well as gene x environment interactions in mood and anxiety disorders, with a focus on genes regulating the stress hormone response. The major focus of their research group is to identify the genetic bases of mood and anxiety disorders. For this they use genome-wide association studies, gene expression studies and DNA methylation studies combined with candidate gene-based approaches. These molecular data are paired with environmental information as well as a number of endophenotypes for a better understanding of the etiopathogenesis of these disorders. This might allow to identify biologically more homogenous subgroups and improve treatment options for these disorders
GENDER‐SPECIFIC ASSOCIATION OF VARIANTS IN THE AKR1C1 GENE WITH DIMENSIONAL ANXIETY IN PATIENTS WITH PANIC DISORDER: ADDITIONAL EVIDENCE FOR THE IMPORTANCE OF NEUROSTEROIDS IN ANXIETY?( )

1 edition published in 2014 in English and held by 1 WorldCat member library worldwide

Abstract Background Neurosteroids are synthesized both in brain and peripheral steroidogenic tissue from cholesterol or steroidal precursors. Neurosteroids have been shown to be implicated in neural proliferation, differentiation, and activity. Preclinical and clinical studies also suggest a modulatory role of neurosteroids in anxiety‐related phenotypes. However, little is known about the contribution of genetic variants in genes relevant for the neurosteroidogenesis to anxiety disorders. Methods We performed an association analysis of single nucleotide polymorphisms (SNPs) in five genes related to the neurosteroidal pathway with emphasis on progesterone and allopregnanolone biosynthesis (steroid‐5‐alpha‐reductase 1A (SRD5A1), aldo‐keto reductase family 1 C1‐C3 (AKR1C1‐AKR1C3) and translocator protein 18 kDA (TSPO) with panic disorder (PD) and dimensional anxiety in two German PD samples (cases N = 522, controls N = 1, 115). Results Case–control analysis for PD and SNPs in the five selected genes was negative in the combined sample. However, we detected a significant association of anticipatory anxiety with two intronic SNPs (rs3930965, rs41314625) located in the gene AKR1C1 surviving correction for multiple testing in PD patients. Stratification analysis for gender revealed a female‐specific effect of the associations of both SNPs. Conclusions These results suggest a modulatory effect of AKR1C1 activity on anxiety levels, most likely through changes in progesterone and allopregnanolone levels within and outside the brain. In summary, this is the first evidence for the gender‐specific implication of the AKR1C1 gene in the expression of anticipatory anxiety in PD. Further analyses to unravel the functional role of the SNPs detected here and replication analyses are needed to validate our results
Sequencing on the SOLiD 5500xl System - in-depth characterization of the GC bias( )

1 edition published in 2017 in English and held by 1 WorldCat member library worldwide

ABSTRACT: Different types of sequencing biases have been described and subsequently improved for a variety of sequencing systems, mostly focusing on the widely used Illumina systems. Similar studies are missing for the SOLiD 5500xl system, a sequencer which produced many data sets available to researchers today. Describing and understanding the bias is important to accurately interpret and integrate these published data in various ongoing research projects. We report a particularly strong GC bias for this sequencing system when analyzing a defined gDNA mix of 5 microbes with a wide range of different GC contents (20-72%) when comparing to the expected distribution and Illumina MiSeq data from the same DNA pool. Since we observed this bias already under PCR-free conditions, changing the PCR conditions during library preparation - a common strategy to handle bias in the Illumina system - was not relevant. Source of the bias appeared to be an uneven heat distribution during the SOLiD emulsion PCR (ePCR) - for enrichment of libraries prior loading - since ePCR in either small pouches or in 96-well plates improved the GC bias. Sequencing of chromatin immunoprecipitated DNA (ChIP-seq) is a common approach in epigenetics. ChIP-seq of the mixed source histone mark H3K9ac (acetyl Histone H3 lysine 9), typically found on promoter regions and on gene bodies, including CpG islands, performed on a SOLiD 5500xl machine, resulted in major loss of reads at GC rich loci (GC content ≥ 62%), not explained by low sequencing depth. This was improved with adaptations of the ePCR
Cohort Profile: Pregnancy And Childhood Epigenetics (PACE) Consortium( )

