Lands, William E. M. 1930-
Overview
| Works: | 22 works in 88 publications in 1 language and 1,898 library holdings |
|---|---|
| Genres: | Conference papers and proceedings |
| Roles: | Author, Editor, Other |
| Classifications: | QP601, 612.405 |
Publication Timeline
.
Most widely held works by
William E. M Lands
Prostaglandins and arachidonate metabolites(
Book
)
11 editions published in 1982 in English and held by 431 WorldCat member libraries worldwide
The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences
11 editions published in 1982 in English and held by 431 WorldCat member libraries worldwide
The critically acclaimed laboratory standard, Methods in Enzymology, is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. The series contains much material still relevant today - truly an essential publication for researchers in all fields of life sciences
Fish and human health by
William E. M Lands(
Book
)
12 editions published between 1986 and 1996 in English and held by 398 WorldCat member libraries worldwide
12 editions published between 1986 and 1996 in English and held by 398 WorldCat member libraries worldwide
Prostaglandins and Cyclic AMP : biological action and clinical applications by
William E. M Lands(
Book
)
13 editions published between 1973 and 1975 in English and held by 311 WorldCat member libraries worldwide
13 editions published between 1973 and 1975 in English and held by 311 WorldCat member libraries worldwide
Biochemistry of arachidonic acid metabolism by
Kenneth V Honn(
Book
)
11 editions published in 1985 in English and held by 186 WorldCat member libraries worldwide
11 editions published in 1985 in English and held by 186 WorldCat member libraries worldwide
Proceedings of the AOCS Short Course on Polyunsaturated Fatty Acids and Eicosanoids by
AOCS Short Course on Polyunsaturated Fatty Acids and Eicosanoids(
Book
)
10 editions published in 1987 in English and held by 117 WorldCat member libraries worldwide
10 editions published in 1987 in English and held by 117 WorldCat member libraries worldwide
Fish, Omega 3 and human health by
William E. M Lands(
Book
)
9 editions published in 2005 in English and held by 78 WorldCat member libraries worldwide
9 editions published in 2005 in English and held by 78 WorldCat member libraries worldwide
Focus on omega-3(
)
1 edition published in 2008 in English and held by 10 WorldCat member libraries worldwide
This CD-ROM combines talks from AOCS annual meetings with abstracts and articles from three AOCS journals, Lipids, JAOCS and Inform plus several AOCS books. Several illustrated, narrated presentations from the 2007 AOCS meeting give authoritative overviews to help interpret the abstracts and selected publications
1 edition published in 2008 in English and held by 10 WorldCat member libraries worldwide
This CD-ROM combines talks from AOCS annual meetings with abstracts and articles from three AOCS journals, Lipids, JAOCS and Inform plus several AOCS books. Several illustrated, narrated presentations from the 2007 AOCS meeting give authoritative overviews to help interpret the abstracts and selected publications
Methods in enzymology by
William E. M Lands(
Book
)
5 editions published in 1982 in English and held by 5 WorldCat member libraries worldwide
5 editions published in 1982 in English and held by 5 WorldCat member libraries worldwide
The carbohydrate containing lipids of corn by
William E. M Lands(
Book
)
3 editions published in 1954 in English and held by 4 WorldCat member libraries worldwide
3 editions published in 1954 in English and held by 4 WorldCat member libraries worldwide
Prevention of coronary heart disease : from the cholesterol hypothesis to [omega]6/ [omega]3 balance by
Harumi Okuyama(
Book
)
1 edition published in 2007 in English and held by 1 WorldCat member library worldwide
1 edition published in 2007 in English and held by 1 WorldCat member library worldwide
Methods in enzymology(
Book
)
1 edition published in 2005 in English and held by 1 WorldCat member library worldwide
1 edition published in 2005 in English and held by 1 WorldCat member library worldwide
Biochemical preparations by
William E. M Lands(
Book
)
1 edition published in 1968 in English and held by 1 WorldCat member library worldwide
1 edition published in 1968 in English and held by 1 WorldCat member library worldwide
Possible beneficial effects of polyunsaturated fatty acids in maritime foods by
William E. M Lands(
Book
)
1 edition published in 1983 in English and held by 1 WorldCat member library worldwide
1 edition published in 1983 in English and held by 1 WorldCat member library worldwide
Prostaglandins and arachiclorak metabolites(
Book
)
