WorldCat Identities

Ferreira, S. H. 1934-

Overview
Works: 38 works in 63 publications in 3 languages and 563 library holdings
Roles: Editor, Thesis advisor, Author
Classifications: QP905, 615.108 S
Publication Timeline
.
Most widely held works by S. H Ferreira
Inflammation by John R Vane( Book )

11 editions published between 1978 and 1979 in English and held by 223 WorldCat member libraries worldwide

Throughout the centuries, inflammation has been considered as a disease in itself. This misconception arose from the inability to distinguish between inflammatory changes and the insults which induce them. The understanding of the distinction between the genesis of inflammation and the tissue reactions that follow is attributed to JOHN HUNTER, who, at the end of the 18th century, substantially contributed to the analysis of inflammation in objective terms. Today, however, we are still trying to find explanations for Celsus' Signs in terms of structural and functional changes occurring in the inflamed tissue. There are drugs which modulate these signs but, without a detailed knowledge of the basic physiopathological events, it is impossible to understand their mechanism of action. Notwithstanding, the effects of anti inflammatory drugs provided new knowledge of the relevance of the signs and symptoms to the sequence of biochemical and morphological changes occurring in inflammation. When we accepted the invitation to edit a Handbook on Inflammation and Anti Inflammatory Drugs, we were aware of the magnitude of the task. We knew the impossibility of covering the whole field in detail, especially taking into account the rapid accumulation of experimental knowledge which would, in all likelihood, overtake the process of publication
Anti-inflammatory drugs by John R Vane( Book )

12 editions published between 1978 and 1979 in English and German and held by 222 WorldCat member libraries worldwide

Handbook of experimental pharmacology( Book )

2 editions published in 1979 in English and held by 2 WorldCat member libraries worldwide

Handbuch der experimentellen Pharmakologie( Book )

1 edition published in 1979 in English and held by 2 WorldCat member libraries worldwide

Participation of interleukin-5, interleukin-8 and leukotriene B4 in eosinophil accumulation in two different experimental models by Sandra H. P Oliveira( )

1 edition published in 1997 in English and held by 2 WorldCat member libraries worldwide

There are several experimental models descibing in vivo eosinophil (EO) migration, including injection of a large volume of saline (SAL) or Sephadex beads (SEP). The aim of this study was to investigate the mechanisms involved in the EO migration in these two models. Two consecutive injections of SAL given 48 hr apart, induced a selective recruitment of EO into peritoneal cavity of rats, which peaked 48 hr after the last injection. SEP, when injected, promoted EO accumulation in rats. The phenomenom was dose-related and peaked 48 hr after injection. To investigate the mediators involved in this process we showed that BW A4C, MK 886 and dexamethasone (DXA) inhibited the EO migration induced by SAL and SEP. To investigate the source of the EO chemotactic factor we showed that mast cells, macrophages (MO), but not lymphocytes, incubated in vitro in presence of SAL released a factor which induced EO migration. With SEP, only mast cells release a factor that induced EO migration, which was inhibited by BW A4C, MK 886 and DXA. Furthermore, the chemotactic activity of SAL-stimulated mast cells was inhibited by antisera against IL-5 and IL-8 (interleukin). SAL-stimulated MO were only inhibited by anti-IL-8 antibodies as well as SEP-stimulated mast cells. These results suggest that the EO migration induced by SAL may be dependent on resident mast cells and MO mediated by LTB4, IL-5 and IL-8. SEP-induced EO migration was dependent on mast cells and may be mediated by LTB4 and IL-8. Furthermore, IL-5 and IL-8 induced EO migration, which was also dependent on resident cells and mediated by LTB4. In conclusion, EO migration induced by SAL is dependent on mast cells and MO, whereas that induced by SEP is dependent on mast cells alone. Stimulated mast cells release LTB4, IL-5 and IL-8 while MO release LTB4 and IL-8. The IL-5 and and IL-8 release by the SAL or SEP-stimulated resident cells may act in an autocrine fashion, thus potentiating LTB4 release. (AU)
Inflammation( Book )

in English and held by 2 WorldCat member libraries worldwide

Handbook of experimental pharmacology( Book )

2 editions published in 1978 in English and held by 2 WorldCat member libraries worldwide