1 edition published in 2017 in English and held by 1 WorldCat member library worldwide

Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment( )

1 edition published in 2004 in English and held by 1 WorldCat member library worldwide

The stress hormone-regulating hypothalamic-pituitary-adrenal (HPA) axis has been implicated in the causality1 as well as the treatment of depression(2). To investigate a possible association between genes regulating the HPA axis and response to antidepressants and susceptibility for depression, we genotyped single-nucleotide polymorphisms in eight of these genes in depressed individuals and matched controls. We found significant associations of response to antidepressants and the recurrence of depressive episodes with single-nucleotide polymorphisms in FKBP5, a glucocorticoid receptor-regulating cochaperone of hsp-90, in two independent samples. These single-nucleotide polymorphisms were also associated with increased intracellular FKBP5 protein expression, which triggers adaptive changes in glucocorticoid receptor and, thereby, HPA-axis regulation. Individuals carrying the associated genotypes had less HPA-axis hyperactivity during the depressive episode. We propose that the FKBP5 variant-dependent alterations in HPA-axis regulation could be related to the faster response to antidepressant drug treatment and the increased recurrence of depressive episodes observed in this subgroup of depressed individuals. These findings support a central role of genes regulating the HPA axis in the causality of depression and the mechanism of action of antidepressant drugs
Charting the landscape of priority problems in psychiatry, part 2: pathogenesis and aetiology( )

1 edition published in 2016 in English and held by 1 WorldCat member library worldwide

This is the second of two companion papers proposing priority problems for research on mental disorders. Whereas the first paper focuses on questions of nosology and diagnosis, this Personal View concerns pathogenesis and aetiology of psychiatric diseases. We hope that this (non-exhaustive and subjective) list of problems, nominated by scientists and clinicians from different fields and institutions, provides guidance and perspectives for choosing future directions in psychiatric science
The neurobiological effects of stress as contributors to psychiatric disorders: focus on epigenetics( )

1 edition published in 2015 in English and held by 1 WorldCat member library worldwide

Highlights: Current findings on epigenetic embedding of the long term effects of stress. Describe the effects of the type and timing of stress on these mechanisms. Describe the differences in the mechanisms for tissue specific versus more global changes. Describe possible mechanisms of biological embedding of stress across generations. Abstract : A large body of evidence describes the long term impact of stress on a number of biological systems and with it associated adverse health outcomes. This article will discuss the epigenetic mechanisms of the embedding of these long term changes, the differences in these mechanisms depending on the type and timing of stress exposure, including transgenerational effects as well as differences in the mechanisms for tissue specific versus more global epigenetic changes. A mechanistic understanding of the long term epigenetic consequences of stress may allow novel, targeted intervention and prevention strategies for psychiatric and other stress-associated disorders
Charting the landscape of priority problems in psychiatry, part 1: classification and diagnosis( )

1 edition published in 2016 in English and held by 1 WorldCat member library worldwide

Contemporary psychiatry faces major challenges. Its syndrome-based disease classification is not based on mechanisms and does not guide treatment, which largely depends on trial and error. The development of therapies is hindered by ignorance of potential beneficiary patient subgroups. Neuroscientific and genetics research have yet to affect disease definitions or contribute to clinical decision making. In this challenging setting, what should psychiatric research focus on? In two companion papers, we present a list of problems nominated by clinicians and researchers from different disciplines as candidates for future scientific investigation of mental disorders. These problems are loosely grouped into challenges concerning nosology and diagnosis (this Personal View) and problems related to pathogenesis and aetiology (in the companion Personal View). Motivated by successful examples in other disciplines, particularly the list of Hilbert's problems in mathematics, this subjective and eclectic list of priority problems is intended for psychiatric researchers, helping to re-focus existing research and providing perspectives for future psychiatric science
 
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Alternative Names
Elisabeth Binder Austrian psychiatrist

Elisabeth Binder österreichische Medizinerin und Neurowissenschaftlerin

Elisabeth Binder psychiatrice uit Oostenrijk

Languages
English (26)

German (1)