1 edition published in 1982 in English and held by 1 WorldCat member library worldwide
1 edition published in 1982 in English and held by 1 WorldCat member library worldwide
Hydroperoxide stimulation of prostaglandin endoperoxide synthase by Robert Brian Pendleton(
)
1 edition published in 1990 in English and held by 1 WorldCat member library worldwide
Hydroperoxide is required to activate prostaglandin endoperoxide synthase (PES) cyclooxygenase by formation of an enzyme-radical species (derived from a PES peroxidase intermediate), and is generated by the cyclooxygenase reaction, thereby causing a positive feedback in the rate of oxygenation (hydroperoxide amplification). A kinetic model that integrates the cyclooxygenase and peroxidase activities was proposed. Numerical integration of the kinetic rate equations was found to accurately predict both the time-course of oxygen consumption, and the levels of prostaglandin G$sb2$ (PGG$sb2$) hydroperoxide, during oxygenation of arachidonic acid (20:4n-6). 15-Hydroperoxyeicosatetraenoic acid (15-HPETE), was found to be a highly effective activator of the cyclooxygenase activity using a kinetic assay based upon the ability of hydroperoxide to overcome the antagonistic effects of sodium cyanide. Phospholipid triglyceride, and cholesterol ester hydroperoxides were ineffective, but became highly effective after enzymatic hydrolysis, and therefore, PES requires an non-esterified hydroperoxide for activation. The mono-hydroperoxy positional isomers of oxidized arachidonate had decreasing effectiveness as the hydroperoxide group was located nearer to the acid terminus, and the cyclic endoperoxy-hydroperoxides PGG$sb2$ and PGG$sb3$ had only one sixth the activity of 15-HPETE. Unexpectedly, the oxygenation of 20:5n-3 was found to be more responsive to 15-HPETE activator than the oxygenation of 20:4n-6. Using sodium cyanide or glutathione peroxidase as hydroperoxide antagonists the hydroperoxide amplification process was found to be impaired in the reaction with eicosapentaenoate (20:5n-3). The rate constant for the initial reaction between enzyme and hydroperoxide was found to be equal for both PGG$sb2$ and PGG$sb3$ and therefore the impaired reactivity of 20:5n-3 probably did not involve the steps leading to the radical-enzyme intermediate. Using OXYSIM, a computer program for numerically integrating the proposed kinetic equations and a systematic process for adjusting the kinetic constants, it was found that the impaired hydroperoxide amplification of the 20:5n-3 reaction could be accounted for by a 4.6-fold decreased rate of oxygen insertion, and a 2.2-fold increased rate of cyclooxygenase inactivation. These data provide a greater understanding of hydroperoxide and prostaglandin metabolism, and a mechanistic rational for the therapeutic effects of dietary 20:5n-3 in certain inflammatory and thromboembolic diseases where prostaglandin overproduction is believed to be pathologic
1 edition published in 1990 in English and held by 1 WorldCat member library worldwide
Hydroperoxide is required to activate prostaglandin endoperoxide synthase (PES) cyclooxygenase by formation of an enzyme-radical species (derived from a PES peroxidase intermediate), and is generated by the cyclooxygenase reaction, thereby causing a positive feedback in the rate of oxygenation (hydroperoxide amplification). A kinetic model that integrates the cyclooxygenase and peroxidase activities was proposed. Numerical integration of the kinetic rate equations was found to accurately predict both the time-course of oxygen consumption, and the levels of prostaglandin G$sb2$ (PGG$sb2$) hydroperoxide, during oxygenation of arachidonic acid (20:4n-6). 15-Hydroperoxyeicosatetraenoic acid (15-HPETE), was found to be a highly effective activator of the cyclooxygenase activity using a kinetic assay based upon the ability of hydroperoxide to overcome the antagonistic effects of sodium cyanide. Phospholipid triglyceride, and cholesterol ester hydroperoxides were ineffective, but became highly effective after enzymatic hydrolysis, and therefore, PES requires an non-esterified hydroperoxide for activation. The mono-hydroperoxy positional isomers of oxidized arachidonate had decreasing effectiveness as the hydroperoxide group was located nearer to the acid terminus, and the cyclic endoperoxy-hydroperoxides PGG$sb2$ and PGG$sb3$ had only one sixth the activity of 15-HPETE. Unexpectedly, the oxygenation of 20:5n-3 was found to be more responsive to 15-HPETE activator than the oxygenation of 20:4n-6. Using sodium cyanide or glutathione peroxidase as hydroperoxide antagonists the hydroperoxide amplification process was found to be impaired in the reaction with eicosapentaenoate (20:5n-3). The