WorldCat Identities

McCulloch, Ernest A. 1926-2011

Overview
Works: 18 works in 45 publications in 1 language and 2,129 library holdings
Genres: Conference papers and proceedings  History  Abstracts 
Roles: Author, Editor, Honoree
Publication Timeline
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Most widely held works about Ernest A McCulloch
 
Most widely held works by Ernest A McCulloch
The Ontario Cancer Institute : successes and reverses at Sherbourne Street by Ernest A McCulloch( )

11 editions published between 2003 and 2014 in English and held by 1,456 WorldCat member libraries worldwide

In The Ontario Cancer Institute Ernest McCulloch discusses how the institute, dedicated to the goal of reducing the burden of cancer, continuously strove for excellence and shows how both original and collaborative work were encouraged within a supportive environment
Cellular and molecular biology of hemopoietic stem cell differentiation : proceedings of a symposium held at Honey Harbor, Ontario, Canada, September 20-24, 1981 by Tak W Mak( Book )

11 editions published in 1982 in English and held by 251 WorldCat member libraries worldwide

Selected abstracts on the stem cell origin of neoplasia by Ernest A McCulloch( Book )

3 editions published in 1984 in English and held by 54 WorldCat member libraries worldwide

New approaches to the treatment of leukemia by A. M Marmont( )

1 edition published in 1990 in English and held by 49 WorldCat member libraries worldwide

This book is the product of a task force which met to exchange ideas and stimulate discussion about new approaches to the treatment of leukaemia. Five major areas of innovation are examined in papers generated by professionals who are well known in their respective fields. Current results in chemotherapy, immunotherapy, biological response modifiers, bone marrow transplantation and cytogenetics, and molecular genetics are presented. These new approaches in the treatment of leukaemia will undoubtedly find prompt application to the treatment of other malignancies
Cell culture techniques( Book )

3 editions published in 1984 in English and held by 49 WorldCat member libraries worldwide

Cellular and molecular biology of hemopoietic stem cell differentiation( Book )

2 editions published in 1982 in English and held by 5 WorldCat member libraries worldwide

Special issue in honor of Dr. E.A. McCulloch on the occasion of his 65th birthday( Book )

2 editions published in 1991 in English and held by 4 WorldCat member libraries worldwide

Repair processes 'n irradiated mouse hematopoietic uissue( Book )

1 edition published in 1944 in English and held by 1 WorldCat member library worldwide

It is the purpose of this paper to describe experiments in which the colony-forming ability of these cells was measured at intervals following irradiation. The initial adiationinduced loss of proliferative capacity in uhese cells is repaired with time, and this repair is considered to be of two types. Early repair occurs in the first 24 hours after irradiation, and is qrobably the result of recovery processes occuring within sublethally damaged cells, similar to those described by Elkind for mammalian cells in culture. Late repair occurs after 24 hours and is probably the result of cellular proliferation. Measurement of both types of repair processes involved exposing mice to two doses of radiation, separated by an interval of time. By comparing the results obtained in these experiments with the kinetics of repair of colony-forming cells, it is possible to determine whether or not colonyforming cells form an important part of the cellular systems necessary for survival. (Author)
Proliferation of hemopoietic colony-forming cells transplanted into irradiated mice( Book )

1 edition published in 1963 in English and held by 1 WorldCat member library worldwide

The kinetics of proliferation of spleen colonyforming cells derived from transplanted marrow cells have been studied by means of two different methods. The results of thest experiments indicate that transplanted colony-forming cells do not proliferate in heavily irradiated receipients during the first day after transplantation, but that after this initial lag phase they increase in number in an exponential fashion for at least the next 7 days, with a doubling time of 20 to 25 hours. A transient increase in the Do of the survival curve for transplanted colony-forming cells derived from marrow was observed during the posttransplantation lag phase. This increase was maximal approximately 1 day after transplantation. (Author)
The effect of differing demands for blood cell production on dna synthesis of hemopoietic colony-forming cells of mice( Book )

1 edition published in 1964 in English and held by 1 WorldCat member library worldwide

A technic capable of estimating the fraction of hemopoietic colony-forming progenitor cells in DNA synthesis in vivo has been described. The technic is based on the ability of tritiated thymidine to inhibit the growth of those colony-forming cells which, by virtue of their presence in the S-phase during a 20-minute incubation in vitro, in the presence of 500 microcuries/ ml. of H3TdR, have incorporated large amounts of the nucleoside. The method has been applied to transplanted colony-forming cells proliferating in spleens of heavily irradiated recipients as well as to cells from normal fetal liver, normal marrow, and normal spleen. In situations where the hemopoietic system is expanding (fetal liver and regenerating transplants), a large fraction, 40-65 per cent, of the stem cells are in DNA synthesis. In the steady-state situations (adult marrow and spleen), the fraction of cells in DNA synthesis is almost imperceptible using this technic. It is concluded that control mechanisms which govern the rate of hemopoiesis operate, at least in part, by altering the generative cycle of bloodforming progenitor cells. (Author)
The sensitivity of cells from normal mouse bone marrow to gamma radiation in vitro and in vivo( Book )