Chronic intrathecal cannulation enhances nociceptive responses in rats by F. R. C Almeida( )

1 edition published in 2000 in English and held by 2 WorldCat member libraries worldwide

The influence of a chronically implanted spinal cannula on the nociceptive response induced by mechanical, chemical or thermal stimuli was evaluated. The hyperalgesia in response to mechanical stimulation induced by carrageenin or prostaglandin E2 (PGE2) was significantly increased in cannulated (Cn) rats, compared with naive (Nv) or sham-operated (Sh) rats. Only Cn animals presented an enhanced nociceptive response in the first phase of the formalin test when low doses were used (0.3 and 1 percent). The withdrawal latency to thermal stimulation of a paw inflamed by carrageenin was significantly reduced in Cn rats but not in Nv or Sh rats. In contrast to Nv and Sh rats, injection in Cn animals of a standard non-steroid anti-inflammatory drug, indomethacin, either intraperitoneally or into the spinal cord via an implanted cannula or by direct puncture of the intrathecal space significantly blocked the intensity of the hyperalgesia induced by PGE2. Cannulated animals treated with indomethacin also showed a significant inhibition of second phase formalin-induced paw flinches. Histopathological analysis of the spinal cord showed an increased frequency of mononuclear inflammatory cells in the Cn groups. Thus, the presence of a chronically implanted cannula seems to cause nociceptive spinal sensitization to mechanical, chemical and thermal stimulation, which can be blocked by indomethacin, thus suggesting that it may result from the spinal release of prostaglandins due to an ongoing mild inflammation (AU)
Nimesulide : a multifactorial therapeutic approach to the inflammatory process? : a 7-year clinical experience : proceedings of the International Congress on Nimesulide held in Berlin, October 1-3, 1992 by International Congress on Nimesulide( Book )

3 editions published in 1993 in English and held by 2 WorldCat member libraries worldwide

Nitric oxide mediates the microbicidal activity of eosinophils by Sandra H. P Oliveira( )

1 edition published in 1997 in English and held by 2 WorldCat member libraries worldwide

There are several experimental evidences that nitric oxide (NO) is involved in the microbicidal activity of macrophages against a number of intracellular pathogens including Leishmania major, Trypanosoma cruzi, Toxoplasma gondii. It is also well known that eosinophils (EO) have microbicidal activity against many parasites such as Schistosoma mansoni, Trichenella spiralis, T. cruzi and L. amazonensis. The purpose of this study was to investigate if NO is involved in the microbicidal activity of EO against L. major. Eosinophils harvested from peritoneal cavity of rats released spontaneously after 24 and 48 hr a small amount of nitrite. This release was enhanced by the treatment of cells with IFN-gamma (200 IU/ml). This release was blocked by addition of the NO synthase inhibitor, L-NIO (100-M) into the culture. To determine the leishmanicidal activity of eosinophils the parasites were incubated with activated eosinophils with IFN-gamma and the abiblity of surviving parasites to incorporate [3H] thymidine was evaluated. IFN-gamma-activated eosinophils were able to kill L. major and to release high levels of nitrite. The ability to destroy L. major and the release of NO were completely blocked by L-NIO. These results indicate that activated eosinophils release NO which is involved in the microbicidal activity of these cells against L. major. (AU)
Brazilian Journal of Medical and Biological Research 1981-2002 by Eduardo Moacyr Krieger( )

1 edition published in 2003 in English and held by 2 WorldCat member libraries worldwide

University discoveries and intellectual property rights: from Bothrops jararaca bradykinin potentiating peptides to angiotensin converting enzyme inhibitors by S. H Ferreira( )

1 edition published in 1994 in English and held by 1 WorldCat member library worldwide

The academic basic research which led to the discovery of bradykinin potentiating peptides the drug proteotype for the new class of angiotensin converting enzyme inhibitors for the treatment of hypertension, is described. This case study is used to illustrate the situation of the academic scientist and his intellectual property rights for discoveries made at the University (AU)
The peripheral analgesic effect of morphine, codeine, pentazocine and dpropoxyphene by Nelson Molina Valencia( )

1 edition published in 1983 in English and held by 1 WorldCat member library worldwide

Do fator potenciacao da bradicinina (BPF) aos inibidores da ECA by S. H Ferreira( )