rate constant for the initial reaction between enzyme and hydroperoxide was found to be equal for both PGG$sb2$ and PGG$sb3$ and therefore the impaired reactivity of 20:5n-3 probably did not involve the steps leading to the radical-enzyme intermediate. Using OXYSIM, a computer program for numerically integrating the proposed kinetic equations and a systematic process for adjusting the kinetic constants, it was found that the impaired hydroperoxide amplification of the 20:5n-3 reaction could be accounted for by a 4.6-fold decreased rate of oxygen insertion, and a 2.2-fold increased rate of cyclooxygenase inactivation. These data provide a greater understanding of hydroperoxide and prostaglandin metabolism, and a mechanistic rational for the therapeutic effects of dietary 20:5n-3 in certain inflammatory and thromboembolic diseases where prostaglandin overproduction is believed to be pathologic
The Carbohydrate Containing Lipids of Corn by
William E. M Lands(
)
1 edition published in 1954 in English and held by 1 WorldCat member library worldwide
1 edition published in 1954 in English and held by 1 WorldCat member library worldwide
Biochemical preparations by
John H Law(
Book
)
in English and held by 1 WorldCat member library worldwide
in English and held by 1 WorldCat member library worldwide
Prevention of Coronary Heart Disease. World Review of Nutrition and Dietetics, Volume 96(
)
1 edition published in 2007 in English and held by 0 WorldCat member libraries worldwide
This publication is organized in an exceptional way: Each chapter introduces several completed clinical trials and provides the original conclusions and discussions of the results. The authors then contribute their own comments and interpretations of the findings, challenging the prevailing belief that serum cholesterol is a mediator of disease which is increased by eating saturated fats and decreased by eating polyunsaturated fats. They argue that upon closer scrutiny, the diet recommendations based on the cholesterol hypothesis are essentially ineffective in reducing serum cholesterol levels in the long run. Instead, it is proposed that traditional cholesterol biomarkers are of different significance in short- and long-term interventions due to the feedback control mechanisms in the body. Even more important, the association of high serum cholesterol values with high coronary heart disease mortality is not consistent when different populations are compared: This mortality rate may simply reflect the incidence and severity of familial hypercholesterolemia cases. This agrees with the observation that higher serum cholesterol values associate with lower cancer and all-cause mortalities in populations with a low relative proportion of this disorder. Thus, there seems to be no benefit of limiting dietary cholesterol intake or lowering serum cholesterol values below a certain limit. Moreover, evidence has been found that the health risk results from high intakes of calories, aggravated by an unbalanced intake of omega6/omega3 polyunsaturated fats. Based on the reviewed data, new directions of lipid nutrition are recommended for the primary and secondary prevention of coronary heart disease, cancer and all-cause deaths, which will likely revolutionize current dietary practice
1 edition published in 2007 in English and held by 0 WorldCat member libraries worldwide
This publication is organized in an exceptional way: Each chapter introduces several completed clinical trials and provides the original conclusions and discussions of the results. The authors then contribute their own comments and interpretations of the findings, challenging the prevailing belief that serum cholesterol is a mediator of disease which is increased by eating saturated fats and decreased by eating polyunsaturated fats. They argue that upon closer scrutiny, the diet recommendations based on the cholesterol hypothesis are essentially ineffective in reducing serum cholesterol levels in the long run. Instead, it is proposed that traditional cholesterol biomarkers are of different significance in short- and long-term interventions due to the feedback control mechanisms in the body. Even more important, the association of high serum cholesterol values with high coronary heart disease mortality is not consistent when different populations are compared: This mortality rate may simply reflect the incidence and severity of familial hypercholesterolemia cases. This agrees with the observation that higher serum cholesterol values associate with lower cancer and all-cause mortalities in populations with a low relative proportion of this disorder. Thus, there seems to be no benefit of limiting dietary cholesterol intake or lowering serum cholesterol values below a certain limit. Moreover, evidence has been found that the health risk results from high intakes of calories, aggravated by an unbalanced intake of omega6/omega3 polyunsaturated fats. Based on the reviewed data, new directions of lipid nutrition are recommended for the primary and secondary prevention of coronary heart disease, cancer and all-cause deaths, which will likely revolutionize current dietary practice
