WorldCat Identities

Andersson, Leif C.

Works: 10 works in 33 publications in 3 languages and 289 library holdings
Genres: Conference papers and proceedings 
Roles: Author, Editor, Other
Publication Timeline
Most widely held works by Leif C Andersson
Gene expression during normal and malignant differentiation by Sigrid Jusélius Foundation( Book )

11 editions published in 1985 in English and held by 189 WorldCat member libraries worldwide

Origin of major histocompatibility complex diversity( Book )

4 editions published in 1995 in English and held by 58 WorldCat member libraries worldwide

Konsumentintresset : en språkspelsorienterad studie by Leif C Andersson( Book )

7 editions published in 1982 in Swedish and Undetermined and held by 26 WorldCat member libraries worldwide

Cytotoxic lymphocytes in allograft response by Leif C Andersson( Book )

5 editions published in 1973 in English and Swedish and held by 10 WorldCat member libraries worldwide

Differentiated Paju cells have increased resistance to toxic effects of potassium ionophores( )

1 edition published in 2004 in English and held by 1 WorldCat member library worldwide

Materiały z 29th Congress of the Federation of European Biochemical Societies, Warszawa
Salivary MMP‐13 gender differences in periodontitis: A cross‐sectional study from Sweden( )

1 edition published in 2017 in English and held by 1 WorldCat member library worldwide

Abstract: We investigated serum and saliva concentrations of matrix metalloproteinases, MMP‐8, MMP‐9, and MMP‐13, and their tissue inhibitor TIMP‐1, in a group of patients with and without periodontitis from Sweden. The hypothesis was that these biomarkers are higher in the periodontitis patients. Ninety patients participated in this cross‐sectional study. Fifty‐one patients had periodontitis whereas 39 were periodontally healthy. Saliva and serum samples were analyzed with immunofluorometric, enzyme‐linked immunosorbent assay and western blot. Results were statistically analyzed with independent t test, Mann–Whitney U test, Bonferroni corrections, and regression analyses. MMP‐13 was not detected in serum, but in saliva, higher values were found among the periodontally healthy compared with periodontitis subjects (0.32±0.26 vs. 0.21±0.23ng/ml, p <.05). Female gender and clinical attachment loss were the explanatory factors for higher salivary MMP‐13 values with odds ratio 3.08 (95% confidence interval [1.17, 8.11]) and 3.57 (95% confidence interval [1.08, 11.82]), respectively. No statistically significant differences between groups were found in serum and saliva values of MMP‐8, MMP‐9, and TIMP‐1. Contrary to our hypothesis, no statistically significant differences between patients with and without periodontitis were seen in MMP‐8, MMP‐9, and TIMP‐1 values. However, higher MMP‐13 concentrations in saliva were associated with female gender and higher clinical attachment loss. Metabolism of MMP‐13 may thus have some gender implications in periodontitis
Latex-virtsatiekatetrien kudostoksisuus( Book )

1 edition published in 1988 in Finnish and held by 1 WorldCat member library worldwide

Fatal Puumala Hantavirus Disease Involvement of Complement Activation and Vascular Leakage in the Pathobiology by Tarja Sironen( )

1 edition published in 2017 in English and held by 1 WorldCat member library worldwide

The case-fatality rate of hantavirus disease depends strongly on the causative hantavirus, ranging from 0.1% to 40%. However, the pathogenesis is not fully understood, and at present no licensed therapies exist. We describe fatal cases caused by Puumala hantavirus indicating involvement of complement activation and vascular leakage
Prognostic and diagnostic value of REG4 serum and tissue expression in pancreatic ductal adenocarcinoma( )

1 edition published in 2018 in English and held by 1 WorldCat member library worldwide

Expression of regenerating islet-derived protein 4 (REG4), a secretory protein involved in cell differentiation and proliferation, is upregulated in inflammatory bowel diseases and in many gastrointestinal malignancies. The prognostic significance of its expression in pancreatic ductal adenocarcinoma is unknown. Our aim was to investigate tumor tissue and serum REG4 expression in pancreatic ductal adenocarcinoma patients. We also evaluated as a control the diagnostic value of serum REG4 level in patients with chronic pancreatitis. Immunohistochemical expression of REG4 was evaluated in 154 surgical specimens and serum REG4 level in 130 samples from pancreatic ductal adenocarcinoma patients treated at Helsinki University Hospital, Finland, in 2000–2011. REG4 tissue and serum expression was assessed in relation to clinicopathological parameters and patient survival. A chronic pancreatitis control group comprised 34 patients who underwent pancreatic resection because of suspicion of malignancy. Significant survival differences were detectable in subgroups: in tumor stages IA–IIA, high serum REG4 level predicted worse survival (p=0.046). In patients with grade I tumor, positive tissue REG4 expression predicted better survival (p=0.006). In multivariate analysis, neither tissue nor serum REG4 expression was independent prognostic factors. Serum REG4 levels were higher in pancreatic ductal adenocarcinoma than in chronic pancreatitis (p=0.002), with diagnostic sensitivity of 45% and specificity of 91%. In logistic regression analysis, a multivariate model with REG4, CA19-9, and age provided sensitivity of 82% and specificity of 79%. REG4 tissue expression is a prognostic marker in subgroups of pancreatic ductal adenocarcinoma patients. Serum REG4 level might be useful in differential diagnosis between pancreatic ductal adenocarcinoma and chronic pancreatitis
Establishment of a spontaneously transformed cell line (JU-PI) from a myxoinflammatory fibroblastic sarcoma( )

1 edition published in 2018 in English and held by 1 WorldCat member library worldwide

Myxoinflammatory fibroblastic sarcoma is a soft-tissue neoplasm most frequently found in the distal extremities of middle-aged adults. Most myxoinflammatory fibroblastic sarcoma are low-grade tumors with propensity for local recurrence after incomplete removal. We report a myxoinflammatory fibroblastic sarcoma which developed in the foot of a 41-year-old male and showed an exceptionally aggressive course with metastatic spread and fatal outcome within 16 months. We managed to establish a spontaneously transformed continuous cell line, called JU-PI, from a metastatic lesion. The JU-PI cells have a sub-tetraploid karyotype including the 1;10 chromosomal translocation and amplification of the proximal end of 3p; these features are considered genetic signatures of myxoinflammatory fibroblastic sarcoma. Both the primary tumor and the JU-PI cells showed nuclear expression of the TFE3 transcription factor but TFE3-activating chromosomal rearrangements were not found. To our knowledge, JU-PI is the first established myxoinflammatory fibroblastic sarcoma cell line. JU-PI cells offer a tool for investigating the molecular oncology of myxoinflammatory fibroblastic sarcoma
Audience Level
Audience Level
  Kids General Special  
Audience level: 0.71 (from 0.67 for Gene expre ... to 0.99 for Latex-virt ...)

Alternative Names
Andersson, L.

Andersson, L. (Leif C.)

Leif Andersson Finnish physician and professor of pathology (emeritus; University of Helsinki & Karoliska Institutet), director of pathology and genetics (Hospital District of Helsinki and Uusimaa)

Leif Andersson Fins arts

Лейф Андерссон