1 edition published in 1998 in Portuguese and held by 1 WorldCat member library worldwide

Interleukin- I mimics the hyperalgesia induced by a factor obtained by macrophage lysis by J. N Francischi( )

1 edition published in 1988 in English and held by 1 WorldCat member library worldwide

Medicamentos a partir de plantas medicinais no Brasil( Book )

1 edition published in 1998 in Portuguese and held by 1 WorldCat member library worldwide

Participação do neurônio aferente primário na antinocicepção de agonistas opióides administrados por via intraplantar e intratecal by Mani Indiana Funez( Book )

1 edition published in 2004 in Portuguese and held by 1 WorldCat member library worldwide

Na tentativa de dissociar efeitos analgésicos de efeitos indesejados dos opióides algumas estratégias têm sido estudadas, dentre elas síntese de agonistas específicos para os subtipos de receptores ou ainda agonistas que não sejam capazes de cruzar a barreira hematoencefálica além da administração destas drogas por vias alternativas. Neste contexto, este estudo objetivou 1) identificar o possível efeito antinociceptivo de agonistas opióides capa ('capa'), o U50488 e o ICI204448 (o qual não cruza a barreira hematoencefálica), administrados por via intraplantar (ipl) ou intratecal (it); 2) confirmar sua especificidade; 3) comparar seus efeitos com os efeitos da morfina; 4) também investigar a participação da via metabólica L -arginina/NO/GMPc nos efeitos antinociceptivos de agonistas 'capa' (ipl ou it) e da morfina (it) e 5) investigar a contribuição do neurônio aferente primário para o efeito antinociceptivo de opióides administrados it. Para a realização de nossos protocolos experimentais utilizamos um modelo de hipernocicepção mecânica induzida por 'PGE IND. 2' em patas de ratos que mimetiza hiperalgesia inflamatória em humanos. As injeções ipl ou it de morfina (0.7-6 ug) e agonistas 'capa', em doses que não afetam o comportamento locomotor dos animais (10-40 ug), induziram antinocicepção significativa. O efeito destes agonistas foi restrito ao sítio de injeção, visto que não se observou efeito antinociceptivo nas patas contralater
Quaternary ammonium salt derivatives of allylphenols with peripheral analgesic effect by A. B. de Oliveira( )

1 edition published in 1991 in English and held by 1 WorldCat member library worldwide

Ammonium salt derivatives of natural allylphenols were synthesized with the purpose of obtaining potential peripheral analgesics. These drugs, by virtue of their physicochemical properties, would not be able to cross the blood brain barrier. Their inability to enter into the central nervous system (CNS) should prevent several adverse effects observed with classical opiate analgesics (Ferreira et al., 1984). Eugenol (1) O-methyleugenol (5) and safrole (9) were submitted to nitration, reduction and permethylation, leading to the ammonium salts 4, 8 and 12. Another strategy applied to eugenol (1), consisting in its conversion to a glycidic ether (13), opening the epoxide ring with secondary amines and methylation, led to the ammonium salts 16 and 17. All these ammonium salts showed significant peripheral analgesic action, in modified version of the Randall-Sellito test (Ferreira et al. 1978), at non-lethal doses. The ammonium salt 8 showed an activity comparable to that of methylnalorphinium, the prototype of an ideal peripheral analgesic (Ferreira et al., 1984)
Macrophages stimulated with lipopolysaccharide release a selective neutrophil chemotatic factor: an in vivo demonstration by F. Q Cunha( )

1 edition published in 1986 in English and held by 1 WorldCat member library worldwide

Fatores hiperalgésicos presentes no macrófago by Janetti Nogueira de Francischi( Book )

1 edition published in 1982 in Portuguese and held by 1 WorldCat member library worldwide

 
moreShow More Titles
fewerShow Fewer Titles
Audience Level
0
Audience Level
1
  Kids General Special  
Audience level: 0.72 (from 0.71 for Inflammati ... to 1.00 for University ...)

Alternative Names
Ferreira, S. H.

Ferreira, Sérgio Henrique 1934-

Sérgio Henrique Ferreira brasilianischer Pharmakologe

Sérgio Henrique Ferreira Brazilian scientist

Sérgio Henrique Ferreira farmacoloog uit Brazilië

سرجیو هنریکه فریرا

Languages