Biochemistry of Arachidonic Acid Metabolism by
William E. M Lands(
)
1 edition published in 1985 in English and held by 0 WorldCat member libraries worldwide
Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car cinoma. Since that time, the concept that arachidonic acid metabolites may be in volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from arachidonic acid) via the cyclooxygenase and lipoxygenase pathways, respec tively. Cyclooxygenase products consist of diverse products such as prosta glandin E, (POE,), prostacyclin (POI2) and thromboxane A2 (TXA2), whereas lipoxygenase products consist of hydroperoxy fatty acids and mono-, di- and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lip oxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate. This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengt Samuelsson's extensive study of the metabolism of pros taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autocoids
1 edition published in 1985 in English and held by 0 WorldCat member libraries worldwide
Prostaglandins, Leukotrienes, and Cancer is a multi-volume series that will focus on an emerging area of cancer research. In 1968, R.H. Williams first reported that elevated prostaglandin levels are present in human medullary car cinoma. Since that time, the concept that arachidonic acid metabolites may be in volved in cancer has expanded to include every aspect of the disease from cell transformation through metastasis. Prostaglandins and leukotrienes are generic terms used to describe a family of bioactive lipids produced from unsaturated fatty acids (principally from arachidonic acid) via the cyclooxygenase and lipoxygenase pathways, respec tively. Cyclooxygenase products consist of diverse products such as prosta glandin E, (POE,), prostacyclin (POI2) and thromboxane A2 (TXA2), whereas lipoxygenase products consist of hydroperoxy fatty acids and mono-, di- and tri-hydroxy acids including leukotrienes. The precursor fatty acids for the cyclooxygenase and lip oxygenase pathways are present in cellular phospholipids. This finding established an important control point in their biosynthesis-the release of substrate. This occurs in response to numerous stimuli that act at the cell surface. Dr. Bengt Samuelsson's extensive study of the metabolism of pros taglandins indicated that they are rapidly inactivated on a single pass through pulmonary circulation. Thus, they cannot act as circulating hormones and appear to be made on demand in or in the vicinity of target tissues leading to the concept that prostaglandins are local hormones or autocoids
more
fewer
Audience Level
| 0 |
 |
1 | ||
| Kids | General | Special | ||
Related Identities
- Smith, William L. (Professor of biological chemistry) Editor
- Kahn, Raymond H. 1930- Editor
- American Oil Chemists' Society Other
- Marnett, Lawrence J.
- Honn, Kenneth V. Author
- Symposium on the Medical Aspects of Prostaglandins and Cyclic Amp(1972 Universi
- Smith, William L. Editor
- Symposium on the Medical Aspects of Prostaglandins and Cyclic AMP 1972 Ann Arbor, Mich
- Sun, Y.
- Ichikawa, Y.
Useful Links
Associated Subjects
Arachidonic acid Arachidonic acid--Metabolism Biochemistry Cancer cells Cell transformation Coronary heart disease Coronary heart disease--Nutritional aspects Coronary heart disease--Prevention Cyclic adenylic acid Diet Eicosanoic acid--Derivatives--Therapeutic use Eicosanoids--Physiological effect Essential fatty acids in human nutrition Fatty acids Fish as food Fishes Heart--Diseases--Nutritional aspects Heart--Diseases--Prevention Hypercholesteremia Lipids Medicine Nutritionally induced diseases Omega-3 fatty acids Omega-6/omega-3 fatty acid ratio Oncology Prostaglandins Tumors Unsaturated fatty acids in human nutrition Unsaturated fatty acids--Physiological effect Unsaturated fatty acids--Therapeutic use
Alternative Names
Lands, W. E. M.
Lands, W. E. M. 1930-
Lands, W. E. M. (William E. M.), 1930-
Lands, W. E. M. (William Edward Mitchell), 1930-
Lands, William E. M.
William E.M. Lands American scientist
Languages
Covers
![Prevention of coronary heart disease : from the cholesterol hypothesis to [omega]6/ [omega]3 balance](http://coverart.oclc.org/ImageWebSvc/isbn/+-+5426300538324_140.jpg?SearchOrder=+-+GO)