WorldCat Identities

Laakso, Markku

Overview
Works: 48 works in 68 publications in 2 languages and 97 library holdings
Roles: Author, Other
Classifications: JN6713,
Publication Timeline
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Most widely held works by Markku Laakso
Kansanedustuslaitos koalitio- ja valtasuhderakenteena : koalitioteoreettisia tutkimuksia by Markku Laakso( Book )

7 editions published in 1975 in Finnish and Undetermined and held by 26 WorldCat member libraries worldwide

Atherosclerotic vascular disease and its risk factors in non-insulin- dependent diabetics in East Finland by Markku Laakso( Book )

3 editions published in 1986 in English and held by 6 WorldCat member libraries worldwide

Vallan jakautuminen Länsi-Euroopan parlamenteissa by Markku Laakso( Book )

2 editions published in 1980 in Finnish and held by 5 WorldCat member libraries worldwide

Vaalijärjestelmämme uudistamisvaihtoehtoja by Markku Laakso( Book )

2 editions published in 1978 in Finnish and held by 3 WorldCat member libraries worldwide

Poliittisten vastakohtaisuuksien mittaaminen by Markku Laakso( Book )

2 editions published in 1972 in Finnish and held by 3 WorldCat member libraries worldwide

Eräitä eduskunnan päätöksenteon rakenteellisia piirteitä by Markku Laakso( Book )

2 editions published in 1972 in Finnish and held by 3 WorldCat member libraries worldwide

Eduskunnan päätössääntöjärjestelmä ja vaalimenetelmä by Markku Laakso( Book )

2 editions published in 1975 in Finnish and held by 2 WorldCat member libraries worldwide

Majoitusinvestointien taloudellisista perusteista( Book )

1 edition published in 1976 in Finnish and held by 2 WorldCat member libraries worldwide

Lohjan seudun ilmanlaadun tarkkailu : yhteenveto mittaustuloksista vuosilta 1988-1995 by Markku Laakso( Book )

2 editions published in 1996 in Finnish and held by 2 WorldCat member libraries worldwide

Valtaindeksien paradoksit by Markku Laakso( Book )

2 editions published in 1978 in Finnish and held by 2 WorldCat member libraries worldwide

Vaalijärjestelmän muutos ja sen jatkovaikutukset : havaintoja 15 Länsi-Euroopan maan vaaleista ensimmäisen maailmansodan jälkeen by Markku Laakso( Book )

2 editions published in 1979 in Finnish and held by 2 WorldCat member libraries worldwide

Kansainväliset tulonjakovertailut: Metodisia ja tulkinnallisia näkökohtia by Markku Laakso( Book )

2 editions published in 1973 in Finnish and held by 2 WorldCat member libraries worldwide

Feasibility study of existing low-pressure water hydraulic components( Book )

2 editions published in 1999 in English and held by 2 WorldCat member libraries worldwide

Vaalien suhteellisuus Länsi-Euroopan maissa toisen maailmansodan jälkeen by Markku Laakso( Book )

1 edition published in 1978 in Finnish and held by 1 WorldCat member library worldwide

Rikkidioksidipäästöt by Markku Laakso( Book )

1 edition published in 1980 in Finnish and held by 1 WorldCat member library worldwide

New Blood Pressure–Associated Loci Identified in Meta-Analyses of 475 000 Individuals( )

1 edition published in 2017 in English and held by 1 WorldCat member library worldwide

Abstract : Background—: Genome-wide association studies have recently identified >400 loci that harbor DNA sequence variants that influence blood pressure (BP). Our earlier studies identified and validated 56 single nucleotide variants (SNVs) associated with BP from meta-analyses of exome chip genotype data. An additional 100 variants yielded suggestive evidence of association. Methods and Results—: Here, we augment the sample with 140 886 European individuals from the UK Biobank, in whom 77 of the 100 suggestive SNVs were available for association analysis with systolic BP or diastolic BP or pulse pressure. We performed 2 meta-analyses, one in individuals of European, South Asian, African, and Hispanic descent (pan-ancestry, ≈475 000), and the other in the subset of individuals of European descent (≈423 000). Twenty-one SNVs were genome-wide significant ( P <5×10 −8 ) for BP, of which 4 are new BP loci: rs9678851 (missense, SLC4A1AP ), rs7437940 ( AFAP1 ), rs13303 (missense, STAB1 ), and rs1055144 ( 7p15.2 ). In addition, we identified a potentially independent novel BP-associated SNV, rs3416322 (missense, SYNPO2L ) at a known locus, uncorrelated with the previously reported SNVs. Two SNVs are associated with expression levels of nearby genes, and SNVs at 3 loci are associated with other traits. One SNV with a minor allele frequency <0.01, (rs3025380 at DBH ) was genome-wide significant. Conclusions—: We report 4 novel loci associated with BP regulation, and 1 independent variant at an established BP locus. This analysis highlights several candidate genes with variation that alter protein function or gene expression for potential follow-up. Abstract : Supplemental Digital Content is available in the text
Äänet, paikat ja päätösvalta : vaalijärjestelmämme uudistusvaihtoehtojen jatkoanalyysiä by Markku Laakso( Book )

1 edition published in 1980 in Finnish and held by 1 WorldCat member library worldwide

Ukontie jatkosodassa vuosina 1941-1945 by Markku Laakso( )

1 edition published in 1978 in Finnish and held by 1 WorldCat member library worldwide

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture by Sonja I Berndt( )

1 edition published in 2013 in English and held by 1 WorldCat member library worldwide

Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups
 
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Alternative Names
Markku Laakso dokter asal Finlandia

Markku Laakso Fins universitair docent (1949-)

Languages