1 edition published in 1961 in English and held by 1 WorldCat member library worldwide

Normal mouse bone marrow contains a small population of cells with the capacity to give rise to macroscopic colonies containing differential hemic cells in the spleens of heavily irradiated animals. A radiation survival curve for these colony-forming cells after irradiation in vitro has been published (1). However, it remained to be shown whether this survival curve is applicable to colony-forming cells irradiated under physiological conditions in the animal. In the present paper, a survival curve for the colonyforming cells irradiated in vivo is presented and compared with the in vitro survival curve. Although these two curves are very similar, a significant difference does exist between them. (Author)
REPRESSION OF COLONY-FORMING ABILITY OF C57BL HEMATOPOIETIC CELLS TRANSPLANTED INTO NONISOLOGOUS HOSTS( Book )

1 edition published in 1963 in English and held by 1 WorldCat member library worldwide

The present experiments have shown that a suspension of cells derived from C57BL mice consistently yields a lower value for the CFU content when tested in irradiated (C57BL X C3H)F1 recipients than when tested in irradiated isologous recipients, though the ability of the transplanted cells to enhance survival of the irradiated mice remains similar in both cases. This effect is termed CFU repression. The results of experiments designed to delineate this phenomenon do not permit us to make a ready identification of CFU repression with any of the well-established phenomena of tissue transplantation. Though the mechanism of CFU repression remains obscure, its elucidation may provide valuable information about the factors influencing the development of spleen colonies
Radiation responses of hemopoietic colonyforming cells derived from different sources( Book )

1 edition published in 1964 in English and held by 1 WorldCat member library worldwide

Hemopoietic colony-forming cells derived from adult femoral marrow, adult spleen, and fetal liver did not exhibit a uniform sensitivity to radiation when freshly explanted cells from these sources were tested in the same way for the survival of colony-forming ability after irradiation in vivo. The D sub 0 values and extrapolation numbers observed were: for adult femoral marrow, 95 = 9 rads, 1.50 = 0.54; for adult spleen, 90 = 16 rads, 0.80 = 0.46; for fetal liver, 146 = 26 rads, 1.08 = 0.50. Fourteen days after transplantation into X-irradiated (900 rads) hosts, hemopoietic colony-forming cells derived from femoral marrow, spleen, or fetal liver showed a relatively uniform, increased radiation sensitivity for cells proliferating in spleen or in marrow. The D sub 0 values and extrapolation numbers for cells proliferating in spleen were found to be: for cells derived originally from marrow, 69 = 12 rads, 0.99 = 0.42 for cells derived from spleen, 74 = 15 rads, 0.77 = 0.43; for cells derived from fetal liver, 80 = 16 rads, 0.72 = 0.42. For cells derived from fetal liver, the increase in radiation response took place during the first 6 days after transplantation of the cells into irradiated hosts. (Author)
Decline in colony-forming ability of marrow cells subjected to serial transplantation into irradiated mice( Book )

1 edition published in 1964 in English and held by 1 WorldCat member library worldwide

It is concluded that colony-forming cells derived from normal marrow are not capable of indefinite proliferation when they are subjected to the pressure of repeated transplantation. Cells with colony-forming ability found within spleen colonies cannot be considered to be exact replications of their original colony-forming ancestors since they have reduced capacity for selfrenewal. This view is supported by the results of preliminary experiments designed to compare the radiation sensitivities of colony-forming cells before and after transplantation. It was found that the radiation sensitivity of colony-forming ability increases in cells subjected to serial transplantation, which again suggests that the self-renewal process does not necessarily result in an exact replication of the original colony-forming cells
A DIRECT MEASUREMENT OF THE RADIATION SENSITIVITY OF NORMAL MOUSE BONE MARROW CELLS( Book )

1 edition published in 1960 in English and held by 1 WorldCat member library worldwide

A direct technique for the measurement of the number of cells in a bone marrow suspension capable of continued proliferation is described. The technique was used to measure the radiation sensitivity of normal mouse bone marrow cells and yielded a Do of 115 plus or minus 8 rads
The Ontario Cancer Institute successes and reverses at Sherbourne Street by Ernest A McCulloch( )

1 edition published in 2003 in English and held by 0 WorldCat member libraries worldwide

 
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The Ontario Cancer Institute : successes and reverses at Sherbourne Street
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Alternative Names
Ernest McCulloch Canadees arts (1926-2011)

Ernest McCulloch cellular biologist

Ernest McCulloch kanadischer Hämatologe

McCulloch, E.A. 1926-

McCulloch, E. A. 1926-2011

McCulloch, E.A. (Ernest A.), 1926-

McCulloch, E. A. (Ernest A.), 1926-2011

McCulloch, Ernest Armstrong 1926-2011

अर्नस्ट.ए.मुकलॉक

アーネスト・マコラック

恩尼斯特·莫科洛克

Languages
English (45)